Your browser does not fully support modern features. Please upgrade for a smoother experience.
Submitted Successfully!
Thank you for your contribution! You can also upload a video entry or images related to this topic. For video creation, please contact our Academic Video Service.
Version Summary Created by Modification Content Size Created at Operation
1 handwiki Dean Liu -- 2284 2022-11-07 01:40:52

Video Upload Options

We provide professional Academic Video Service to translate complex research into visually appealing presentations. Would you like to try it?
Cite
If you have any further questions, please contact Encyclopedia Editorial Office.
HandWiki. Severe Acute Respiratory Syndrome–Related Coronavirus. Encyclopedia. Available online: https://encyclopedia.pub/entry/33265 (accessed on 25 September 2026).
HandWiki. Severe Acute Respiratory Syndrome–Related Coronavirus. Encyclopedia. Available at: https://encyclopedia.pub/entry/33265. Accessed September 25, 2026.
HandWiki. "Severe Acute Respiratory Syndrome–Related Coronavirus" Encyclopedia, https://encyclopedia.pub/entry/33265 (accessed September 25, 2026).
HandWiki. (2022, November 07). Severe Acute Respiratory Syndrome–Related Coronavirus. In Encyclopedia. https://encyclopedia.pub/entry/33265
HandWiki. "Severe Acute Respiratory Syndrome–Related Coronavirus." Encyclopedia. Web. 07 November, 2022.
Severe Acute Respiratory Syndrome–Related Coronavirus
Edit

Severe acute respiratory syndrome–related coronavirus (SARSr-CoV or SARS-CoV)[note 1] is a species of virus consisting of many known strains phylogenetically related to severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) that have been shown to possess the capability to infect humans, bats, and certain other mammals. These enveloped, positive-sense single-stranded RNA viruses enter host cells by binding to the angiotensin-converting enzyme 2 (ACE2) receptor. The SARSr-CoV species is a member of the genus Betacoronavirus and of the subgenus Sarbecovirus (SARS Betacoronavirus). Two strains of the virus have caused outbreaks of severe respiratory diseases in humans: severe acute respiratory syndrome coronavirus 1 (SARS-CoV or SARS-CoV-1), which caused the 2002–2004 outbreak of severe acute respiratory syndrome (SARS), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is causing the ongoing pandemic of COVID-19. There are hundreds of other strains of SARSr-CoV, which are only known to infect non-human species: bats are a major reservoir of many strains of SARSr-CoV; several strains have been identified in palm civets, which were likely ancestors of SARS-CoV-1. The SARS-related coronavirus was one of several viruses identified by the World Health Organization (WHO) in 2016 as a likely cause of a future epidemic in a new plan developed after the Ebola epidemic for urgent research and development before and during an epidemic towards diagnostic tests, vaccines and medicines. This prediction came to pass with the COVID-19 pandemic. Such development, if incorporating "nucleic acids coding for SARS-CoV virulence factors," which is listed on the Federal Select Agents and Toxins List, is expressly illegal in the United States per U.S. Federal Code 7 CFR Part 331, U.S. Federal Code 9 CFR Part 121, U.S. Federal Code 42 CFR Part 73, and 18 U.S. Code Section 178. The Statutes provide a legal remedy of 99 years in federal prison and up to $100,000,000 penalty per felony count. On March 3, 2022 a federal case was filed in the State of Utah seeking clarification of the legal status of Covid-19 gene therapies under these existing statutes, and the case is currently pending.

virulence health coronavirus 1

References

  1. "Global Epidemiology of Bat Coronaviruses". Viruses 11 (2): 174. February 2019. doi:10.3390/v11020174. PMID 30791586. "See Figure 1.".  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=6409556
  2. "Coronavirus genomics and bioinformatics analysis". Viruses 2 (8): 1804–20. August 2010. doi:10.3390/v2081803. PMID 21994708. "See Figure 1.".  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3185738
  3. "Coronavirus genomics and bioinformatics analysis". Viruses 2 (8): 1804–20. August 2010. doi:10.3390/v2081803. PMID 21994708. "Furthermore, subsequent phylogenetic analysis using both complete genome sequence and proteomic approaches, it was concluded that SARSr-CoV is probably an early split-off from the Betacoronavirus lineage [1]; See Figure 2.".  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3185738
  4. "Coronaviridae - Figures - Positive Sense RNA Viruses - Positive Sense RNA Viruses (2011)" (in en). International Committee on Taxonomy of Viruses (ICTV). https://talk.ictvonline.org/ictv-reports/ictv_9th_report/positive-sense-rna-viruses-2011/w/posrna_viruses/223/coronaviridae-figures. "See Figure 2." 
