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Xu, C. Hereditary Diffuse Gastric Cancer. Encyclopedia. Available online: https://encyclopedia.pub/entry/4086 (accessed on 29 September 2026).
Xu C. Hereditary Diffuse Gastric Cancer. Encyclopedia. Available at: https://encyclopedia.pub/entry/4086. Accessed September 29, 2026.
Xu, Camila. "Hereditary Diffuse Gastric Cancer" Encyclopedia, https://encyclopedia.pub/entry/4086 (accessed September 29, 2026).
Xu, C. (2020, December 23). Hereditary Diffuse Gastric Cancer. In Encyclopedia. https://encyclopedia.pub/entry/4086
Xu, Camila. "Hereditary Diffuse Gastric Cancer." Encyclopedia. Web. 23 December, 2020.
Hereditary Diffuse Gastric Cancer
Edit

Hereditary diffuse gastric cancer (HDGC) is an inherited disorder that greatly increases the chance of developing a form of stomach(gastric) cancer.

genetic conditions

References

  1. Carneiro P, Fernandes MS, Figueiredo J, Caldeira J, Carvalho J, Pinheiro H,Leite M, Melo S, Oliveira P, Simões-Correia J, Oliveira MJ, Carneiro F,Figueiredo C, Paredes J, Oliveira C, Seruca R. E-cadherin dysfunction in gastric cancer--cellular consequences, clinical applications and open questions. FEBSLett. 2012 Aug 31;586(18):2981-9. doi: 10.1016/j.febslet.2012.07.045.
  2. Figueiredo J, Söderberg O, Simões-Correia J, Grannas K, Suriano G, Seruca R.The importance of E-cadherin binding partners to evaluate the pathogenicity ofE-cadherin missense mutations associated to HDGC. Eur J Hum Genet. 2013Mar;21(3):301-9. doi: 10.1038/ejhg.2012.159.
  3. Fitzgerald RC, Hardwick R, Huntsman D, Carneiro F, Guilford P, Blair V, Chung DC, Norton J, Ragunath K, Van Krieken JH, Dwerryhouse S, Caldas C; International Gastric Cancer Linkage Consortium. Hereditary diffuse gastric cancer: updatedconsensus guidelines for clinical management and directions for future research. J Med Genet. 2010 Jul;47(7):436-44. doi: 10.1136/jmg.2009.074237. Erratum in: JMed Genet. 2011 Mar;48(3):216. Van Krieken, Nicola [corrected to Van Grieken,Nicola C].
  4. Hansford S, Kaurah P, Li-Chang H, Woo M, Senz J, Pinheiro H, Schrader KA,Schaeffer DF, Shumansky K, Zogopoulos G, Santos TA, Claro I, Carvalho J, Nielsen C, Padilla S, Lum A, Talhouk A, Baker-Lange K, Richardson S, Lewis I, Lindor NM, Pennell E, MacMillan A, Fernandez B, Keller G, Lynch H, Shah SP, Guilford P,Gallinger S, Corso G, Roviello F, Caldas C, Oliveira C, Pharoah PD, Huntsman DG. Hereditary Diffuse Gastric Cancer Syndrome: CDH1 Mutations and Beyond. JAMAOncol. 2015 Apr;1(1):23-32. doi: 10.1001/jamaoncol.2014.168. Erratum in: JAMAOncol. 2015 Apr;1(1):110.
  5. Kluijt I, Siemerink EJ, Ausems MG, van Os TA, de Jong D, Simões-Correia J, vanKrieken JH, Ligtenberg MJ, Figueiredo J, van Riel E, Sijmons RH, Plukker JT, van Hillegersberg R, Dekker E, Oliveira C, Cats A, Hoogerbrugge N; Dutch WorkingGroup on Hereditary Gastric Cancer. CDH1-related hereditary diffuse gastriccancer syndrome: clinical variations and implications for counseling. Int JCancer. 2012 Jul 15;131(2):367-76. doi: 10.1002/ijc.26398.
  6. Kluijt I, Sijmons RH, Hoogerbrugge N, Plukker JT, de Jong D, van Krieken JH,van Hillegersberg R, Ligtenberg M, Bleiker E, Cats A; Dutch Working Group onHereditary Gastric Cancer. Familial gastric cancer: guidelines for diagnosis,treatment and periodic surveillance. Fam Cancer. 2012 Sep;11(3):363-9. doi:10.1007/s10689-012-9521-y.
  7. Majewski IJ, Kluijt I, Cats A, Scerri TS, de Jong D, Kluin RJ, Hansford S,Hogervorst FB, Bosma AJ, Hofland I, Winter M, Huntsman D, Jonkers J, Bahlo M,Bernards R. An α-E-catenin (CTNNA1) mutation in hereditary diffuse gastriccancer. J Pathol. 2013 Mar;229(4):621-9. doi: 10.1002/path.4152.
  8. Oliveira C, Seruca R, Hoogerbrugge N, Ligtenberg M, Carneiro F. Clinicalutility gene card for: Hereditary diffuse gastric cancer (HDGC). Eur J Hum Genet.2013 Aug;21(8). doi: 10.1038/ejhg.2012.247.
  9. Simões-Correia J, Figueiredo J, Lopes R, Stricher F, Oliveira C, Serrano L,Seruca R. E-cadherin destabilization accounts for the pathogenicity of missensemutations in hereditary diffuse gastric cancer. PLoS One. 2012;7(3):e33783. doi: 10.1371/journal.pone.0033783.
  10. van der Post RS, Vogelaar IP, Carneiro F, Guilford P, Huntsman D, HoogerbruggeN, Caldas C, Schreiber KE, Hardwick RH, Ausems MG, Bardram L, Benusiglio PR,Bisseling TM, Blair V, Bleiker E, Boussioutas A, Cats A, Coit D, DeGregorio L,Figueiredo J, Ford JM, Heijkoop E, Hermens R, Humar B, Kaurah P, Keller G, Lai J,Ligtenberg MJ, O'Donovan M, Oliveira C, Pinheiro H, Ragunath K, Rasenberg E,Richardson S, Roviello F, Schackert H, Seruca R, Taylor A, Ter Huurne A,Tischkowitz M, Joe ST, van Dijck B, van Grieken NC, van Hillegersberg R, vanSandick JW, Vehof R, van Krieken JH, Fitzgerald RC. Hereditary diffuse gastriccancer: updated clinical guidelines with an emphasis on germline CDH1 mutationcarriers. J Med Genet. 2015 Jun;52(6):361-74. doi: 10.1136/jmedgenet-2015-103094.
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