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HandWiki. Immunological Constant of Rejection. Encyclopedia. Available online: https://encyclopedia.pub/entry/37556 (accessed on 26 September 2026).
HandWiki. Immunological Constant of Rejection. Encyclopedia. Available at: https://encyclopedia.pub/entry/37556. Accessed September 26, 2026.
HandWiki. "Immunological Constant of Rejection" Encyclopedia, https://encyclopedia.pub/entry/37556 (accessed September 26, 2026).
HandWiki. (2022, December 01). Immunological Constant of Rejection. In Encyclopedia. https://encyclopedia.pub/entry/37556
HandWiki. "Immunological Constant of Rejection." Encyclopedia. Web. 01 December, 2022.
Immunological Constant of Rejection
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The content is sourced from: https://handwiki.org/wiki/Biology:Immunological_constant_of_rejection

The Immunologic Constant of Rejection (ICR), is a notion introduced by biologists to group a shared set of genes expressed in tissue destructive-pathogenic conditions like cancer and infection, along a diverse set of physiological circumstances of tissue damage or organ failure, including autoimmune disease or allograft rejection. The identification of shared mechanisms and phenotypes by distinct immune pathologies, marked as a hallmarks or biomarkers, aids in the identification of novel treatment options, without necessarily assessing patients phenomenologies individually.

rejection allograft icr

References

  1. "The immunologic constant of rejection". Trends in Immunology 29 (6): 256–62. June 2008. doi:10.1016/j.it.2008.03.002. PMID 18457994.  https://dx.doi.org/10.1016%2Fj.it.2008.03.002
  2. "Prognostic and predictive immune gene signatures in breast cancer". Current Opinion in Oncology 27 (6): 433–44. November 2015. doi:10.1097/CCO.0000000000000234. PMID 26418235.  https://dx.doi.org/10.1097%2FCCO.0000000000000234
  3. "Disentangling the relationship between tumor genetic programs and immune responsiveness". Current Opinion in Immunology 39: 150–8. April 2016. doi:10.1016/j.coi.2016.02.001. PMID 26967649.  https://dx.doi.org/10.1016%2Fj.coi.2016.02.001
  4. "Identification of genetic determinants of breast cancer immune phenotypes by integrative genome-scale analysis". Oncoimmunology 6 (2): e1253654. 2017. doi:10.1080/2162402X.2016.1253654. PMID 28344865.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5353940
  5. "The immunologic constant of rejection classification refines the prognostic value of conventional prognostic signatures in breast cancer". British Journal of Cancer 119 (11): 1383–1391. November 2018. doi:10.1038/s41416-018-0309-1. PMID 30353048.  https://dx.doi.org/10.1038%2Fs41416-018-0309-1
  6. "Oncogenic states dictate the prognostic and predictive connotations of intratumoral immune response". Journal for ImmunoTherapy of Cancer 8 (1): e000617. May 2020. doi:10.1136/jitc-2020-000617. PMID 32376723.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=7223637
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