  5. "SARS-Coronavirus ancestor's foot-prints in South-East Asian bat colonies and the refuge theory". Infection, Genetics and Evolution 11 (7): 1690–702. October 2011. doi:10.1016/j.meegid.2011.06.021. PMID 21763784. "Betacoronaviruses-b ancestors, meaning SARSr-CoVs ancestors, could have been historically hosted by the common ancestor of the Rhinolophidae and Hipposideridae and could have later evolved independently in the lineages leading towards Rhinolophidae and Hipposideridae betacoronaviruses.".  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=7106191
  6. "Evolutionary relationships between bat coronaviruses and their hosts". Emerging Infectious Diseases 13 (10): 1526–32. October 2007. doi:10.3201/eid1310.070448. PMID 18258002.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2851503
  7. "Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor". Nature 503 (7477): 535–8. November 2013. doi:10.1038/nature12711. PMID 24172901. Bibcode: 2013Natur.503..535G.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5389864
  8. Coronaviridae Study Group of the International Committee on Taxonomy of Viruses (March 2020). "The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2". Nature Microbiology 5 (4): 536–544. doi:10.1038/s41564-020-0695-z. PMID 32123347.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=7095448
  9. "Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage". Journal of Molecular Biology 331 (5): 991–1004. August 2003. doi:10.1016/S0022-2836(03)00865-9. PMID 12927536. "The SARS-CoV genome is ∼29.7 kb long and contains 14 open reading frames (ORFs) flanked by 5′ and 3′-untranslated regions of 265 and 342 nucleotides, respectively (Figure 1).".  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=7159028
  10. Maier, Helena Jane; Bickerton, Erica; Britton, Paul, eds (2015). "Coronaviruses: an overview of their replication and pathogenesis". Coronaviruses. Methods in Molecular Biology. 1282. Springer. pp. 1–23. doi:10.1007/978-1-4939-2438-7_1. ISBN 978-1-4939-2438-7.  https://dx.doi.org/10.1007%2F978-1-4939-2438-7_1
  11. Maier, Helena Jane; Bickerton, Erica; Britton, Paul, eds (2015). An Overview of Their Replication and Pathogenesis; Section 2 Genomic Organization. Methods in Molecular Biology. 1282. Springer. pp. 1–23. doi:10.1007/978-1-4939-2438-7_1. ISBN 978-1-4939-2438-7.  https://dx.doi.org/10.1007%2F978-1-4939-2438-7_1
  12. "The role of severe acute respiratory syndrome (SARS)-coronavirus accessory proteins in virus pathogenesis". Viruses 4 (11): 2902–23. November 2012. doi:10.3390/v4112902. PMID 23202509. "See Table 1.".  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3509677
  13. "Differential stepwise evolution of SARS coronavirus functional proteins in different host species". BMC Evolutionary Biology 9: 52. March 2009. doi:10.1186/1471-2148-9-52. PMID 19261195.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2676248
  14. Narayanan, Krishna; Huang, Cheng; Makino, Shinji (April 2008). "SARS coronavirus Accessory Proteins". Virus Research 133 (1): 113–121. doi:10.1016/j.virusres.2007.10.009. ISSN 0168-1702. PMID 18045721. "See Table 1.".  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2720074
  15. Redondo, Natalia; Zaldívar-López, Sara; Garrido, Juan J.; Montoya, Maria (7 July 2021). "SARS-CoV-2 Accessory Proteins in Viral Pathogenesis: Knowns and Unknowns". Frontiers in Immunology 12: 708264. doi:10.3389/fimmu.2021.708264. PMID 34305949.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=8293742
  16. "The role of severe acute respiratory syndrome (SARS)-coronavirus accessory proteins in virus pathogenesis". Viruses 4 (11): 2902–23. November 2012. doi:10.3390/v4112902. PMID 23202509.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3509677
  17. "Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage". Journal of Molecular Biology 331 (5): 991–1004. August 2003. doi:10.1016/S0022-2836(03)00865-9. PMID 12927536. "See Figure 1.".  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=7159028
