Role of Platelets in Virus-Induced Inflammatory Demyelinating Disease and Myocarditis
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  • Release Date: 2024-04-16
  • glycoprotein Ib α chain
  • bioinformatics analysis
  • RNA sequencing analyses
  • regulation of gene expression
  • dilated cardiomyopathy
  • neuroinflammatory disease
  • picornavirus infections
Video Introduction

This video is adapted from 10.3390/ijms25063460

Theiler’s murine encephalomyelitis virus (TMEV) infection has been used as a mouse model for two virus-induced organ-specific immune-mediated diseases. TMEV-induced demyelinating disease (TMEV-IDD) in the central nervous system (CNS) is a chronic inflammatory disease with viral persistence and an animal model of multiple sclerosis (MS) in humans. TMEV infection can also cause acute myocarditis with viral replication and immune cell infiltration in the heart, leading to cardiac fibrosis. Since platelets have been reported to modulate immune responses, researchers aimed to determine the role of platelets in TMEV infection. In transcriptome analyses of platelets, distinct sets of immune-related genes, including major histocompatibility complex (MHC) class I, were up- or downregulated in TMEV-infected mice at different time points. Researchers depleted platelets from TMEV-infected mice by injecting them with platelet-specific antibodies. The platelet-depleted mice had significantly fewer viral antigen-positive cells in the CNS. Platelet depletion reduced the severities of TMEV-IDD and myocarditis, although the pathology scores did not reach statistical significance. Immunologically, the platelet-depleted mice had an increase in interferon (IFN)-γ production with a higher anti-TMEV IgG2a/IgG1 ratio. Thus, platelets may play roles in TMEV infection, such as gene expression, viral clearance, and anti-viral antibody isotype responses.

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Ahmad, I.; Omura, S.; Sato, F.; Park, A.; Khadka, S.; Gavins, F.N.E.; Tanaka, H.; Kimura, M.Y.; Tsunoda, I. Role of Platelets in Virus-Induced Inflammatory Demyelinating Disease and Myocarditis. Encyclopedia. Available online: https://encyclopedia.pub/video/video_detail/1209 (accessed on 25 May 2024).
Ahmad I, Omura S, Sato F, Park A, Khadka S, Gavins FNE, et al. Role of Platelets in Virus-Induced Inflammatory Demyelinating Disease and Myocarditis. Encyclopedia. Available at: https://encyclopedia.pub/video/video_detail/1209. Accessed May 25, 2024.
Ahmad, Ijaz, Seiichi Omura, Fumitaka Sato, Ah-Mee Park, Sundar Khadka, Felicity N. E. Gavins, Hiroki Tanaka, Motoko Y. Kimura, Ikuo Tsunoda. "Role of Platelets in Virus-Induced Inflammatory Demyelinating Disease and Myocarditis" Encyclopedia, https://encyclopedia.pub/video/video_detail/1209 (accessed May 25, 2024).
Ahmad, I., Omura, S., Sato, F., Park, A., Khadka, S., Gavins, F.N.E., Tanaka, H., Kimura, M.Y., & Tsunoda, I. (2024, April 16). Role of Platelets in Virus-Induced Inflammatory Demyelinating Disease and Myocarditis. In Encyclopedia. https://encyclopedia.pub/video/video_detail/1209
Ahmad, Ijaz, et al. "Role of Platelets in Virus-Induced Inflammatory Demyelinating Disease and Myocarditis." Encyclopedia. Web. 16 April, 2024.
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