Heat-Shock Protein B1
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  • Release Date: 2022-01-21
  • heat-shock proteins
  • diabetes mellitus
  • beta-cells
  • endoplasmic reticulum stress
  • HSPB1
  • beta-cell transplantation
  • prolactin
Video Introduction

This video is adapted from 10.3390/cells10092178

During type 1 diabetes mellitus (T1DM) development, beta-cells undergo intense endoplasmic reticulum (ER) stress that could result in apoptosis through the failure of adaptation to the unfolded protein response (UPR). Islet transplantation is considered an attractive alternative among beta-cell replacement therapies for T1DM. To avoid the loss of beta-cells that will jeopardize the transplant’s outcome, several strategies are being studied.

Researchers have previously shown that  prolactin induces protection against pro-inflammatory cytokines and redox imbalance-induced beta-cell death by increasing heat shock protein B1 (HSPB1) levels.

Since the role of HSPB1 in beta  cells has not been deeply studied, researchers investigated the mechanisms involved in unbalanced protein homeostasis caused by intense ER stress and overload of the proteasomal protein degradation  pathway. Researchers tested whether HSPB1-mediated cytoprotective effects involved UPR modulation  and improvement of protein degradation via the ubiquitin-proteasome system.

They demonstrated  that increased levels of HSPB1: attenuated levels of pro-apoptotic proteins like CHOP and BIM,  increased protein ubiquitination and the speed of proteasomal protein degradation. Their data  showed that HSPB1 induced resistance to proteotoxic stress and thus enhanced cell survival via an  increase in beta-cell proteolytic capacity. These results could contribute to generate strategies  aiming at optimization of beta-cell replacement therapies.

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Labriola, L.; Gomes, V.D.M.; Wailemann Mansano, R.A.; Dos Santos, A.; Lortz, S. Heat-Shock Protein B1. Encyclopedia. Available online: https://encyclopedia.pub/video/video_detail/183 (accessed on 21 May 2024).
Labriola L, Gomes VDM, Wailemann Mansano RA, Dos Santos A, Lortz S. Heat-Shock Protein B1. Encyclopedia. Available at: https://encyclopedia.pub/video/video_detail/183. Accessed May 21, 2024.
Labriola, Leticia, Vinicius De Morais Gomes, Rosangela A Wailemann Mansano, Ancely Dos Santos, Stephan Lortz. "Heat-Shock Protein B1" Encyclopedia, https://encyclopedia.pub/video/video_detail/183 (accessed May 21, 2024).
Labriola, L., Gomes, V.D.M., Wailemann Mansano, R.A., Dos Santos, A., & Lortz, S. (2022, January 21). Heat-Shock Protein B1. In Encyclopedia. https://encyclopedia.pub/video/video_detail/183
Labriola, Leticia, et al. "Heat-Shock Protein B1." Encyclopedia. Web. 21 January, 2022.
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