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Xu, C. Lacrimo-Auriculo-Dento-Digital Syndrome. Encyclopedia. Available online: https://encyclopedia.pub/entry/4437 (accessed on 27 September 2026).
Xu C. Lacrimo-Auriculo-Dento-Digital Syndrome. Encyclopedia. Available at: https://encyclopedia.pub/entry/4437. Accessed September 27, 2026.
Xu, Camila. "Lacrimo-Auriculo-Dento-Digital Syndrome" Encyclopedia, https://encyclopedia.pub/entry/4437 (accessed September 27, 2026).
Xu, C. (2020, December 23). Lacrimo-Auriculo-Dento-Digital Syndrome. In Encyclopedia. https://encyclopedia.pub/entry/4437
Xu, Camila. "Lacrimo-Auriculo-Dento-Digital Syndrome." Encyclopedia. Web. 23 December, 2020.
Lacrimo-Auriculo-Dento-Digital Syndrome
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This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/lacrimo-auriculo-dento-digital-syndrome

Lacrimo-auriculo-dento-digital (LADD) syndrome is a genetic disorder that mainly affects the eyes, ears, mouth, and hands. LADD syndrome is characterized by defects in the tear-producing lacrimal system (lacrimo-), ear problems (auriculo-), dental abnormalities (dento-), and deformities of the fingers (digital).

genetic conditions

References

  1. Guven Y, Rosti RO, Tuna EB, Kayserili H, Aktoren O. Orodental findings of afamily with lacrimo-auriculo-dento digital (LADD) syndrome. Oral Surg Oral MedOral Pathol Oral Radiol Endod. 2008 Dec;106(6):e33-44. doi:10.1016/j.tripleo.2008.07.019.
  2. Inan UU, Yilmaz MD, Demir Y, Degirmenci B, Ermis SS, Ozturk F. Characteristicsof lacrimo-auriculo-dento-digital (LADD) syndrome: case report of a family andliterature review. Int J Pediatr Otorhinolaryngol. 2006 Jul;70(7):1307-14.
  3. Lew ED, Bae JH, Rohmann E, Wollnik B, Schlessinger J. Structural basis forreduced FGFR2 activity in LADD syndrome: Implications for FGFR autoinhibition andactivation. Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19802-7.
  4. Lim LT, Blum R, Chia SN, Ting DS, Lavy TE, Dutton GN.Lacrimal-auricular-dental-digital (LADD) syndrome with diffuse ophthalmoplegia--anew finding. Semin Ophthalmol. 2012 May-Jul;27(3-4):59-60. doi:10.3109/08820538.2012.680639.
  5. Milunsky JM, Zhao G, Maher TA, Colby R, Everman DB. LADD syndrome is caused byFGF10 mutations. Clin Genet. 2006 Apr;69(4):349-54.
  6. Ramirez D, Lammer EJ. Lacrimoauriculodentodigital syndrome with cleftlip/palate and renal manifestations. Cleft Palate Craniofac J. 2004Sep;41(5):501-6.
  7. Rohmann E, Brunner HG, Kayserili H, Uyguner O, Nürnberg G, Lew ED, Dobbie A,Eswarakumar VP, Uzumcu A, Ulubil-Emeroglu M, Leroy JG, Li Y, Becker C, LehnerdtK, Cremers CW, Yüksel-Apak M, Nürnberg P, Kubisch C, Schlessinger J, van BokhovenH, Wollnik B. Mutations in different components of FGF signaling in LADDsyndrome. Nat Genet. 2006 Apr;38(4):414-7.Genet. 2006 Apr;38(4):495. Kubisch, Chriütian [corrected to Kubisch, Christian].
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Subjects: Genetics & Heredity
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Camila Xu
View Times: 860
Entry Collection: MedlinePlus
Revision: 1 time (View History)
Update Date: 23 Dec 2020
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