Exploring Acceptability Drivers of Oral Antibiotics in Children
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  • Release Date: 27 Jan 2022
  • acceptability
  • antibiotic
  • formulation
  • pediatric
  • children
  • ClinSearch acceptability score test (CAST)
Video Introduction

This video is adapted from 10.3390/pharmaceutics13101721

Antibiotics are among the most commonly prescribed drugs in children. Adherence to the treatment with these drugs is of the utmost importance to prevent the emergence of resistant bacteria, a global health threat. In children, medicine acceptability is likely to have a significant impact on compliance. Herein we used a multivariate approach, considering simultaneously the many aspects of acceptability to explore the drivers of oral antibiotic acceptability in children under twelve, especially in toddlers and in preschoolers. Based on 628 real-life observer reports of the intake of 133 distinct medicines, the acceptability reference framework highlighted the influence of many factors such as age and sex of patients, previous exposure to treatment, place of administration, administration device, flavor agent in excipients and active pharmaceutical ingredient. These findings from an international observational study emphasize the multidimensional nature of acceptability. Therefore, it is crucial to consider all these different aspects for assessing this multi-faceted concept and designing or prescribing a medicine in order to reach adequate acceptability in the target population.

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Vallet, T.; Saito, J.; Mathiesen, L.; Klingmann, V.; Peak, M.; Elhamdaoui, O.; Yamatani, A.; Ivanovic, I.; Bracken, L.; Duncan, J.; et al. Exploring Acceptability Drivers of Oral Antibiotics in Children. Encyclopedia. Available online: https://encyclopedia.pub/video/video_detail/186 (accessed on 23 February 2024).
Vallet T, Saito J, Mathiesen L, Klingmann V, Peak M, Elhamdaoui O, et al. Exploring Acceptability Drivers of Oral Antibiotics in Children. Encyclopedia. Available at: https://encyclopedia.pub/video/video_detail/186. Accessed February 23, 2024.
Vallet, Thibault, Jumpei Saito, Liv Mathiesen, Viviane Klingmann, Matthew Peak, Omar Elhamdaoui, Akimasa Yamatani, Ivana Ivanovic, Louise Bracken, Jennifer Duncan, et al. "Exploring Acceptability Drivers of Oral Antibiotics in Children" Encyclopedia, https://encyclopedia.pub/video/video_detail/186 (accessed February 23, 2024).
Vallet, T., Saito, J., Mathiesen, L., Klingmann, V., Peak, M., Elhamdaoui, O., Yamatani, A., Ivanovic, I., Bracken, L., Duncan, J., Salunke, S., & Ruiz, F. (2022, January 27). Exploring Acceptability Drivers of Oral Antibiotics in Children. In Encyclopedia. https://encyclopedia.pub/video/video_detail/186
Vallet, Thibault, et al. "Exploring Acceptability Drivers of Oral Antibiotics in Children." Encyclopedia. Web. 27 January, 2022.