This video examines how the aging of the population and the prevalence of dementia make understanding the disease and its impact on spouses and partners a pertinent public health issue. It highlights that spousal caregivers are a crucial component of dementia care, with responsibilities that are complex and involve a major shift in roles, as well as the need to navigate new, ever-emerging challenges. This video notes that delivering care and providing emotional support strains the caregiver, with one significant challenge being a decline in the social network, especially when caregiving is intensive. Spouses of patients with dementia may experience loneliness, depression, and anxiety. While no single intervention is entirely sufficient in supporting caregivers, this video explains that effective mitigation strategies commonly employ an integrated, flexible approach that evolves in parallel to the caregiving trajectory. It emphasizes that the spousal caregiver subgroup requires focused research to better understand the implications of their unique caregiving situation. The primary aim of this video is to synthesize and critically interpret the existing literature examining the biopsychosocial health consequences of dementia caregiving on spousal caregivers, with particular emphasis on physiological stress pathways, mental health morbidity, and risk for long-term physical and cognitive decline.