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HandWiki. ZIP9. Encyclopedia. Available online: https://encyclopedia.pub/entry/35577 (accessed on 27 September 2026).
HandWiki. ZIP9. Encyclopedia. Available at: https://encyclopedia.pub/entry/35577. Accessed September 27, 2026.
HandWiki. "ZIP9" Encyclopedia, https://encyclopedia.pub/entry/35577 (accessed September 27, 2026).
HandWiki. (2022, November 21). ZIP9. In Encyclopedia. https://encyclopedia.pub/entry/35577
HandWiki. "ZIP9." Encyclopedia. Web. 21 November, 2022.
ZIP9
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The content is sourced from: https://handwiki.org/wiki/Biology:ZIP9

Zinc transporter ZIP9 also known as Zrt- and Irt-like protein 9 (ZIP9) and solute carrier family 39 member 9 (SLC39A9) is a protein that in humans is encoded by the SLC39A9 gene. This protein is the 9th member out of 14 ZIP family proteins, which is a membrane androgen receptor (mAR) coupled to G proteins, and also classified as a zinc transporter protein. ZIP family proteins transport zinc metal from the extracellular environment into cells through cell membrane.

solute carrier zinc transporter slc39a9

References

  1. "The ZIP family of metal transporters". Biochimica et Biophysica Acta 1465 (1-2): 190–8. 2000. doi:10.1016/S0005-2736(00)00138-3. PMID 10748254.  https://dx.doi.org/10.1016%2FS0005-2736%2800%2900138-3
  2. "Mammalian zinc transporters: nutritional and physiologic regulation". Annual Review of Nutrition 29 (1): 153–76. 2009-07-22. doi:10.1146/annurev-nutr-033009-083312. PMID 19400752.  https://dx.doi.org/10.1146%2Fannurev-nutr-033009-083312
  3. "SLC39A9 (ZIP9) regulates zinc homeostasis in the secretory pathway: characterization of the ZIP subfamily I protein in vertebrate cells". Bioscience, Biotechnology, and Biochemistry 73 (5): 1142–8. May 2009. doi:10.1271/bbb.80910. PMID 19420709.  https://dx.doi.org/10.1271%2Fbbb.80910
  4. Universal protein resource accession number Q9NUM3 at UniProt. https://www.uniprot.org/uniprot/Q9NUM3
  5. "Characterization of two nuclear androgen receptors in Atlantic croaker: comparison of their biochemical properties and binding specificities". Endocrinology 140 (4): 1602–11. April 1999. doi:10.1210/endo.140.4.6631. PMID 10098494.  https://dx.doi.org/10.1210%2Fendo.140.4.6631
  6. "Androgens inhibit estradiol-17beta synthesis in Atlantic croaker (Micropogonias undulatus) ovaries by a nongenomic mechanism initiated at the cell surface". Biology of Reproduction 69 (5): 1642–50. November 2003. doi:10.1095/biolreprod.103.015479. PMID 12855603.  https://dx.doi.org/10.1095%2Fbiolreprod.103.015479
  7. "The Zip Family of Zinc Transporters". Zinc Finger Proteins.. Boston, MA: Molecular Biology Intelligence Unit. Springer. 2005. doi:10.1007/0-387-27421-9_35.  https://dx.doi.org/10.1007%2F0-387-27421-9_35
  8. "Identification and characterization of membrane androgen receptors in the ZIP9 zinc transporter subfamily: I. Discovery in female atlantic croaker and evidence ZIP9 mediates testosterone-induced apoptosis of ovarian follicle cells". Endocrinology 155 (11): 4237–49. November 2014. doi:10.1210/en.2014-1198. PMID 25014354.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4197986
  9. "Zebrafish in the sea of mineral (iron, zinc, and copper) metabolism". Frontiers in Pharmacology 5: 33. 2014. doi:10.3389/fphar.2014.00033. PMID 24639652.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3944790