  18. Kaina, Bernd (2021). "On the Origin of SARS-CoV-2: Did Cell Culture Experiments Lead to Increased Virulence of the Progenitor Virus for Humans?". In Vivo 35 (3): 1313–1326. doi:10.21873/invivo.12384. PMID 33910809.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=8193286
  19. Lu R, Zhao X, Li J, Niu P, Yang B, Wu H (2020). "Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.". Lancet 395 (10224): 565–574. doi:10.1016/S0140-6736(20)30251-8. PMID 32007145.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=7159086
  20. Coronaviridae Study Group of the International Committee on Taxonomy of Viruses (2020). "The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2.". Nat Microbiol 5 (4): 536–544. doi:10.1038/s41564-020-0695-z. PMID 32123347.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=7095448
  21. Alexander, Jeffrey C.; Jacobs, Ronald N.; Smith, Philip, eds (December 2020). "A virus as an icon: the 2020 pandemic in images". American Journal of Cultural Sociology (Basingstoke: Palgrave Macmillan) 8 (3: The COVID Crisis and Cultural Sociology: Alone Together): 451–461. doi:10.1057/s41290-020-00118-7. ISSN 2049-7113. PMID 33042541. PMC 7537773. https://link.springer.com/content/pdf/10.1057/s41290-020-00118-7.pdf. 
  22. "Ultrastructural characterization of SARS coronavirus". Emerging Infectious Diseases 10 (2): 320–6. February 2004. doi:10.3201/eid1002.030913. PMID 15030705. "Virions acquired an envelope by budding into the cisternae and formed mostly spherical, sometimes pleomorphic, particles that averaged 78 nm in diameter (Figure 1A).".  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3322934
  23. "Supramolecular architecture of severe acute respiratory syndrome coronavirus revealed by electron cryomicroscopy". Journal of Virology 80 (16): 7918–28. August 2006. doi:10.1128/JVI.00645-06. PMID 16873249. "Particle diameters ranged from 50 to 150 nm, excluding the spikes, with mean particle diameters of 82 to 94 nm; Also See Figure 1 for double shell.".  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1563832
  24. "The molecular biology of coronaviruses". Advances in Virus Research 48: 1–100. 1997. doi:10.1016/S0065-3527(08)60286-9. ISBN 9780120398485. PMID 9233431.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=7130985
  25. The molecular biology of coronaviruses. Advances in Virus Research. 66. Academic Press. 1 January 2006. pp. 193–292. doi:10.1016/S0065-3527(06)66005-3. ISBN 9780120398690. "Nevertheless, the interaction between S protein and receptor remains the principal, if not sole, determinant of coronavirus host species range and tissue tropism."  https://dx.doi.org/10.1016%2FS0065-3527%2806%2966005-3
  26. "Origin and evolution of pathogenic coronaviruses". Nature Reviews. Microbiology 17 (3): 181–192. March 2019. doi:10.1038/s41579-018-0118-9. PMID 30531947. "Different SARS-CoV strains isolated from several hosts vary in their binding affinities for human ACE2 and consequently in their infectivity of human cells76,78 (Fig. 6b)".  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=7097006
  27. Maier, Helena Jane; Bickerton, Erica; Britton, Paul, eds (2015). An Overview of Their Replication and Pathogenesis; Section 2 Genomic Organization. Methods in Molecular Biology. 1282. Springer. pp. 1–23. doi:10.1007/978-1-4939-2438-7_1. ISBN 978-1-4939-2438-7. "See section: Virion Structure."  https://dx.doi.org/10.1007%2F978-1-4939-2438-7_1
  28. "The SARS coronavirus nucleocapsid protein--forms and functions". Antiviral Research 103: 39–50. March 2014. doi:10.1016/j.antiviral.2013.12.009. PMID 24418573. "See Figure 4c.".  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=7113676
  29. "A structural analysis of M protein in coronavirus assembly and morphology". Journal of Structural Biology 174 (1): 11–22. April 2011. doi:10.1016/j.jsb.2010.11.021. PMID 21130884. "See Figure 10.".  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4486061
