Video Upload Options

References

1. Amary MF, Bacsi K, Maggiani F, Damato S, Halai D, Berisha F, Pollock R,O'Donnell P, Grigoriadis A, Diss T, Eskandarpour M, Presneau N, Hogendoorn PC,Futreal A, Tirabosco R, Flanagan AM. IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours. J Pathol. 2011 Jul;224(3):334-43. doi: 10.1002/path.2913.
2. Amary MF, Damato S, Halai D, Eskandarpour M, Berisha F, Bonar F, McCarthy S,Fantin VR, Straley KS, Lobo S, Aston W, Green CL, Gale RE, Tirabosco R, FutrealA, Campbell P, Presneau N, Flanagan AM. Ollier disease and Maffucci syndrome are caused by somatic mosaic mutations of IDH1 and IDH2. Nat Genet. 2011 Nov6;43(12):1262-5. doi: 10.1038/ng.994.
3. Losman JA, Looper RE, Koivunen P, Lee S, Schneider RK, McMahon C, Cowley GS,Root DE, Ebert BL, Kaelin WG Jr. (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science. 2013 Mar29;339(6127):1621-5. doi: 10.1126/science.1231677.
4. Pansuriya TC, van Eijk R, d'Adamo P, van Ruler MA, Kuijjer ML, Oosting J,Cleton-Jansen AM, van Oosterwijk JG, Verbeke SL, Meijer D, van Wezel T, Nord KH, Sangiorgi L, Toker B, Liegl-Atzwanger B, San-Julian M, Sciot R, Limaye N,Kindblom LG, Daugaard S, Godfraind C, Boon LM, Vikkula M, Kurek KC, Szuhai K,French PJ, Bovée JV. Somatic mosaic IDH1 and IDH2 mutations are associated withenchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome. Nat Genet. 2011 Nov 6;43(12):1256-61. doi: 10.1038/ng.1004.
5. Reitman ZJ, Yan H. Isocitrate dehydrogenase 1 and 2 mutations in cancer:alterations at a crossroads of cellular metabolism. J Natl Cancer Inst. 2010 Jul 7;102(13):932-41. doi: 10.1093/jnci/djq187.
6. Ward PS, Patel J, Wise DR, Abdel-Wahab O, Bennett BD, Coller HA, Cross JR,Fantin VR, Hedvat CV, Perl AE, Rabinowitz JD, Carroll M, Su SM, Sharp KA, Levine RL, Thompson CB. The common feature of leukemia-associated IDH1 and IDH2mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to2-hydroxyglutarate. Cancer Cell. 2010 Mar 16;17(3):225-34. doi:10.1016/j.ccr.2010.01.020.
7. Yan H, Parsons DW, Jin G, McLendon R, Rasheed BA, Yuan W, Kos I,Batinic-Haberle I, Jones S, Riggins GJ, Friedman H, Friedman A, Reardon D,Herndon J, Kinzler KW, Velculescu VE, Vogelstein B, Bigner DD. IDH1 and IDH2mutations in gliomas. N Engl J Med. 2009 Feb 19;360(8):765-73. doi:10.1056/NEJMoa0808710.