Firmicutes/Bacteroidetes Ratio as a Risk Factor of Breast Cancer
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  • Release Date: 2024-08-27
  • Firmicutes/Bacteroides ratio
  • breast cancer
  • microbiome
Video Introduction

This video is adapted from 10.3390/jcm12062216

The gut microbiome can reflect the health condition of the entire body. Firmicutes and Bacteroidetes, the major phyla of the colon, can influence diseases related to obesity which are also risk factors for breast cancer. Therefore, the Firmicutes/Bacteroidetes (F/B) ratio was analyzed in patients with breast cancer. Bacterial extracellular vesicles were extracted from the serum of patients with breast cancer and healthy controls. Phyla Firmicutes and Bacteroidetes were analyzed using microbiome sequencing. Prognostic factors for breast cancer and serological test results were analyzed for correlations with the F/B ratio. The F/B ratio was three times lower in patients with breast cancer than in healthy controls. In addition, the risk factor for breast cancer, such as fasting serum glucose, was found to be related to the F/B ratio. The F/B ratio can be used as a risk factor of breast cancer and as a clue to explain underlying mechanisms affecting the development of breast cancer. [1][2][3][4][5][6]

References
  1. Spase Stojanov; Aleš Berlec; Borut Štrukelj; The Influence of Probiotics on the Firmicutes/Bacteroidetes Ratio in the Treatment of Obesity and Inflammatory Bowel disease. Microorg. 2020, 8, 1715, .
  2. Laurence Zitvogel; Romain Daillère; María Paula Roberti; Bertrand Routy; Guido Kroemer; Anticancer effects of the microbiome and its products. Nat. Rev. Microbiol. 2017, 15, 465-478, .
  3. Natalia Vallianou; Gerasimos Socrates Christodoulatos; Irene Karampela; Dimitrios Tsilingiris; Faidon Magkos; Theodora Stratigou; Dimitris Kounatidis; Maria Dalamaga; Understanding the Role of the Gut Microbiome and Microbial Metabolites in Non-Alcoholic Fatty Liver Disease: Current Evidence and Perspectives. Biomol. 2021, 12, 56, .
  4. Chuan-Yin Fang; Jung-Sheng Chen; Bing-Mu Hsu; Bashir Hussain; Jagat Rathod; Kuo-Hsin Lee; Colorectal Cancer Stage-Specific Fecal Bacterial Community Fingerprinting of the Taiwanese Population and Underpinning of Potential Taxonomic Biomarkers. Microorg. 2021, 9, 1548, .
  5. David Rios-Covian; Borja Sánchez; Nuria Salazar; Noelia Martínez; Begoña Redruello; Miguel Gueimonde; Clara G. de Los Reyes-Gavilán; Different metabolic features of Bacteroides fragilis growing in the presence of glucose and exopolysaccharides of bifidobacteria. Front. Microbiol. 2015, 6, 825, .
  6. Chifei Kang; Derek LeRoith; Emily J Gallagher; Diabetes, Obesity, and Breast Cancer. Endocrinol. 2018, 159, 3801-3812, .
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An, J.; Kwon, H.; Kim, Y.J. Firmicutes/Bacteroidetes Ratio as a Risk Factor of Breast Cancer. Encyclopedia. Available online: https://encyclopedia.pub/video/video_detail/1345 (accessed on 01 September 2024).
An J, Kwon H, Kim YJ. Firmicutes/Bacteroidetes Ratio as a Risk Factor of Breast Cancer. Encyclopedia. Available at: https://encyclopedia.pub/video/video_detail/1345. Accessed September 01, 2024.
An, Jeongshin, Hyungju Kwon, Young Ju Kim. "Firmicutes/Bacteroidetes Ratio as a Risk Factor of Breast Cancer" Encyclopedia, https://encyclopedia.pub/video/video_detail/1345 (accessed September 01, 2024).
An, J., Kwon, H., & Kim, Y.J. (2024, August 27). Firmicutes/Bacteroidetes Ratio as a Risk Factor of Breast Cancer. In Encyclopedia. https://encyclopedia.pub/video/video_detail/1345
An, Jeongshin, et al. "Firmicutes/Bacteroidetes Ratio as a Risk Factor of Breast Cancer." Encyclopedia. Web. 27 August, 2024.
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