Gold Nanoparticles as Drug Carriers
  • View Times: 21
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  • Release Date: 2023-04-01
  • nanomedicine
  • nanoparticle
  • nanoparticle synthesis
  • gold nanoparticle
  • drug delivery
  • drug carrier
  • polyethylene glycol
  • silica
  • nanocarrier
  • ibuprofen
Video Introduction

This video is adapted from 10.3390/mi14020451

The use of gold nanoparticles as drug delivery systems has received increasing attention due to their unique properties, such as their high stability and biocompatibility. [1][2][3] However, gold nanoparticles have a high affinity for proteins, which can result in their rapid clearance from the body and limited drug loading capabilities. To address these limitations, researchers coated the gold nanoparticles with silica and PEG, which are known to improve the stability of nanoparticles. The synthesis of the nanoparticles was carried out using a reduction method. The nanoparticles’ size, morphology, and drug loading capacity were also studied. The SEM images showed a spherical and homogeneous morphology; they also showed that the coatings increased the average size of the nanoparticles.

References
  1. Carreón González, José Luis; García Casillas, Perla Elvia; Chapa González, Christian; Gold Nanoparticles as Drug Carriers: The Role of Silica and PEG as Surface Coatings in Optimizing Drug Loading. Micromachines 2023, 14(2), 451, 10.3390/mi14020451.
  2. Arellano Ramírez, Susana Helena; García Casillas, Perla Elvia; Chapa González Christian; Seed-mediated synthesis and PEG coating of gold nanoparticles for controlling morphology and sizes. MRS Advances 2020, 5, 3353–3360, 10.1557/adv.2020.416.
  3. Carreón González, José Luis; García Casillas, Perla Elvia; Chapa González, Christian; Drug loading in gold nanoparticles. Zenodo 2022, 1, https://zenodo.org/record/7451868, 10.5281/zenodo.7451868.
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Chapa, C.; González, J.L.C.; Casillas, P.E.G. Gold Nanoparticles as Drug Carriers. Encyclopedia. Available online: https://encyclopedia.pub/video/video_detail/677 (accessed on 15 April 2024).
Chapa C, González JLC, Casillas PEG. Gold Nanoparticles as Drug Carriers. Encyclopedia. Available at: https://encyclopedia.pub/video/video_detail/677. Accessed April 15, 2024.
Chapa, Christian, José Luis Carreón González, Perla Elvia García Casillas. "Gold Nanoparticles as Drug Carriers" Encyclopedia, https://encyclopedia.pub/video/video_detail/677 (accessed April 15, 2024).
Chapa, C., González, J.L.C., & Casillas, P.E.G. (2023, April 01). Gold Nanoparticles as Drug Carriers. In Encyclopedia. https://encyclopedia.pub/video/video_detail/677
Chapa, Christian, et al. "Gold Nanoparticles as Drug Carriers." Encyclopedia. Web. 01 April, 2023.