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Xu, R. Microvillus Inclusion Disease. Encyclopedia. Available online: https://encyclopedia.pub/entry/4180 (accessed on 29 September 2026).
Xu R. Microvillus Inclusion Disease. Encyclopedia. Available at: https://encyclopedia.pub/entry/4180. Accessed September 29, 2026.
Xu, Rita. "Microvillus Inclusion Disease" Encyclopedia, https://encyclopedia.pub/entry/4180 (accessed September 29, 2026).
Xu, R. (2020, December 23). Microvillus Inclusion Disease. In Encyclopedia. https://encyclopedia.pub/entry/4180
Xu, Rita. "Microvillus Inclusion Disease." Encyclopedia. Web. 23 December, 2020.
Microvillus Inclusion Disease
Edit

Microvillus inclusion disease is a condition characterized by chronic, watery, life-threatening diarrhea typically beginning in the first hours to days of life. Rarely, the diarrhea starts around age 3 or 4 months. Food intake increases the frequency of diarrhea.

genetic conditions

References

  1. Al-Daraji WI, Zelger B, Zelger B, Hussein MR. Microvillous inclusion disease: a clinicopathologic study of 17 cases from the UK. Ultrastruct Pathol. 2010Dec;34(6):327-32. doi: 10.3109/01913123.2010.500447.
  2. Girard M, Lacaille F, Verkarre V, Mategot R, Feldmann G, Grodet A, Sauvat F,Irtan S, Davit-Spraul A, Jacquemin E, Ruemmele F, Rainteau D, Goulet O, Colomb V,Chardot C, Henrion-Caude A, Debray D. MYO5B and bile salt export pump contribute to cholestatic liver disorder in microvillous inclusion disease. Hepatology. 2014Jul;60(1):301-10. doi: 10.1002/hep.26974.
  3. Halac U, Lacaille F, Joly F, Hugot JP, Talbotec C, Colomb V, Ruemmele FM,Goulet O. Microvillous inclusion disease: how to improve the prognosis of asevere congenital enterocyte disorder. J Pediatr Gastroenterol Nutr. 2011Apr;52(4):460-5. doi: 10.1097/MPG.0b013e3181fb4559.
  4. Khubchandani SR, Vohra P, Chitale AR, Sidana P. Microvillous inclusiondisease--an ultrastructural diagnosis: with a review of the literature.Ultrastruct Pathol. 2011 Apr;35(2):87-91. doi: 10.3109/01913123.2010.537438.Review.
  5. Knowles BC, Roland JT, Krishnan M, Tyska MJ, Lapierre LA, Dickman PS,Goldenring JR, Shub MD. Myosin Vb uncoupling from RAB8A and RAB11A elicitsmicrovillus inclusion disease. J Clin Invest. 2014 Jul;124(7):2947-62. doi:10.1172/JCI71651.
  6. Müller T, Hess MW, Schiefermeier N, Pfaller K, Ebner HL, Heinz-Erian P,Ponstingl H, Partsch J, Röllinghoff B, Köhler H, Berger T, Lenhartz H, SchlenckB, Houwen RJ, Taylor CJ, Zoller H, Lechner S, Goulet O, Utermann G, Ruemmele FM, Huber LA, Janecke AR. MYO5B mutations cause microvillus inclusion disease anddisrupt epithelial cell polarity. Nat Genet. 2008 Oct;40(10):1163-5. doi:10.1038/ng.225.
  7. Ruemmele FM, Müller T, Schiefermeier N, Ebner HL, Lechner S, Pfaller K, Thöni CE, Goulet O, Lacaille F, Schmitz J, Colomb V, Sauvat F, Revillon Y, Canioni D,Brousse N, de Saint-Basile G, Lefebvre J, Heinz-Erian P, Enninger A, Utermann G, Hess MW, Janecke AR, Huber LA. Loss-of-function of MYO5B is the main cause ofmicrovillus inclusion disease: 15 novel mutations and a CaCo-2 RNAi cell model.Hum Mutat. 2010 May;31(5):544-51. doi: 10.1002/humu.21224.
  8. Thoeni CE, Vogel GF, Tancevski I, Geley S, Lechner S, Pfaller K, Hess MW,Müller T, Janecke AR, Avitzur Y, Muise A, Cutz E, Huber LA. Microvillus inclusiondisease: loss of Myosin vb disrupts intracellular traffic and cell polarity.Traffic. 2014 Jan;15(1):22-42. doi: 10.1111/tra.12131.
  9. Wiegerinck CL, Janecke AR, Schneeberger K, Vogel GF, van Haaften-Visser DY,Escher JC, Adam R, Thöni CE, Pfaller K, Jordan AJ, Weis CA, Nijman IJ, Monroe GR,van Hasselt PM, Cutz E, Klumperman J, Clevers H, Nieuwenhuis EE, Houwen RH, vanHaaften G, Hess MW, Huber LA, Stapelbroek JM, Müller T, Middendorp S. Loss ofsyntaxin 3 causes variant microvillus inclusion disease. Gastroenterology. 2014Jul;147(1):65-68.e10. doi: 10.1053/j.gastro.2014.04.002.
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