Mango (Mangifera indica L.) Leaves: Comparison
Please note this is a comparison between Version 2 by Camila Xu and Version 1 by Surinder Singh.

Mango (Mangifera indica L.) ascribed to the family Anacardiaceae has been adjudged as the vital traditionally significant and one of the most economically important tropical fruit crop globally.

  • mango leaves
  • biological activities
  • phenolic bioactives
  • polysaccharides
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References

  1. Barreto, J.C.; Trevisan, M.T.S.; Hull, W.E.; Erben, G.; De Brito, E.S.; Pfundstein, B.; Würtele, G.; Spiegelhalder, B.; Owen, R.W. Characterization and Quantitation of Polyphenolic Compounds in Bark, Kernel, Leaves, and Peel of Mango (Mangifera indica L.). J. Agric. Food Chem. 2008, 56, 5599–5610.
  2. Shah, K.A.; Patel, M.B.; Patel, R.J.; Parmar, P.K. Mangifera indica (Mango). Pharmacogn. Rev. 2010, 4, 42–48.
  3. Kulkarni, V.M.; Rathod, V.K. Extraction of mangiferin from Mangifera indica leaves using three phase partitioning coupled with ultrasound. Ind. Crop. Prod. 2014, 52, 292–297.
  4. Ribeiro, S.M.R.; Schieber, A. Bioactive Compounds in Mango (Mangifera indica L.). In Bioactive Foods in Promoting Health; Elsevier BV: Oxford, UK, 2010; pp. 507–523.
  5. Lauricella, M.; Emanuele, S.; Calvaruso, G.; Giuliano, M.; D’Anneo, A. Multifaceted Health Benefits of Mangifera indica L. (Mango): The Inestimable Value of Orchards Recently Planted in Sicilian Rural Areas. Nutrients 2017, 9, 525.
  6. Masud Parvez, G.M. Pharmacological activities of mango (Mangifera indica): A review. J. Pharmacogn. Phytochem. 2016, 5, 1–7.
  7. Kabir, Y.; Shekhar, H.U.; Sidhu, J.S. Phytochemical Compounds in Functional Properties of Mangoes. In Handbook of Mango Fruit; Wiley: Hoboken, NJ, USA, 2017; pp. 237–254.
  8. Ediriweera, M.K.; Tennekoon, K.H.; Samarakoon, S.R. A Review on Ethnopharmacological Applications, Pharmacological Activities, and Bioactive Compounds of Mangifera indica (Mango). Evid. Based Complement. Altern. Med. 2017, 2017, 1–24.
  9. Batool, N.; Ilyas, N.; Shabir, S.; Saeed, M.; Mazhar, R. Mini-Review- A mini-review of therapeutic potential of Mangifera indica L. Pak. J. Pharm. Sci. 2018, 31, 1441–1448.
  10. Alberts, B.; Johnson, A.; Lewis, J.; Raff, M.; Roberts, K.; Walter, P. Protein Function. In Molecular Biology of the Cell; Garland Science: New York, NY, USA, 2002.
  11. Fafiolu, A.; Odugunawa, O.; Bambose, A.; Oso, A.; Isah, O.; Olantanji, J.; Jegede, A. Feeding value mango leaf (Mangifera indica) for growing rabbits. J. Anim. Vet. Adv. 2006, 5, 800–804.
  12. Akbar, M.; Alam, M. Effects of feeding mango (Mangifera indica) and shaora (Streblus asper) tree leaves to Black Bengal goats of Bangladesh. Small Rumin. Res. 1991, 6, 25–30.
  13. Laulloo, S.J.; Bhowon, M.G.; Soyfoo, S.; Chua, L.S. Nutritional and Biological Evaluation of Leaves of Mangifera indica from Mauritius. J. Chem. 2018, 2018, 1–9.
  14. Dayal, V.; Dubey, A.; Singh, S.; Sharma, R.; Dahuja, A.; Kaur, C. Growth, yield and physiology of mango (Mangifera indica L.) cultivars as affected by polyembryonic rootstocks. Sci. Hortic. 2016, 199, 186–197.
  15. Wetungu, M.; Tarus, P.; Segor, F.; Cheseto, X.; Omolo, M. Essential oil chemistry of some Mangifera indica varieties from Kenya. Am. J. Essent. Oils Nat. Prod. 2015, 3, 1–6.
