Electrospun Shellac Fibers Loaded with Kaempferia parviflora Extract
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  • Release Date: 2023-03-24
  • electrospun fiber
  • shellac
  • Kaempferia parviflora
  • Box–Behnken design
  • dissolution
  • methoxyflavones
  • antibacterial activity
Video Introduction

This video is adapted from 10.3390/pharmaceutics15010123

Kaempferia parviflora (KP), also known as Kra-Chai-Dam, is frequently used in traditional medicine to treat inflammation, swelling, wounds, bacterial infection, ringworm, and a variety of other disorders. The biological activities of its rhizomes including antimicrobial, antifungal, antioxidant, and anti-inflammatory activities. This study aimed to develop a KP extract based on electrospun shellac fibers capable of transporting methoxyflavones. This study used a Box–Behnken design to determine the optimal production parameters that influence the fiber diameter and bead-to-fiber ratio responses. The optimization step produced fibers with a small diameter (574 nm) and a lower bead-to-fiber ratio (0.48 beads per fiber) by combining 37.25% w/w shellac and 1.50% w/w KP extract with a solution feed rate of 0.8 mL/h and an electrical voltage of 18 kV. The KP extract was found to be dispersed throughout the electrospun shellac fibers during the characterization study. The results were highly correlated with the theoretical values, indicating that the regression models used to predict the response variables were adequate. A study of in vitro dissolution confirmed that KP extract-loaded electrospun shellac fibers could produce a sustained-release profile within 10 h. Additionally, KP-infused shellac fibers demonstrated antibacterial activity against Staphylococcus aureus. This KP loading method combined with shellac properties provided a new delivery system and could be used to explore novel biomedical materials.

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Limmatvapirat, C.; Krongrawa, W.; Limmatvapirat, S.; Vollrath, M.K.; Kittakoop, P.; Saibua, S. Electrospun Shellac Fibers Loaded with Kaempferia parviflora Extract. Encyclopedia. Available online: https://encyclopedia.pub/video/video_detail/662 (accessed on 15 April 2024).
Limmatvapirat C, Krongrawa W, Limmatvapirat S, Vollrath MK, Kittakoop P, Saibua S. Electrospun Shellac Fibers Loaded with Kaempferia parviflora Extract. Encyclopedia. Available at: https://encyclopedia.pub/video/video_detail/662. Accessed April 15, 2024.
Limmatvapirat, Chutima, Wantanwa Krongrawa, Sontaya Limmatvapirat, Mont Kumpugdee Vollrath, Prasat Kittakoop, Supachai Saibua. "Electrospun Shellac Fibers Loaded with Kaempferia parviflora Extract" Encyclopedia, https://encyclopedia.pub/video/video_detail/662 (accessed April 15, 2024).
Limmatvapirat, C., Krongrawa, W., Limmatvapirat, S., Vollrath, M.K., Kittakoop, P., & Saibua, S. (2023, March 24). Electrospun Shellac Fibers Loaded with Kaempferia parviflora Extract. In Encyclopedia. https://encyclopedia.pub/video/video_detail/662
Limmatvapirat, Chutima, et al. "Electrospun Shellac Fibers Loaded with Kaempferia parviflora Extract." Encyclopedia. Web. 24 March, 2023.