Impaired Folate-Mediated One-Carbon Metabolism
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  • Release Date: 2022-03-16
  • Alzheimer’s disease
  • COVID-19
  • epigenetics
  • homocysteine
  • Long COVID
  • MTHFR gene mutations
  • nutritional B vitamin deficiencies
  • PASC
Video Introduction

This video is adapted from 10.3390/medicina58010016

Impaired folate-mediated one-carbon metabolism (FOCM) is associated with many pathologies and developmental abnormalities. FOCM is a metabolic network of interdependent biosynthetic pathways that is known to be compartmentalized in the cytoplasm, mitochondria and nucleus. Currently, the biochemical mechanisms and causal metabolic pathways responsible for the initiation and/or progression of folate-associated pathologies have yet to be fully established.

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Hayden, M. Impaired Folate-Mediated One-Carbon Metabolism. Encyclopedia. Available online: (accessed on 13 April 2024).
Hayden M. Impaired Folate-Mediated One-Carbon Metabolism. Encyclopedia. Available at: Accessed April 13, 2024.
Hayden, Melvin . "Impaired Folate-Mediated One-Carbon Metabolism" Encyclopedia, (accessed April 13, 2024).
Hayden, M. (2022, March 16). Impaired Folate-Mediated One-Carbon Metabolism. In Encyclopedia.
Hayden, Melvin . "Impaired Folate-Mediated One-Carbon Metabolism." Encyclopedia. Web. 16 March, 2022.