MyD88 Deficiency

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Xu, R. MyD88 Deficiency. Encyclopedia. Available online: https://encyclopedia.pub/entry/4395 (accessed on 27 September 2026).

Xu R. MyD88 Deficiency. Encyclopedia. Available at: https://encyclopedia.pub/entry/4395. Accessed September 27, 2026.

Xu, Rita. "MyD88 Deficiency" Encyclopedia, https://encyclopedia.pub/entry/4395 (accessed September 27, 2026).

Xu, R. (2020, December 23). MyD88 Deficiency. In Encyclopedia. https://encyclopedia.pub/entry/4395

Xu, Rita. "MyD88 Deficiency." Encyclopedia. Web. 23 December, 2020.

MyD88 Deficiency

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This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/myd88-deficiency

MyD88 deficiency is an inherited disorder of the immune system (primary immunodeficiency).

genetic conditions

References

Maglione PJ, Simchoni N, Black S, Radigan L, Overbey JR, Bagiella E, BusselJB, Bossuyt X, Casanova JL, Meyts I, Cerutti A, Picard C, Cunningham-Rundles C.IRAK-4 and MyD88 deficiencies impair IgM responses against T-independentbacterial antigens. Blood. 2014 Dec 4;124(24):3561-71. doi:10.1182/blood-2014-07-587824.
Picard C, Casanova JL, Puel A. Infectious diseases in patients with IRAK-4,MyD88, NEMO, or IκBα deficiency. Clin Microbiol Rev. 2011 Jul;24(3):490-7. doi:10.1128/CMR.00001-11. Review.
Picard C, von Bernuth H, Ghandil P, Chrabieh M, Levy O, Arkwright PD, McDonaldD, Geha RS, Takada H, Krause JC, Creech CB, Ku CL, Ehl S, Maródi L, Al-Muhsen S, Al-Hajjar S, Al-Ghonaium A, Day-Good NK, Holland SM, Gallin JI, Chapel H, Speert DP, Rodriguez-Gallego C, Colino E, Garty BZ, Roifman C, Hara T, Yoshikawa H,Nonoyama S, Domachowske J, Issekutz AC, Tang M, Smart J, Zitnik SE, Hoarau C,Kumararatne DS, Thrasher AJ, Davies EG, Bethune C, Sirvent N, de Ricaud D,Camcioglu Y, Vasconcelos J, Guedes M, Vitor AB, Rodrigo C, Almazán F, Méndez M,Aróstegui JI, Alsina L, Fortuny C, Reichenbach J, Verbsky JW, Bossuyt X,Doffinger R, Abel L, Puel A, Casanova JL. Clinical features and outcome ofpatients with IRAK-4 and MyD88 deficiency. Medicine (Baltimore). 2010Nov;89(6):403-25. doi: 10.1097/MD.0b013e3181fd8ec3.
von Bernuth H, Picard C, Jin Z, Pankla R, Xiao H, Ku CL, Chrabieh M, Mustapha IB, Ghandil P, Camcioglu Y, Vasconcelos J, Sirvent N, Guedes M, Vitor AB,Herrero-Mata MJ, Aróstegui JI, Rodrigo C, Alsina L, Ruiz-Ortiz E, Juan M, FortunyC, Yagüe J, Antón J, Pascal M, Chang HH, Janniere L, Rose Y, Garty BZ, Chapel H, Issekutz A, Maródi L, Rodriguez-Gallego C, Banchereau J, Abel L, Li X, ChaussabelD, Puel A, Casanova JL. Pyogenic bacterial infections in humans with MyD88deficiency. Science. 2008 Aug 1;321(5889):691-6. doi: 10.1126/science.1158298.
von Bernuth H, Picard C, Puel A, Casanova JL. Experimental and naturalinfections in MyD88- and IRAK-4-deficient mice and humans. Eur J Immunol. 2012Dec;42(12):3126-35. doi: 10.1002/eji.201242683. Review.
Yamamoto T, Tsutsumi N, Tochio H, Ohnishi H, Kubota K, Kato Z, Shirakawa M,Kondo N. Functional assessment of the mutational effects of human IRAK4 and MyD88genes. Mol Immunol. 2014 Mar;58(1):66-76. doi: 10.1016/j.molimm.2013.11.008.

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Subjects: Genetics & Heredity

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Update Date: 23 Dec 2020

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