WRN Gene

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Tang, P. WRN Gene. Encyclopedia. Available online: https://encyclopedia.pub/entry/4625 (accessed on 28 September 2026).

Tang P. WRN Gene. Encyclopedia. Available at: https://encyclopedia.pub/entry/4625. Accessed September 28, 2026.

Tang, Peter. "WRN Gene" Encyclopedia, https://encyclopedia.pub/entry/4625 (accessed September 28, 2026).

Tang, P. (2020, December 24). WRN Gene. In Encyclopedia. https://encyclopedia.pub/entry/4625

Tang, Peter. "WRN Gene." Encyclopedia. Web. 24 December, 2020.

WRN Gene

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This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/gene/wrn

Werner syndrome RecQ like helicase: the WRN gene provides instructions for producing the Werner protein, which plays a critical role in repairing damaged DNA. The Werner protein functions as a type of enzyme called a helicase.

genes

References

Agrelo R, Cheng WH, Setien F, Ropero S, Espada J, Fraga MF, Herranz M, Paz MF,Sanchez-Cespedes M, Artiga MJ, Guerrero D, Castells A, von Kobbe C, Bohr VA,Esteller M. Epigenetic inactivation of the premature aging Werner syndrome genein human cancer. Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8822-7.
Cheng WH, Muftuoglu M, Bohr VA. Werner syndrome protein: functions in theresponse to DNA damage and replication stress in S-phase. Exp Gerontol. 2007Sep;42(9):871-8.
Comai L, Li B. The Werner syndrome protein at the crossroads of DNA repair andapoptosis. Mech Ageing Dev. 2004 Aug;125(8):521-8. Review.
Futami K, Ishikawa Y, Goto M, Furuichi Y, Sugimoto M. Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancercells. Cancer Sci. 2008 May;99(5):843-8. doi: 10.1111/j.1349-7006.2008.00778.x.
Huang S, Lee L, Hanson NB, Lenaerts C, Hoehn H, Poot M, Rubin CD, Chen DF,Yang CC, Juch H, Dorn T, Spiegel R, Oral EA, Abid M, Battisti C, Lucci-CordiscoE, Neri G, Steed EH, Kidd A, Isley W, Showalter D, Vittone JL, Konstantinow A,Ring J, Meyer P, Wenger SL, von Herbay A, Wollina U, Schuelke M, Huizenga CR,Leistritz DF, Martin GM, Mian IS, Oshima J. The spectrum of WRN mutations inWerner syndrome patients. Hum Mutat. 2006 Jun;27(6):558-67.
Kudlow BA, Kennedy BK, Monnat RJ Jr. Werner and Hutchinson-Gilford progeriasyndromes: mechanistic basis of human progeroid diseases. Nat Rev Mol Cell Biol. 2007 May;8(5):394-404. Review.
Lee JW, Harrigan J, Opresko PL, Bohr VA. Pathways and functions of the Werner syndrome protein. Mech Ageing Dev. 2005 Jan;126(1):79-86. Review.
Monnat RJ Jr, Saintigny Y. Werner syndrome protein--unwinding function toexplain disease. Sci Aging Knowledge Environ. 2004 Mar 31;2004(13):re3. Review.
Opresko PL, Calvo JP, von Kobbe C. Role for the Werner syndrome protein in thepromotion of tumor cell growth. Mech Ageing Dev. 2007 Jul-Aug;128(7-8):423-36.
Oshima J, Martin GM, Hisama FM. Werner Syndrome. 2002 Dec 2 [updated 2016 Sep 29]. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K,Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University ofWashington, Seattle; 1993-2020. Available fromhttp://www.ncbi.nlm.nih.gov/books/NBK1514/
Ozgenc A, Loeb LA. Current advances in unraveling the function of the Wernersyndrome protein. Mutat Res. 2005 Sep 4;577(1-2):237-51. Review.

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Subjects: Genetics & Heredity

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