Breast Cancer during Pregnancy
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  • Release Date: 2022-09-02
  • breast cancer during pregnancy
  • early-onset breast cancer
  • pregnancy-related breast cancer
Video Introduction

This video is adapted from 10.3390/cells11152286

Breast cancer during pregnancy (PrBC) is a rare tumor with only a little information on its immune landscape. Researchers sought to characterize the cellular composition of the tumor microenvironment (TME) of PrBC and identify its differences from early-onset breast cancer (EOBC) in non-pregnant women. A total of 83 PrBC and 89 EOBC were selected from our Institutional registry and subjected to tumor-infiltrating lymphocytes (TILs) profiling and immunohistochemistry for CD4, CD8, forkhead box P3 (FOXP3), and programmed death-ligand 1 (PD-L1) (clone 22C3). A significantly lower frequency of hormone receptor (HR)-positive tumors was observed in PrBC. The prevalence of low/null PD-L1 and CD8+TILs was higher in PrBC than in the controls, specifically in HR+/HER2– breast cancers. PrBC had a significantly higher risk of relapse and disease-related death, compared to EOBC. The presence of TILs and each TIL subpopulation were significantly associated with disease relapse. Moreover, the death rate was higher in PrBC with CD8+ TILs. The TME of PrBC is characterized by specific patterns of TIL subpopulations with significant biological and prognostic roles. Routine assessment of TILs and TILs subtyping in these patients would be a valid addition to the pathology report that might help identify clinically relevant subsets of women with PrBC.

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Sajjadi, E.;  Venetis, K.;  Noale, M.;  Jr, H.A.A.;  Blundo, C.;  Bonizzi, G.;  Loreto, E.D.;  Scarfone, G.;  Ferrero, S.;  Maggi, S.; et al. Breast Cancer during Pregnancy. Encyclopedia. Available online: (accessed on 24 April 2024).
Sajjadi E,  Venetis K,  Noale M,  Jr HAA,  Blundo C,  Bonizzi G, et al. Breast Cancer during Pregnancy. Encyclopedia. Available at: Accessed April 24, 2024.
Sajjadi, Elham, Konstantinos Venetis, Marianna Noale, Hatem A Azim Jr, Concetta Blundo, Giuseppina Bonizzi, Eugenia Di Loreto, Giovanna Scarfone, Stefano Ferrero, Stefania Maggi, et al. "Breast Cancer during Pregnancy" Encyclopedia, (accessed April 24, 2024).
Sajjadi, E.,  Venetis, K.,  Noale, M.,  Jr, H.A.A.,  Blundo, C.,  Bonizzi, G.,  Loreto, E.D.,  Scarfone, G.,  Ferrero, S.,  Maggi, S.,  Barberis, M.,  Veronesi, P.,  Galimbreti, V.,  Viale, G.,  Fusco, N.,  Peccatori, F.A., & Guerini-Rocco, E. (2022, September 02). Breast Cancer during Pregnancy. In Encyclopedia.
Sajjadi, Elham, et al. "Breast Cancer during Pregnancy." Encyclopedia. Web. 02 September, 2022.