  30. Lal, Sunil K, ed (2010). Molecular Biology of the SARS-Coronavirus. doi:10.1007/978-3-642-03683-5. ISBN 978-3-642-03682-8.  https://dx.doi.org/10.1007%2F978-3-642-03683-5
  31. Maier, Helena Jane; Bickerton, Erica; Britton, Paul, eds (2015). "Coronaviruses: an overview of their replication and pathogenesis". Coronaviruses. Methods in Molecular Biology. 1282. Springer. pp. 1–23. doi:10.1007/978-1-4939-2438-7_1. ISBN 978-1-4939-2438-7. "See section: Coronavirus Life Cycle – Attachment and Entry"  https://dx.doi.org/10.1007%2F978-1-4939-2438-7_1
  32. "Proteolytic activation of the SARS-coronavirus spike protein: cutting enzymes at the cutting edge of antiviral research". Antiviral Research 100 (3): 605–14. December 2013. doi:10.1016/j.antiviral.2013.09.028. PMID 24121034. "See Figure 2.".  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3889862
  33. Starr, Tyler N.; Zepeda, Samantha K.; Walls, Alexandra C.; Greaney, Allison J.; Alkhovsky, Sergey; Veesler, David; Bloom, Jesse D. (2022-03-01). "ACE2 binding is an ancestral and evolvable trait of sarbecoviruses" (in en). Nature 603 (7903): 1–6. doi:10.1038/s41586-022-04464-z. ISSN 1476-4687. https://www.nature.com/articles/s41586-022-04464-z. 
  34. "TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein". Journal of Virology 88 (2): 1293–307. January 2014. doi:10.1128/JVI.02202-13. PMID 24227843. "The SARS-CoV can hijack two cellular proteolytic systems to ensure the adequate processing of its S protein. Cleavage of SARS-S can be facilitated by cathepsin L, a pH-dependent endo-/lysosomal host cell protease, upon uptake of virions into target cell endosomes (25). Alternatively, the type II transmembrane serine proteases (TTSPs) TMPRSS2 and HAT can activate SARS-S, presumably by cleavage of SARS-S at or close to the cell surface, and activation of SARS-S by TMPRSS2 allows for cathepsin L-independent cellular entry (26,–28).".  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3911672
  35. "Coronaviruses - drug discovery and therapeutic options". Nature Reviews. Drug Discovery 15 (5): 327–47. May 2016. doi:10.1038/nrd.2015.37. PMID 26868298. "S is activated and cleaved into the S1 and S2 subunits by other host proteases, such as transmembrane protease serine 2 (TMPRSS2) and TMPRSS11D, which enables cell surface non-endosomal virus entry at the plasma membrane.".  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=7097181
  36. "The human coronavirus HCoV-229E S-protein structure and receptor binding". eLife 8. October 2019. doi:10.7554/eLife.51230. PMID 31650956.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=6970540
  37. Maier, Helena Jane; Bickerton, Erica; Britton, Paul, eds (2015). "Coronaviruses: an overview of their replication and pathogenesis". Coronaviruses. Methods in Molecular Biology. 1282. Springer. pp. 1–23. doi:10.1007/978-1-4939-2438-7_1. ISBN 978-1-4939-2438-7. "See Table 2."  https://dx.doi.org/10.1007%2F978-1-4939-2438-7_1
  38. "The molecular biology of coronaviruses". Advances in Virus Research (Academic Press) 66: 193–292. 1 January 2006. doi:10.1016/S0065-3527(06)66005-3. ISBN 9780120398690. PMID 16877062. "See Figure 8.".  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=7112330
  39. Maier, Helena Jane; Bickerton, Erica; Britton, Paul, eds (2015). "Coronaviruses: an overview of their replication and pathogenesis". Coronaviruses. Methods in Molecular Biology. 1282. Springer. pp. 1–23. doi:10.1007/978-1-4939-2438-7_1. ISBN 978-1-4939-2438-7. "See section: Replicase Protein Expression"  https://dx.doi.org/10.1007%2F978-1-4939-2438-7_1
  40. Mehdi Moustaqil (5 June 2020). "SARS-CoV-2 proteases cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species and the search for reservoir hosts". bioRxiv: 2020.06.05.135699. doi:10.1101/2020.06.05.135699. https://www.biorxiv.org/content/10.1101/2020.06.05.135699v1. 
