Multiple System Atrophy

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Xu, R. Multiple System Atrophy. Encyclopedia. Available online: https://encyclopedia.pub/entry/4387 (accessed on 28 September 2026).

Xu R. Multiple System Atrophy. Encyclopedia. Available at: https://encyclopedia.pub/entry/4387. Accessed September 28, 2026.

Xu, Rita. "Multiple System Atrophy" Encyclopedia, https://encyclopedia.pub/entry/4387 (accessed September 28, 2026).

Xu, R. (2020, December 23). Multiple System Atrophy. In Encyclopedia. https://encyclopedia.pub/entry/4387

Xu, Rita. "Multiple System Atrophy." Encyclopedia. Web. 23 December, 2020.

Multiple System Atrophy

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This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/multiple-system-atrophy

Multiple system atrophy is a progressive brain disorder that affects movement and balance and disrupts the function of the autonomic nervous system. The autonomic nervous system controls body functions that are mostly involuntary, such as regulation of blood pressure. The most frequent autonomic symptoms associated with multiple system atrophy are a sudden drop in blood pressure upon standing (orthostatic hypotension), urinary difficulties, and erectile dysfunction in men.

genetic conditions

References

Al-Chalabi A, Dürr A, Wood NW, Parkinson MH, Camuzat A, Hulot JS, Morrison KE,Renton A, Sussmuth SD, Landwehrmeyer BG, Ludolph A, Agid Y, Brice A, Leigh PN,Bensimon G; NNIPPS Genetic Study Group. Genetic variants of the alpha-synucleingene SNCA are associated with multiple system atrophy. PLoS One. 2009 Sep22;4(9):e7114. doi: 10.1371/journal.pone.0007114.
Fanciulli A, Wenning GK. Multiple-system atrophy. N Engl J Med. 2015 Jan15;372(3):249-63. doi: 10.1056/NEJMra1311488. Review.
Federoff M, Schottlaender LV, Houlden H, Singleton A. Multiple system atrophy:the application of genetics in understanding etiology. Clin Auton Res. 2015Feb;25(1):19-36. doi: 10.1007/s10286-014-0267-5.
Gilman S, Wenning GK, Low PA, Brooks DJ, Mathias CJ, Trojanowski JQ, Wood NW, Colosimo C, Dürr A, Fowler CJ, Kaufmann H, Klockgether T, Lees A, Poewe W, Quinn N, Revesz T, Robertson D, Sandroni P, Seppi K, Vidailhet M. Second consensusstatement on the diagnosis of multiple system atrophy. Neurology. 2008 Aug26;71(9):670-6. doi: 10.1212/01.wnl.0000324625.00404.15.
Low PA, Reich SG, Jankovic J, Shults CW, Stern MB, Novak P, Tanner CM, Gilman S, Marshall FJ, Wooten F, Racette B, Chelimsky T, Singer W, Sletten DM, Sandroni P, Mandrekar J. Natural history of multiple system atrophy in the USA: aprospective cohort study. Lancet Neurol. 2015 Jul;14(7):710-9. doi:10.1016/S1474-4422(15)00058-7.
Multiple-System Atrophy Research Collaboration. Mutations in COQ2 in familial and sporadic multiple-system atrophy. N Engl J Med. 2013 Jul 18;369(3):233-44.doi: 10.1056/NEJMoa1212115.3;371(1):94.
Scholz SW, Houlden H, Schulte C, Sharma M, Li A, Berg D, Melchers A, Paudel R,Gibbs JR, Simon-Sanchez J, Paisan-Ruiz C, Bras J, Ding J, Chen H, Traynor BJ,Arepalli S, Zonozi RR, Revesz T, Holton J, Wood N, Lees A, Oertel W, Wüllner U,Goldwurm S, Pellecchia MT, Illig T, Riess O, Fernandez HH, Rodriguez RL, Okun MS,Poewe W, Wenning GK, Hardy JA, Singleton AB, Del Sorbo F, Schneider S, Bhatia KP,Gasser T. SNCA variants are associated with increased risk for multiple systematrophy. Ann Neurol. 2009 May;65(5):610-4. doi: 10.1002/ana.21685. Erratum in:Ann Neurol. 2010 Feb;67(2):277. Del Sorbo, Francesca [added]; Schneider, Susanne [added]; Bhatia, Kailash P [added].
Stemberger S, Scholz SW, Singleton AB, Wenning GK. Genetic players in multiplesystem atrophy: unfolding the nature of the beast. Neurobiol Aging. 2011Oct;32(10):1924.e5-14. doi: 10.1016/j.neurobiolaging.2011.04.001.

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Subjects: Genetics & Heredity

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