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Xu, C. Lymphedema-Distichiasis Syndrome. Encyclopedia. Available online: https://encyclopedia.pub/entry/4561 (accessed on 27 September 2026).
Xu C. Lymphedema-Distichiasis Syndrome. Encyclopedia. Available at: https://encyclopedia.pub/entry/4561. Accessed September 27, 2026.
Xu, Camila. "Lymphedema-Distichiasis Syndrome" Encyclopedia, https://encyclopedia.pub/entry/4561 (accessed September 27, 2026).
Xu, C. (2020, December 24). Lymphedema-Distichiasis Syndrome. In Encyclopedia. https://encyclopedia.pub/entry/4561
Xu, Camila. "Lymphedema-Distichiasis Syndrome." Encyclopedia. Web. 24 December, 2020.
Lymphedema-Distichiasis Syndrome
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This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/lymphedema-distichiasis-syndrome

Lymphedema-distichiasis syndrome is a condition that affects the normal function of the lymphatic system, which is a part of the circulatory and immune systems. The lymphatic system produces and transports fluids and immune cells throughout the body.

genetic conditions

References

  1. Brice G, Mansour S, Bell R, Collin JR, Child AH, Brady AF, Sarfarazi M,Burnand KG, Jeffery S, Mortimer P, Murday VA. Analysis of the phenotypicabnormalities in lymphoedema-distichiasis syndrome in 74 patients with FOXC2mutations or linkage to 16q24. J Med Genet. 2002 Jul;39(7):478-83.
  2. Erickson RP, Dagenais SL, Caulder MS, Downs CA, Herman G, Jones MC,Kerstjens-Frederikse WS, Lidral AC, McDonald M, Nelson CC, Witte M, Glover TW.Clinical heterogeneity in lymphoedema-distichiasis with FOXC2 truncatingmutations. J Med Genet. 2001 Nov;38(11):761-6.
  3. Fang J, Dagenais SL, Erickson RP, Arlt MF, Glynn MW, Gorski JL, Seaver LH,Glover TW. Mutations in FOXC2 (MFH-1), a forkhead family transcription factor,are responsible for the hereditary lymphedema-distichiasis syndrome. Am J HumGenet. 2000 Dec;67(6):1382-8.
  4. Mellor RH, Brice G, Stanton AW, French J, Smith A, Jeffery S, Levick JR,Burnand KG, Mortimer PS; Lymphoedema Research Consortium. Mutations in FOXC2 are strongly associated with primary valve failure in veins of the lower limb.Circulation. 2007 Apr 10;115(14):1912-20.
  5. Sutkowska E, Bator A, Trompeta K, Szuba A. Different lymphscintigraphicpatterns in patients with lymphedema distichiasis. Lymphology. 2010Jun;43(2):73-7.
  6. Vreeburg M, Heitink MV, Damstra RJ, Moog U, van Geel M, van Steensel MA.Lymphedema-distichiasis syndrome: a distinct type of primary lymphedema caused bymutations in the FOXC2 gene. Int J Dermatol. 2008 Nov;47 Suppl 1:52-5. doi:10.1111/j.1365-4632.2008.03962.x.
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Subjects: Genetics & Heredity
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Camila Xu
View Times: 851
Entry Collection: MedlinePlus
Revision: 1 time (View History)
Update Date: 24 Dec 2020
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