Novel Molecular Profile in Malignant Insulinoma
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  • Release Date: 2023-04-03
  • hyperinsulinemic hypoglycemia
  • malignant insulinoma
  • pancreatic neuroendocrine tumor
  • somatostatin receptor
  • 68 Gallium DOTATATE PET/CT
  • molecular imaging
  • molecular profile of pNET
Video Introduction

This video is adapted from 10.3390/jcm12041280

There will be a brief case presentation highlighting the clinical features of a malignant insulinoma representing a very rare functional pancreatic neuroendocrine tumor (pNET). The relevant diagnostic biochemical, imaging, and immunohistochemical features will be presented. The video will point out the specific epidemiological characteristics of malignant insulinomas including treatment options and prognostic factors. Particular emphasis will be focusing on the role of somatostatin receptors in theranostics of pNETs and the mutational profiling of NETs originating from various anatomical locations. The novel molecular findings in this case will be stated and put into context of the current molecular landscape of pNETs with potential novel treatment targets. 

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Weber, C.; Burns, L.; Naimi, B.; Ronan, M.; Xu, H. Novel Molecular Profile in Malignant Insulinoma. Encyclopedia. Available online: (accessed on 15 April 2024).
Weber C, Burns L, Naimi B, Ronan M, Xu H. Novel Molecular Profile in Malignant Insulinoma. Encyclopedia. Available at: Accessed April 15, 2024.
Weber, Christian, Laura Burns, Bita Naimi, Matthew Ronan, Huihong Xu. "Novel Molecular Profile in Malignant Insulinoma" Encyclopedia, (accessed April 15, 2024).
Weber, C., Burns, L., Naimi, B., Ronan, M., & Xu, H. (2023, April 03). Novel Molecular Profile in Malignant Insulinoma. In Encyclopedia.
Weber, Christian, et al. "Novel Molecular Profile in Malignant Insulinoma." Encyclopedia. Web. 03 April, 2023.