  16. D[Zbreve]Amić, A.M.; Marin, P.D.; Gbolade, A.A.; Ristić, M.S. Chemical Composition of Mangifera indica Essential Oil from Nigeria. J. Essent. Oil Res. 2010, 22, 123–125.
  17. Fontenelle, R.O.D.S.; Sobrinho, A.C.N.; Soares, B.V.; De Aguiar, F.L.L.; De Brito, E.H.S.; Cavalcante, C.S.D.P.; Rocha, M.F.G.; De Morais, S.M. Effect of essential oils from Mangifera indica L. cultivars on the antifungal susceptibility of Candida spp. strains isolated from dogs. Rev. Bras. Saúde Produção Anim. 2017, 18, 337–346.
  18. Ouf, S.A.; Galal, A.M.F.; Ibrahim, H.S.; Hassan, A.Z.; Mekhael, M.K.G.; El-Yasergy, K.F.; El-Ghany, M.N.A.; Rizk, M.A.; Hanna, A.G. Phytochemical and antimicrobial investigation of the leaves of five Egyptian mango cultivars and evaluation of their essential oils as preservatives materials. J. Food Sci. Technol. 2020, 1–13.
  19. Gebara, S.S.; Ferreira, W.D.O.; Ré-Poppi, N.; Simionatto, E.; Carasek, E. Volatile compounds of leaves and fruits of Mangifera indica var. coquinho (Anacardiaceae) obtained using solid phase microextraction and hydrodistillation. Food Chem. 2011, 127, 689–693.
  20. Ali, B.A.; Alfa, A.A.; Tijani, K.B.; Idris, E.T.; Unoyiza, U.S.; Junaidu, Y. Nutritional Health Benefits and Bioactive Compounds of Mangifera indica L (Mango) Leaves Methanolic Extracts. Asian Plant Res. J. 2020, 6, 41–51.
  21. Princwill-Ogbonna, I.; Ogbonna, P.; Ogujiofor, I. Proximate Composition, Vitamin, Mineral and biologically Active Compounds Levels in Leaves of Mangifera indica (Mango), Persea americana (Avocado pea), and Annona muricata (Sour sop). J. Appl. Sci. Environ. Manag. 2019, 23, 65.
  22. Rymbai, H.; Srivastav, M.; Sharma, R.R.; Patel, C.R.; Singh, A.K. Bio-active compounds in mango (Mangifera indica L.) and their roles in human health and plant defence—A review. J. Hortic. Sci. Biotechnol. 2013, 88, 369–379.
  23. Abou-Awad, B.A.; Al-Azzazy, M.M.; Afia, S.I. Effect of the leaf coating miteCisaberoptus kenyaeKeifer (Acari: Eriophyidae) on the mineral content of the host mango plantMangiferae indicaL. Arch. Phytopathol. Plant Prot. 2012, 45, 16–21.
  24. Okwu, D.E.; Ezenagu, V.I.T.U.S. Evaluation of the phytochemical composition of mango (Mangifera indica Linn) stem bark and leaves. Int. J. Chem. Sci. 2008, 6, 705–716.
  25. Akram, M.; Munir, N.; Daniyal, M.; Egbuna, C.; Găman, M.-A.; Onyekere, P.F.; Olatunde, A. Vitamins and Minerals: Types, Sources and their Functions. In Functional Foods and Nutraceuticals; Springer International Publishing: New York, NY, USA, 2020; pp. 149–172.
  26. Zhang, Y.; Chen, Q.; Liu, M.-Y.; Ruan, J.-Y.; Yu, H.-Y.; Li, J.; Wang, T. Effects of Benzophenones from Mango Leaves on Lipid Metabolism. Chem. Pharm. Bull. 2019, 67, 634–639.
  27. Mirza, B.; Croley, C.R.; Ahmad, M.; Pumarol, J.; Das, N.; Sethi, G.; Bishayee, A. Mango (Mangifera indica L.): A magnificent plant with cancer preventive and anticancer therapeutic potential. Crit. Rev. Food Sci. Nutr. 2020, 1–27.
  28. Rasouli, H.; Farzaei, M.H.; Khodarahmi, R. Polyphenols and their benefits: A review. Int. J. Food Prop. 2017, 20, 1–42.