  10. "Identification and characterization of membrane androgen receptors in the ZIP9 zinc transporter subfamily: II. Role of human ZIP9 in testosterone-induced prostate and breast cancer cell apoptosis". Endocrinology 155 (11): 4250–65. November 2014. doi:10.1210/en.2014-1201. PMID 25014355.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4197988
  11. "ZIP9, a novel membrane androgen receptor and zinc transporter protein". General and Comparative Endocrinology. May 2017. doi:10.1016/j.ygcen.2017.04.016. PMID 28479083.  https://dx.doi.org/10.1016%2Fj.ygcen.2017.04.016
  12. "Testosterone/bicalutamide antagonism at the predicted extracellular androgen binding site of ZIP9". Biochim. Biophys. Acta 1864 (12): 2402–2414. 2017. doi:10.1016/j.bbamcr.2017.09.012. PMID 28943399.  https://dx.doi.org/10.1016%2Fj.bbamcr.2017.09.012
  13. "Essential role of the zinc transporter ZIP9/SLC39A9 in regulating the activations of Akt and Erk in B-cell receptor signaling pathway in DT40 cells". PLoS One 8 (3): e58022. 2013. doi:10.1371/journal.pone.0058022. PMID 23505453.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3591455
  14. "Zinc and insulin in pancreatic beta-cells". Endocrine 45 (2): 178–89. March 2014. doi:10.1007/s12020-013-0032-x. PMID 23979673.  https://dx.doi.org/10.1007%2Fs12020-013-0032-x
  15. "Unzipping androgen action through ZIP9: a novel membrane androgen receptor". Endocrinology 155 (11): 4120–3. November 2014. doi:10.1210/en.2014-1749. PMID 25325426.  https://dx.doi.org/10.1210%2Fen.2014-1749
  16. "Biallelic inactivation of TRAF3 in a subset of B-cell lymphomas with interstitial del (14)(q24. 1 q32. 33).". Leukemia 23 (11): 2153–2156. August 2009. doi:10.1038/leu.2009.149. PMID 19693093.  https://dx.doi.org/10.1038%2Fleu.2009.149
  17. "Biallelic inactivation of TRAF3 in a subset of B-cell lymphomas with interstitial del (14)(q24. 1 q32. 33)". 
  18. "Formation of chimeric genes by copy-number variation as a mutational mechanism in schizophrenia.". The American Journal of Human Genetics 93 (4): 697–710. October 2013. doi:10.1016/j.ajhg.2013.09.004. PMID 24094746.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3791253
  19. "Formation of chimeric genes by copy-number variation as a mutational mechanism in schizophrenia.". 
  20. "Recurrent fusion transcripts detected by whole‐transcriptome sequencing of 120 primary breast cancer samples.". Genes, Chromosomes and Cancer 54 (11): 681–691. November 2015. doi:10.1002/gcc.22279. PMID 26227178.  https://dx.doi.org/10.1002%2Fgcc.22279
  21. "Recurrent fusion transcripts detected by whole‐transcriptome sequencing of 120 primary breast cancer samples.". 
  22. "Expression of the zinc importer protein ZIP9/SLC39A9 in glioblastoma cells affects phosphorylation states of p53 and GSK-3β and causes increased cell migration". Biometals 29 (6): 995–1004. December 2016. doi:10.1007/s10534-016-9971-z. PMID 27654922.  https://dx.doi.org/10.1007%2Fs10534-016-9971-z
  23. "Zinc and its transporters, pancreatic β-cells, and insulin metabolism". Vitamins and Hormones 95: 365–90. doi:10.1016/b978-0-12-800174-5.00014-4. PMID 24559925.  https://dx.doi.org/10.1016%2Fb978-0-12-800174-5.00014-4
  24. "Expression of the ZIP/SLC39A transporters in β-cells: a systematic review and integration of multiple datasets". BMC Genomics 18 (1): 719. September 2017. doi:10.1186/s12864-017-4119-2. PMID 28893192.  https://dx.doi.org/10.1186%2Fs12864-017-4119-2
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