• Cardiovascular Signal Entropy and Cognitive Performance
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  • Release time: 2021-12-13
  • sample entropy
  • cognition
  • cognitive decline
  • cardiovascular
  • blood pressure
Video Introduction

In this study, the relationship between non-invasively measured cardiovascular signal entropy and global cognitive performance was explored in a sample of community-dwelling older adults from The Irish Longitudinal Study on Ageing (TILDA), both cross-sectionally at baseline (n = 4525; mean (SD) age: 61.9 (8.4) years; 54.1% female) and longitudinally. We hypothesised that signal disorder in the cardiovascular system, as quantified by short-length signal entropy during rest, could provide a marker for cognitive function. Global cognitive function was assessed via Mini Mental State Examination (MMSE) across five longitudinal waves (8 year period; n = 4316; mean (SD) age: 61.9 (8.4) years; 54.4% female) and the Montreal Cognitive Assessment (MOCA) across two longitudinal waves (4 year period; n = 3600; mean (SD) age: 61.7 (8.2) years; 54.1% female). Blood pressure (BP) was continuously monitored during supine rest at baseline, and sample entropy values were calculated for one-minute and five-minute sections of this data, both for time-series data interpolated at 5 Hz and beat-to-beat data. Results revealed significant associations between BP signal entropy and cognitive performance, both cross-sectionally and longitudinally. Results also suggested that as regards associations with cognitive performance, the entropy analysis approach used herein potentially outperformed more traditional cardiovascular measures such as resting heart rate and heart rate variability. The quantification of entropy in short-length BP signals could provide a clinically useful marker of the cardiovascular dysregulations that potentially underlie cognitive decline.

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Knight, S.; Newman, L.; O'connor, J.; Davis, J.R.; Romero-Ortuno, R. Cardiovascular Signal Entropy and Cognitive Performance. Encyclopedia. Available online: https://encyclopedia.pub/video/video_detail/135 (accessed on 27 June 2022).
Knight S, Newman L, O'connor J, Davis JR, Romero-Ortuno R. Cardiovascular Signal Entropy and Cognitive Performance. Encyclopedia. Available at: https://encyclopedia.pub/video/video_detail/135. Accessed June 27, 2022.
Knight, Silvin, Louise Newman, John O'connor, James R.c. Davis, Roman Romero-Ortuno. "Cardiovascular Signal Entropy and Cognitive Performance," Encyclopedia, https://encyclopedia.pub/video/video_detail/135 (accessed June 27, 2022).
Knight, S., Newman, L., O'connor, J., Davis, J.R., & Romero-Ortuno, R. (2021, December 13). Cardiovascular Signal Entropy and Cognitive Performance. In Encyclopedia. https://encyclopedia.pub/video/video_detail/135
Knight, Silvin, et al. ''Cardiovascular Signal Entropy and Cognitive Performance.'' Encyclopedia. Web. 13 December, 2021.