Porcine reproductive and respiratory syndrome (PRRS) is a significant infectious disease threatening swine production. In China, emerging NADC30-like PRRSV strains exhibit concerning features including frequent recombination events and partial immune evasion capabilities. In this study, we isolated and characterized a novel recombinant NADC30-like PRRSV strain, designated GZ2022, from a swine farm in Guizhou Province. The biological and pathogenic properties of this strain were systematically evaluated. Phylogenetic and recombination analyses revealed that GZ2022 is a recombinant virus, with NADC30 serving as the major parental strain and HuN4 as the minor contributor. In vivo experiments demonstrated that GZ2022 exhibits moderate virulence, inducing typical PRRS clinical signs in piglets, but causes less severe symptoms than highly pathogenic strains. These findings provide important insights into the molecular epidemiology and pathogenicity of PRRSV in China.