  41. "Homology-Based Identification of a Mutation in the Coronavirus RNA-Dependent RNA Polymerase That Confers Resistance to Multiple Mutagens". Journal of Virology 90 (16): 7415–28. August 2016. doi:10.1128/JVI.00080-16. PMID 27279608. "Finally, these results, combined with those from previous work (33, 44), suggest that CoVs encode at least three proteins involved in fidelity (nsp12-RdRp, nsp14-ExoN, and nsp10), supporting the assembly of a multiprotein replicase-fidelity complex, as described previously (38).".  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4984655
  42. Maier, Helena Jane; Bickerton, Erica; Britton, Paul, eds (2015). "Coronaviruses: an overview of their replication and pathogenesis". Coronaviruses. Methods in Molecular Biology. 1282. Springer. pp. 1–23. doi:10.1007/978-1-4939-2438-7_1. ISBN 978-1-4939-2438-7. "See section: Corona Life Cycle – Replication and Transcription"  https://dx.doi.org/10.1007%2F978-1-4939-2438-7_1
  43. Maier, Helena Jane; Bickerton, Erica; Britton, Paul, eds (2015). "Coronaviruses: an overview of their replication and pathogenesis". Coronaviruses. Methods in Molecular Biology. 1282. Springer. pp. 1–23. doi:10.1007/978-1-4939-2438-7_1. ISBN 978-1-4939-2438-7. "See Figure 1."  https://dx.doi.org/10.1007%2F978-1-4939-2438-7_1
  44. Zhang XW, Yap YL, Danchin A. Testing the hypothesis of a recombinant origin of the SARS-associated coronavirus. Arch Virol. 2005 Jan;150(1):1-20. Epub 2004 Oct 11. PMID 15480857
  45. Stanhope MJ, Brown JR, Amrine-Madsen H. Evidence from the evolutionary analysis of nucleotide sequences for a recombinant history of SARS-CoV. Infect Genet Evol. 2004 Mar;4(1):15-9. PMID 15019585
  46. Maier, Helena Jane; Bickerton, Erica; Britton, Paul, eds (2015). "Coronaviruses: an overview of their replication and pathogenesis". Coronaviruses. Methods in Molecular Biology. 1282. Springer. pp. 1–23. doi:10.1007/978-1-4939-2438-7_1. ISBN 978-1-4939-2438-7. "See section: Coronavirus Life Cycle – Assembly and Release"  https://dx.doi.org/10.1007%2F978-1-4939-2438-7_1
More
Upload a video for this entry
Information
Subjects: Microbiology
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register :
View Times: 954
Entry Collection: HandWiki
Revision: 1 time (View History)
Update Date: 07 Nov 2022
Notice
You are not a member of the advisory board for this topic. If you want to update advisory board member profile, please contact office@encyclopedia.pub.
OK
Confirm
Only members of the Encyclopedia advisory board for this topic are allowed to note entries. Would you like to become an advisory board member of the Encyclopedia?
Yes
No
${ textCharacter }/${ maxCharacter }
Submit
Cancel
There is no comment~
${ textCharacter }/${ maxCharacter }
Submit
Cancel
${ selectedItem.replyTextCharacter }/${ selectedItem.replyMaxCharacter }
Submit
Cancel
Confirm
Are you sure to Delete?
Yes No
Academic Video Service