• Weight Pulling
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  • Release time: 2021-12-15
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  • skeletal muscle
  • hypertrophy
  • myonuclear accretion
  • protein synthesis
Video Introduction

This entry describes a mouse model of progressive resistance exercise that utilizes a full-body/multi-joint exercise (weight pulling) along with a training protocol that mimics a traditional human paradigm (three training sessions per week, ~8–12 repetitions per set, 2 min of rest between sets, approximately two maximal-intensity sets per session, last set taken to failure, and a progressive increase in loading that is based on the individual’s performance). Author demonstrates weight pulling can induce an increase in the mass of numerous muscles throughout the body. The relative increase in muscle mass is similar to what has been observed in human studies, and is associated with the same type of long-term adaptations that occur in humans (e.g., fiber hypertrophy, myonuclear accretion, and, in some instances, a fast-to-slow transition in Type II fiber composition). Moreover, author demonstrates that weight pulling can induce the same type of acute responses that are thought to drive these long-term adaptations (e.g., the activation of signaling through mTORC1 and the induction of protein synthesis at 1 h post-exercise). Collectively, the results of this entry indicate that weight pulling can serve as a highly translatable mouse model of progressive resistance exercise.

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If you have any further questions, please contact Encyclopedia Editorial Office.
Hornberger, T. Weight Pulling. Encyclopedia. Available online: https://encyclopedia.pub/video/video_detail/143 (accessed on 25 June 2022).
Hornberger T. Weight Pulling. Encyclopedia. Available at: https://encyclopedia.pub/video/video_detail/143. Accessed June 25, 2022.
Hornberger, Troy. "Weight Pulling," Encyclopedia, https://encyclopedia.pub/video/video_detail/143 (accessed June 25, 2022).
Hornberger, T. (2021, December 15). Weight Pulling. In Encyclopedia. https://encyclopedia.pub/video/video_detail/143
Hornberger, Troy. ''Weight Pulling.'' Encyclopedia. Web. 15 December, 2021.
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