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Liu, D. LGI1 Gene. Encyclopedia. Available online: https://encyclopedia.pub/entry/4400 (accessed on 29 September 2026).
Liu D. LGI1 Gene. Encyclopedia. Available at: https://encyclopedia.pub/entry/4400. Accessed September 29, 2026.
Liu, Dean. "LGI1 Gene" Encyclopedia, https://encyclopedia.pub/entry/4400 (accessed September 29, 2026).
Liu, D. (2020, December 23). LGI1 Gene. In Encyclopedia. https://encyclopedia.pub/entry/4400
Liu, Dean. "LGI1 Gene." Encyclopedia. Web. 23 December, 2020.
LGI1 Gene
Edit

Leucine rich glioma inactivated 1

genes

References

  1. Chernova OB, Somerville RP, Cowell JK. A novel gene, LGI1, from 10q24 isrearranged and downregulated in malignant brain tumors. Oncogene. 1998 Dec3;17(22):2873-81.
  2. Fukata Y, Adesnik H, Iwanaga T, Bredt DS, Nicoll RA, Fukata M.Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptictransmission. Science. 2006 Sep 22;313(5794):1792-5.
  3. Furlan S, Roncaroli F, Forner F, Vitiello L, Calabria E, Piquer-Sirerol S,Valle G, Perez-Tur J, Michelucci R, Nobile C. The LGI1/epitempin gene encodes twoprotein isoforms differentially expressed in human brain. J Neurochem. 2006Aug;98(3):985-91.
  4. Gu W, Brodtkorb E, Piepoli T, Finocchiaro G, Steinlein OK. LGI1: a geneinvolved in epileptogenesis and glioma progression? Neurogenetics. 2005May;6(2):59-66.
  5. Gu W, Brodtkorb E, Steinlein OK. LGI1 is mutated in familial temporal lobeepilepsy characterized by aphasic seizures. Ann Neurol. 2002 Sep;52(3):364-7.
  6. Kalachikov S, Evgrafov O, Ross B, Winawer M, Barker-Cummings C, MartinelliBoneschi F, Choi C, Morozov P, Das K, Teplitskaya E, Yu A, Cayanis E,Penchaszadeh G, Kottmann AH, Pedley TA, Hauser WA, Ottman R, Gilliam TC.Mutations in LGI1 cause autosomal-dominant partial epilepsy with auditoryfeatures. Nat Genet. 2002 Mar;30(3):335-41.
  7. Morante-Redolat JM, Gorostidi-Pagola A, Piquer-Sirerol S, Sáenz A, Poza JJ,Galán J, Gesk S, Sarafidou T, Mautner VF, Binelli S, Staub E, Hinzmann B, French L, Prud'homme JF, Passarelli D, Scannapieco P, Tassinari CA, Avanzini G,Martí-Massó JF, Kluwe L, Deloukas P, Moschonas NK, Michelucci R, Siebert R,Nobile C, Pérez-Tur J, López de Munain A. Mutations in the LGI1/Epitempin gene on10q24 cause autosomal dominant lateral temporal epilepsy. Hum Mol Genet. 2002 May1;11(9):1119-28.
  8. Ottman R, Winawer MR, Kalachikov S, Barker-Cummings C, Gilliam TC, Pedley TA, Hauser WA. LGI1 mutations in autosomal dominant partial epilepsy with auditoryfeatures. Neurology. 2004 Apr 13;62(7):1120-6.
  9. Piepoli T, Jakupoglu C, Gu W, Lualdi E, Suarez-Merino B, Poliani PL, Cattaneo MG, Ortino B, Goplen D, Wang J, Mola R, Inverardi F, Frassoni C, Bjerkvig R,Steinlein O, Vicentini LM, Brüstle O, Finocchiaro G. Expression studies ingliomas and glial cells do not support a tumor suppressor role for LGI1. NeuroOncol. 2006 Apr;8(2):96-108.
  10. Schulte U, Thumfart JO, Klöcker N, Sailer CA, Bildl W, Biniossek M, Dehn D,Deller T, Eble S, Abbass K, Wangler T, Knaus HG, Fakler B. The epilepsy-linkedLgi1 protein assembles into presynaptic Kv1 channels and inhibits inactivation byKvbeta1. Neuron. 2006 Mar 2;49(5):697-706.
  11. Senechal KR, Thaller C, Noebels JL. ADPEAF mutations reduce levels of secretedLGI1, a putative tumor suppressor protein linked to epilepsy. Hum Mol Genet. 2005Jun 15;14(12):1613-20.
  12. Sirerol-Piquer MS, Ayerdi-Izquierdo A, Morante-Redolat JM, Herranz-Pérez V,Favell K, Barker PA, Pérez-Tur J. The epilepsy gene LGI1 encodes a secretedglycoprotein that binds to the cell surface. Hum Mol Genet. 2006 Dec1;15(23):3436-45.
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