Neutrophils Activated by PMA (Phorbol Myristate Acetate)
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  • Release Date: 2022-10-13
  • neutrophil
  • PMA
  • NETs
  • PAD4
  • neutrophil extracellular trap
Video Introduction

This video is adapted from 10.3390/cells11182889

Neutrophils are the first cells to migrate to an inflammation site. They fight against pathogens using phagocytosis, reactive oxygen species (ROS), enzymes and DNA release in neutrophil extracellular traps (NETs).
It is through pattern recognition receptors (PRRs) that neutrophils recognize molecular structures such as pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs) and start the activation process. Neutrophil activation and recruitment are regulated by pro-inflammatory cytokines, endothelial cells, platelet activation factor (PAF), and microbial products, among other substances, but that is not the case for PMA.
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Fontes, W.; Damascena, H.;  Silveira, W.A.;  Castro, M.S. Neutrophils Activated by PMA (Phorbol Myristate Acetate). Encyclopedia. Available online: (accessed on 26 September 2023).
Fontes W, Damascena H,  Silveira WA,  Castro MS. Neutrophils Activated by PMA (Phorbol Myristate Acetate). Encyclopedia. Available at: Accessed September 26, 2023.
Fontes, Wagner, Hylane Damascena, Wendy Assis Silveira, Mariana S. Castro. "Neutrophils Activated by PMA (Phorbol Myristate Acetate)" Encyclopedia, (accessed September 26, 2023).
Fontes, W., Damascena, H.,  Silveira, W.A., & Castro, M.S.(2022, October 13). Neutrophils Activated by PMA (Phorbol Myristate Acetate). In Encyclopedia.
Fontes, Wagner, et al. "Neutrophils Activated by PMA (Phorbol Myristate Acetate)." Encyclopedia. Web. 13 October, 2022.