Metal-Based Anticancer Complexes and p53
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  • Release Date: 2023-06-02
  • p53 family
  • zinc
  • copper
  • iron
  • ruthenium
  • platinum
  • metal anticancer complexes
  • bioinorganic
Video Introduction

This video is adapted from 10.3390/cancers15102834

P53 plays a key role in protecting the human genome from DNA-related mutations; however, it is one of the most frequently mutated genes in cancer. The P53 family members p63 and p73 were also shown to play important roles in cancer development and progression. There are various organic molecules from different structural classes of compounds that could reactivate the function of wild-type p53, degrade or inhibit mutant p53, etc. It was shown that: (1) the function of the wild-type p53 protein was dependent on the presence of Zn atoms, and (2) Zn supplementation restored the altered conformation of the mutant p53 protein. This prompted us to question whether the dependence of p53 on Zn and other metals might be used as a cancer vulnerability.

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Babak, M.; Alfadul, S.M.; Matnurov, E.M.; Varakutin, A.E. Metal-Based Anticancer Complexes and p53. Encyclopedia. Available online: (accessed on 19 April 2024).
Babak M, Alfadul SM, Matnurov EM, Varakutin AE. Metal-Based Anticancer Complexes and p53. Encyclopedia. Available at: Accessed April 19, 2024.
Babak, Maria, Samah Mutasim Alfadul, Egor M. Matnurov, Alexander E. Varakutin. "Metal-Based Anticancer Complexes and p53" Encyclopedia, (accessed April 19, 2024).
Babak, M., Alfadul, S.M., Matnurov, E.M., & Varakutin, A.E. (2023, June 02). Metal-Based Anticancer Complexes and p53. In Encyclopedia.
Babak, Maria, et al. "Metal-Based Anticancer Complexes and p53." Encyclopedia. Web. 02 June, 2023.