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HandWiki. TLR2. Encyclopedia. Available online: https://encyclopedia.pub/entry/34367 (accessed on 26 September 2026).
HandWiki. TLR2. Encyclopedia. Available at: https://encyclopedia.pub/entry/34367. Accessed September 26, 2026.
HandWiki. "TLR2" Encyclopedia, https://encyclopedia.pub/entry/34367 (accessed September 26, 2026).
HandWiki. (2022, November 14). TLR2. In Encyclopedia. https://encyclopedia.pub/entry/34367
HandWiki. "TLR2." Encyclopedia. Web. 14 November, 2022.
TLR2
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The content is sourced from: https://handwiki.org/wiki/Biology:TLR2

Toll-like receptor 2 also known as TLR2 is a protein that in humans is encoded by the TLR2 gene. TLR2 has also been designated as CD282 (cluster of differentiation 282). TLR2 is one of the toll-like receptors and plays a role in the immune system. TLR2 is a membrane protein, a receptor, which is expressed on the surface of certain cells and recognizes foreign substances and passes on appropriate signals to the cells of the immune system.

toll-like receptors tlr2 cd282

References

  1. "TLR2: a crossroads between infections and autoimmunity?". International Journal of Immunopathology and Pharmacology 24 (3): 549–56. 2011. doi:10.1177/039463201102400301. PMID 21978687.  https://dx.doi.org/10.1177%2F039463201102400301
  2. "Entrez Gene: TLR2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7097. 
  3. "TLR2 controls intestinal carcinogen detoxication by CYP1A1". PLOS ONE 7 (3): e32309. 2012. doi:10.1371/journal.pone.0032309. PMID 22442665. Bibcode: 2012PLoSO...732309D.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3307708
  4. "Oral benzo[a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate". Molecular Pharmacology 69 (4): 1103–14. April 2006. doi:10.1124/mol.105.021501. PMID 16377763.  https://dx.doi.org/10.1124%2Fmol.105.021501
  5. "Barrier-protective function of intestinal epithelial Toll-like receptor 2". Mucosal Immunology Suppl 1: S62-6. Nov 2008. doi:10.1038/mi.2008.47. PMID 19079234.  https://dx.doi.org/10.1038%2Fmi.2008.47
  6. "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes.". J Cell Physiol 230 (4): 802–812. April 2015. doi:10.1002/jcp.24808. PMID 25205602.  https://dx.doi.org/10.1002%2Fjcp.24808
  7. Leoni, Valerio; Gianni, Tatiana; Salvioli, Stefano; Campadelli-Fiume, Gabriella (2012-06-15). "Herpes Simplex Virus Glycoproteins gH/gL and gB Bind Toll-Like Receptor 2, and Soluble gH/gL Is Sufficient To Activate NF-κB" (in en). Journal of Virology 86 (12): 6555–6562. doi:10.1128/JVI.00295-12. ISSN 0022-538X. PMID 22496225.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3393584
  8. "Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins". Journal of Immunology 169 (1): 10–4. July 2002. doi:10.4049/jimmunol.169.1.10. PMID 12077222.  https://dx.doi.org/10.4049%2Fjimmunol.169.1.10
  9. "Negative regulation of toll-like receptor-mediated signaling by Tollip". The Journal of Biological Chemistry 277 (9): 7059–65. March 2002. doi:10.1074/jbc.M109537200. PMID 11751856.  https://dx.doi.org/10.1074%2Fjbc.M109537200
  10. "The structural biology of Toll-like receptors". Structure 19 (4): 447–59. April 2011. doi:10.1016/j.str.2011.02.004. PMID 21481769.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3075535
  11. "Proinflammatory responses by glycosylphosphatidylinositols (GPIs) of Plasmodium falciparum are mainly mediated through the recognition of TLR2/TLR1". Experimental Parasitology 128 (3): 205–11. July 2011. doi:10.1016/j.exppara.2011.03.010. PMID 21439957.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3100359
  12. "Structure and dynamic behavior of Toll-like receptor 2 subfamily triggered by malarial glycosylphosphatidylinositols of Plasmodium falciparum". The FEBS Journal 280 (23): 6196–212. December 2013. doi:10.1111/febs.12541. PMID 24090058.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4163636
  13. "Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease". The Lancet. Infectious Diseases 5 (3): 156–64. March 2005. doi:10.1016/S1473-3099(05)01308-3. PMID 15766650.  https://dx.doi.org/10.1016%2FS1473-3099%2805%2901308-3
  14. "Polymorphisms of the toll-like receptor 2 and 4 genes are associated with faster progression and a more severe course of sepsis in critically ill patients". The Journal of International Medical Research 42 (1): 93–110. February 2014. doi:10.1177/0300060513504358. PMID 24366499.  https://dx.doi.org/10.1177%2F0300060513504358
  15. "Lack of association between Toll-like receptor 2 polymorphisms and susceptibility to severe disease caused by Staphylococcus aureus". Clinical and Diagnostic Laboratory Immunology 11 (6): 1194–7. November 2004. doi:10.1128/CDLI.11.6.1194-1197.2004. PMID 15539529.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=524778
  16. "Toll-Like Receptor 2 Promoter -196 to -174 Deletion Affects CD4 Levels Along Human Immunodeficiency Virus Infection Progression". Journal of Infectious Diseases 222 (12): 2007–2011. December 2020. doi:10.1093/infdis/jiaa327. PMID 32516401.  https://dx.doi.org/10.1093%2Finfdis%2Fjiaa327
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