Gastrointestinal Stromal Tumor

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Xu, C. Gastrointestinal Stromal Tumor. Encyclopedia. Available online: https://encyclopedia.pub/entry/3970 (accessed on 29 September 2026).

Xu C. Gastrointestinal Stromal Tumor. Encyclopedia. Available at: https://encyclopedia.pub/entry/3970. Accessed September 29, 2026.

Xu, Camila. "Gastrointestinal Stromal Tumor" Encyclopedia, https://encyclopedia.pub/entry/3970 (accessed September 29, 2026).

Xu, C. (2020, December 23). Gastrointestinal Stromal Tumor. In Encyclopedia. https://encyclopedia.pub/entry/3970

Xu, Camila. "Gastrointestinal Stromal Tumor." Encyclopedia. Web. 23 December, 2020.

Gastrointestinal Stromal Tumor

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This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/gastrointestinal-stromal-tumor

A gastrointestinal stromal tumor (GIST) is a type of tumor that occurs in the gastrointestinal tract, most commonly in the stomach or small intestine.

genetic conditions

References

Agaram NP, Wong GC, Guo T, Maki RG, Singer S, Dematteo RP, Besmer P, AntonescuCR. Novel V600E BRAF mutations in imatinib-naive and imatinib-resistantgastrointestinal stromal tumors. Genes Chromosomes Cancer. 2008 Oct;47(10):853-9.doi: 10.1002/gcc.20589.
Heinrich MC, Corless CL, Duensing A, McGreevey L, Chen CJ, Joseph N, Singer S,Griffith DJ, Haley A, Town A, Demetri GD, Fletcher CD, Fletcher JA. PDGFRAactivating mutations in gastrointestinal stromal tumors. Science. 2003 Jan31;299(5607):708-10.
Hirota S, Isozaki K, Moriyama Y, Hashimoto K, Nishida T, Ishiguro S, Kawano K,Hanada M, Kurata A, Takeda M, Muhammad Tunio G, Matsuzawa Y, Kanakura Y,Shinomura Y, Kitamura Y. Gain-of-function mutations of c-kit in humangastrointestinal stromal tumors. Science. 1998 Jan 23;279(5350):577-80.
Hirota S, Ohashi A, Nishida T, Isozaki K, Kinoshita K, Shinomura Y, KitamuraY. Gain-of-function mutations of platelet-derived growth factor receptor alphagene in gastrointestinal stromal tumors. Gastroenterology. 2003 Sep;125(3):660-7.
Isozaki K, Terris B, Belghiti J, Schiffmann S, Hirota S, Vanderwinden JM.Germline-activating mutation in the kinase domain of KIT gene in familialgastrointestinal stromal tumors. Am J Pathol. 2000 Nov;157(5):1581-5.
Oudijk L, Gaal J, Korpershoek E, van Nederveen FH, Kelly L, Schiavon G,Verweij J, Mathijssen RH, den Bakker MA, Oldenburg RA, van Loon RL, O'SullivanMJ, de Krijger RR, Dinjens WN. SDHA mutations in adult and pediatric wild-typegastrointestinal stromal tumors. Mod Pathol. 2013 Mar;26(3):456-63. doi:10.1038/modpathol.2012.186.
Roskoski R Jr. Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor. Biochem Biophys Res Commun. 2005 Nov 11;337(1):1-13. Review.
Wagner AJ, Remillard SP, Zhang YX, Doyle LA, George S, Hornick JL. Loss ofexpression of SDHA predicts SDHA mutations in gastrointestinal stromal tumors.Mod Pathol. 2013 Feb;26(2):289-94. doi: 10.1038/modpathol.2012.153.

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Subjects: Genetics & Heredity

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Update Date: 23 Dec 2020

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