  29. Luca, S.V.; Macovei, I.; Bujor, A.; Miron, A.; Skalicka-Woźniak, K.; Aprotosoaie, A.C.; Trifan, A. Bioactivity of dietary polyphenols: The role of metabolites. Crit. Rev. Food Sci. Nutr. 2020, 60, 626–659.
  30. Pan, J.; Yi, X.; Zhang, S.; Cheng, J.; Wang, Y.; Liu, C.; He, X. Bioactive phenolics from mango leaves (Mangifera indica L.). Ind. Crop. Prod. 2018, 111, 400–406.
  31. Gu, C.; Yang, M.; Zhou, Z.; Khan, A.; Cao, J.; Cheng, G. Purification and characterization of four benzophenone derivatives from Mangifera indica L. leaves and their antioxidant, immunosuppressive and α-glucosidase inhibitory activities. J. Funct. Foods 2019, 52, 709–714.
  32. Martínez-Bernett, D.; Silva-Granados, A.; Correa-Torres, S.N.; Herrera, A. Chromatographic analysis of phytochemicals components present in Mangifera indica leaves for the synthesis of silver nanoparticles by AgNO3 reduction. J. Phys. Conf. Ser. 2016, 687, 12033.
  33. Ronchi, S.N.; Brasil, G.A.; Nascimento, A.M.D.; De Lima, E.M.; Scherer, R.; Costa, H.B.; Romão, W.; Boëchat, G.A.P.; Lenz, D.; Fronza, M.; et al. Phytochemical and in vitro and in vivo biological investigation on the antihypertensive activity of mango leaves (Mangifera indica L.). Ther. Adv. Cardiovasc. Dis. 2015, 9, 244–256.
  34. Swaroop, A.; Stohs, S.J.; Bagchi, M.; Moriyama, H.; Bagchi, D. Mango (Mangifera indica Linn) and Anti-Inflammatory Benefits: Versatile Roles in Mitochondrial Bio-Energetics and Exercise Physiology. Funct. Foods Heal. Dis. 2018, 8, 267.
  35. Jung, J.-S.; Jung, K.; Kim, N.-H.; Kim, H.-S. Selective inhibition of MMP-9 gene expression by mangiferin in PMA-stimulated human astroglioma cells: Involvement of PI3K/Akt and MAPK signaling pathways. Pharmacol. Res. 2012, 66, 95–103.
  36. Klein-Júnior, L.C.; Campos, A.; Niero, R.; Corrêa, R.; Heyden, Y.V.; Filho, V.C. Xanthones and Cancer: From Natural Sources to Mechanisms of Action. Chem. Biodivers. 2019, 17, e1900499.
  37. Li, H.; Huang, J.; Yang, B.; Xiang, T.; Yin, X.; Peng, W.; Cheng, W.; Wan, J.; Luo, F.; Li, H.; et al. Mangiferin exerts antitumor activity in breast cancer cells by regulating matrix metalloproteinases, epithelial to mesenchymal transition, and β-catenin signaling pathway. Toxicol. Appl. Pharmacol. 2013, 272, 180–190.
  38. Sakthisekaran, D.; Rajendran, P.; Rengarajan, T.; Nishigaki, I.; Ekambaram, G. Potent chemopreventive effect of mangiferin on lung carcinogenesis in experimental Swiss albino mice. J. Cancer Res. Ther. 2014, 10, 1033–1039.
  39. Zhang, B.-P.; Zhao, J.; Li, S.-S.; Yang, L.-J.; Zeng, L.-L.; Chen, Y.; Fang, J. Mangiferin activates Nrf2-antioxidant response element signaling without reducing the sensitivity to etoposide of human myeloid leukemia cells in vitro. Acta Pharmacol. Sin. 2013, 35, 257–266.
  40. Das, S.; Rao, B.N. Mangiferin attenuates methylmercury induced cytotoxicity against IMR-32, human neuroblastoma cells by the inhibition of oxidative stress and free radical scavenging potential. Chem. Interact. 2011, 193, 129–140.
  41. Fernández-Ponce, M.T.; López-Biedma, A.; Sánchez-Quesada, C.; Casas, L.; Mantell, C.; Gaforio, J.J.; De La Ossa, E.J.M. Selective antitumoural action of pressurized mango leaf extracts against minimally and highly invasive breast cancer. Food Funct. 2017, 8, 3610–3620.
  42. Palanuvej, C.; Ganogpichayagrai, A.; Ruangrungsi, N. Antidiabetic and anticancer activities of Mangifera indica cv. Okrong leaves. J. Adv. Pharm. Technol. Res. 2017, 8, 19–24.
