Submitted Successfully!
To reward your contribution, here is a gift for you: A free trial for our video production service.
Thank you for your contribution! You can also upload a video entry or images related to this topic.
Version Summary Created by Modification Content Size Created at Operation
1 + 390 word(s) 390 2020-12-15 07:39:18

Video Upload Options

Do you have a full video?

Confirm

Are you sure to Delete?
Cite
If you have any further questions, please contact Encyclopedia Editorial Office.
Ren, B. Stormorken syndrome. Encyclopedia. Available online: https://encyclopedia.pub/entry/3915 (accessed on 17 April 2024).
Ren B. Stormorken syndrome. Encyclopedia. Available at: https://encyclopedia.pub/entry/3915. Accessed April 17, 2024.
Ren, Bruce. "Stormorken syndrome" Encyclopedia, https://encyclopedia.pub/entry/3915 (accessed April 17, 2024).
Ren, B. (2020, December 23). Stormorken syndrome. In Encyclopedia. https://encyclopedia.pub/entry/3915
Ren, Bruce. "Stormorken syndrome." Encyclopedia. Web. 23 December, 2020.
Stormorken syndrome
Edit

Stormorken syndrome is a rare condition that affects many body systems.

genetic conditions

1. Introduction

Stormorken syndrome is a rare condition that affects many body systems. Affected individuals usually have thrombocytopenia, in which there are abnormally low numbers of blood cells called platelets. Platelets are involved in normal blood clotting; a shortage of platelets typically results in easy bruising and abnormal bleeding. In addition, affected individuals often have a muscle disorder, called tubular aggregate myopathy, that leads to muscle weakness. Another feature of Stormorken syndrome is permanent constriction of the pupils of the eyes (miosis), which may be caused by abnormalities in the muscles that control the size of the pupils. Other features include lack of a functioning spleen (asplenia), scaly skin (ichthyosis), headaches, and difficulty with reading and spelling (dyslexia).

2. Frequency

Stormorken syndrome is a rare disorder. Approximately a dozen cases have been reported in the medical literature.

3. Causes

Stormorken syndrome is caused by a mutation in the STIM1 gene. The protein produced from this gene is involved in controlling the entry of positively charged calcium atoms (calcium ions) into cells. The STIM1 protein recognizes when calcium ion levels are low and stimulates the flow of ions into the cell through special channels in the cell membrane called calcium-release activated calcium (CRAC) channels. The flow of calcium ions through CRAC channels triggers signaling within cells that helps control gene activity, cell growth and division, and immune function.

The STIM1 gene mutation involved in Stormorken syndrome leads to production of a STIM1 protein that is constantly turned on (constitutively active), which means it continually stimulates calcium ion entry through CRAC channels regardless of ion levels. Researchers suggest that the abnormal ion flow in platelets causes them to break down earlier than usual, leading to thrombocytopenia and bleeding problems in people with Stormorken syndrome. It is unknown how constitutively active STIM1 leads to the other features of the disorder.

4. Inheritance

This condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. In some cases, an affected person inherits the mutation from one affected parent. Other cases result from new mutations in the gene and occur in people with no history of the disorder in their family.

5. Other Names for This Condition

  • Stormorken-Sjaastad-Langslet syndrome
  • thrombocytopathy, asplenia, and miosis

References

  1. Kilch T, Alansary D, Peglow M, Dörr K, Rychkov G, Rieger H, Peinelt C,Niemeyer BA. Mutations of the Ca2+-sensing stromal interaction molecule STIM1regulate Ca2+ influx by altered oligomerization of STIM1 and by destabilizationof the Ca2+ channel Orai1. J Biol Chem. 2013 Jan 18;288(3):1653-64. doi:10.1074/jbc.M112.417246.
  2. Misceo D, Holmgren A, Louch WE, Holme PA, Mizobuchi M, Morales RJ, De PaulaAM, Stray-Pedersen A, Lyle R, Dalhus B, Christensen G, Stormorken H, TjønnfjordGE, Frengen E. A dominant STIM1 mutation causes Stormorken syndrome. Hum Mutat.2014 May;35(5):556-64. doi: 10.1002/humu.22544.
  3. Morin G, Bruechle NO, Singh AR, Knopp C, Jedraszak G, Elbracht M,Brémond-Gignac D, Hartmann K, Sevestre H, Deutz P, Hérent D, Nürnberg P, Roméo B,Konrad K, Mathieu-Dramard M, Oldenburg J, Bourges-Petit E, Shen Y, Zerres K,Ouadid-Ahidouch H, Rochette J. Gain-of-Function Mutation in STIM1 (P.R304W) IsAssociated with Stormorken Syndrome. Hum Mutat. 2014 Oct;35(10):1221-32. doi:10.1002/humu.22621.
  4. Nesin V, Wiley G, Kousi M, Ong EC, Lehmann T, Nicholl DJ, Suri M, Shahrizaila N, Katsanis N, Gaffney PM, Wierenga KJ, Tsiokas L. Activating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4197-202. doi:10.1073/pnas.1312520111.
  5. Parekh AB. Local Ca2+ influx through CRAC channels activates temporally andspatially distinct cellular responses. Acta Physiol (Oxf). 2009 Jan;195(1):29-35.doi: 10.1111/j.1748-1716.2008.01919.x.
  6. Stormorken H, Sjaastad O, Langslet A, Sulg I, Egge K, Diderichsen J. A newsyndrome: thrombocytopathia, muscle fatigue, asplenia, miosis, migraine, dyslexiaand ichthyosis. Clin Genet. 1985 Nov;28(5):367-74.
  7. Zhou Y, Meraner P, Kwon HT, Machnes D, Oh-hora M, Zimmer J, Huang Y, Stura A, Rao A, Hogan PG. STIM1 gates the store-operated calcium channel ORAI1 in vitro.Nat Struct Mol Biol. 2010 Jan;17(1):112-6. doi: 10.1038/nsmb.1724.
More
Information
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register :
View Times: 541
Entry Collection: MedlinePlus
Revision: 1 time (View History)
Update Date: 23 Dec 2020
1000/1000