  43. Anoop, N.V.; Jacob, R.; Paulson, J.M.; Dineshkumar, B.; Narayana, C.R. Mango leaf extract synthesized silver nanorods exert anticancer activity on breast cancer and colorectal carcinoma cells. J. Drug Deliv. Sci. Technol. 2018, 44, 8–12.
  44. Singab, A.N.; Youssef, F.S.; Ashour, M.L. Medicinal Plants with Potential Antidiabetic Activity and their Assessment. Med. Aromat. Plants 2014, 3, 151.
  45. Iid, I.I.; Kumar, S.; Shukla, S.; Kumar, V.; Sharma, R. Putative antidiabetic herbal food ingredients: Nutra/functional properties, bioavailability and effect on metabolic pathways. Trends Food Sci. Technol. 2020, 97, 317–340.
  46. Al-Malki, A.L.; El Rabey, H.A. The Antidiabetic Effect of Low Doses ofMoringa oleiferaLam. Seeds on Streptozotocin Induced Diabetes and Diabetic Nephropathy in Male Rats. BioMed Res. Int. 2015, 2015, 1–13.
  47. Nair, S.S.; Kavrekar, V.; Mishra, A. In vitro studies on alpha amylase and alpha glucosidase inhibitory activities of selected plant extracts. Eur. J. Exp. Biol. 2013, 3, 128–132.
  48. Kulkarni, V.M.; Rathod, V.K. Exploring the potential of Mangifera indica leaves extract versus mangiferin for therapeutic application. Agric. Nat. Resour. 2018, 52, 155–161.
  49. Saleem, M.; Tanvir, M.; Akhtar, M.F.; Iqbal, M.; Saleem, A. Antidiabetic Potential of Mangifera indica L. cv. Anwar Ratol Leaves: Medicinal Application of Food Wastes. Medicina 2019, 55, 353.
  50. Gupta, R. Active phytoconstituents for diabetes management: A review. J. Complement. Integr. Med. 2018, 15, 15.
  51. Islam, N.; Jung, H.A.; Sohn, H.S.; Kim, H.M.; Choi, J.S. Potent α-glucosidase and protein tyrosine phosphatase 1B inhibitors from Artemisia capillaris. Arch. Pharmacal Res. 2013, 36, 542–552.
  52. Bhuvaneshwari, J.; Khanam, S.; Devi, K. In-vitro enzyme inhibition studies for antidiabetic activity of mature and tender leaves of Mangifera indica var. Totapuri. Res. Rev. J. Microbiol. Biotechnol. 2014, 3, 36–41.
  53. Schraml, E.; Grillari, J. From cellular senescence to age-associated diseases: The miRNA connection. Longev. Health 2012, 1, 10.
  54. Kumar, Y.; Kumar, V. Sangeeta Comparative antioxidant capacity of plant leaves and herbs with their antioxidative potential in meat system under accelerated oxidation conditions. J. Food Meas. Charact. 2020, 14, 3250–3262.
  55. Wu, L.; Wu, W.; Cai, Y.; Li, C.; Wang, L. HPLC fingerprinting-based multivariate analysis of phenolic compounds in mango leaves varieties: Correlation to their antioxidant activity and in silico α-glucoidase inhibitory ability. J. Pharm. Biomed. Anal. 2020, 191, 113616.
  56. Itoh, K.; Matsukawa, T.; Okamoto, M.; Minami, K.; Tomohiro, N.; Shimizu, K.; Kajiyama, S.; Endo, Y.; Matsuda, H.; Shigeoka, S. In vitro Antioxidant Activity of Mangifera indica Leaf Extracts. J. Plant Stud. 2020, 9, 39.
  57. Mohan, C.G.; Deepak, M.; Viswanatha, G.L.; Savinay, G.; Hanumantharaju, V.; E Rajendra, C.; Halemani, P.D. Anti-oxidant and anti-inflammatory activity of leaf extracts and fractions of Mangifera indica. Asian Pac. J. Trop. Med. 2013, 6, 311–314.
  58. Kitbumrungsart, P.; Suntornwat, O.; Rayanil, K. Mangiferin and antioxidant capacity from mango (Mangifera indica L.) leaves extracts. Thai J. Agric. Sci. 2011, 44, 62–66.
  59. Prommajak, T.; Kim, S.M.; Pan, C.-H.; Kim, S.M.; Surawang, S.; Rattanapanone, N. Identification of Antioxidants in Young Mango Leaves by LC-ABTS and LC-MS. Chiang Mai Univ. J. Nat. Sci. 2014, 13, 317–330.
  60. Rambabu, K.; Bharath, G.; Banat, F.; Show, P.L.; Cocoletzi, H.H. Mango leaf extract incorporated chitosan antioxidant film for active food packaging. Int. J. Biol. Macromol. 2019, 126, 1234–1243.
  61. Park, A.; Ku, T.; Yoo, I. Antioxidant properties of fermented mango leaf extracts. J. Cosmet. Sci. 2015, 66, 1–13.
  62. Neuana, N.F.; Barboza, J.C.D.S.; Dos Santos, E.P.; Da Silva, M.L.C.P. A novel application of Mangifera indica L and Eugenia uniflora L extracts as antioxidants to control biodiesel oxidation stability. Environ. Prog. Sustain. Energy 2020.
  63. Dzotam, J.K.; Kuete, V. Antibacterial and Antibiotic-Modifying Activity of Methanol Extracts from Six Cameroonian Food Plants against Multidrug-Resistant Enteric Bacteria. BioMed Res. Int. 2017, 2017, 1–19.
  64. Bharti, R.P. Studies on antimicrobial activity and phytochemical profile of Mangifera indica leaf extract. IOSR J. Environ. Sci. Toxicol. Food Technol. 2013, 7, 74–78.
  65. Guo, L.; Gong, S.; Wang, Y.; Sun, Q.; Duo, K.; Fei, P. Antibacterial Activity of Olive Oil Polyphenol Extract Against Salmonella Typhimurium and Staphylococcus aureus: Possible Mechanisms. Foodborne Pathog. Dis. 2020, 17, 396–403.
  66. Islam, M.R.; Mannan, M.A.; Kabir, M.; Olival, K. Analgesic, anti-inflammatory and antimicrobial effects of ethanol extracts of mango leaves. J. Bangladesh Agric. Univ. 2010, 8, 239–244.
  67. Kanwal, Q.; Hussain, I.; Siddiqui, H.L.; Javaid, A. Antifungal activity of flavonoids isolated from mango (Mangifera indicaL.) leaves. Nat. Prod. Res. 2010, 24, 1907–1914.
  68. Konishi, K.; Adachi, H.; Ishigaki, N.; Kanamura, Y.; Adachi, I.; Tanaka, T.; Nishioka, I.; Nonaka, G.-I.; Horikoshi, I. Inhibitory Effects of Tannins on NADH Dehydrogenases of Various Organisms. Biol. Pharm. Bull. 1993, 16, 716–718.
  69. Hannan, A.; Asghar, S.; Naeem, T.; Ullah, M.I.; Ahmed, I.; Aneela, S.; Hussain, S. Antibacterial effect of mango (Mangifera indica Linn.) leaf extract against antibiotic sensitive and multi-drug resistant Salmonella typhi. Pak. J. Pharm. Sci. 2013, 26, 715–719.
  70. M, G.; U, V.N.; S, M.S.; R, A.K. Antimicrobial Activity of Some Medicinal Herbals. Int. J. Biotech Trends Technol. 2020, 10, 56–59.
  71. Pourahmad, J.; Eskandari, M.R.; Shakibaei, R.; Kamalinejad, M. A Search for Hepatoprotective Activity of Fruit Extract of Mangifera indica L. Against Oxidative Stress Cytotoxicity. Plant Foods Hum. Nutr. 2010, 65, 83–89.
  72. Ramírez, N.M.; Farias, L.M.; Santana, F.A.; Leite, J.P.V.; Dantas, M.I.D.S.; Toledo, R.C.L.; De Queiroz, J.H.; Martino, H.S.D.; Ribeiro, S.M.R. Extraction of Mangiferin and Chemical Characterization and Sensorial Analysis of Teas from Mangifera indica L. Leaves of the Ubá Variety. Beverages 2016, 2, 33.
  73. Peng, Y.; Rideout, D.; Rakita, S.; Sajan, M.; Farese, R.; You, M.; Murr, M.M. Downregulation of Adiponectin/AdipoR2 is Associated with Steatohepatitis in Obese Mice. J. Gastrointest. Surg. 2009, 13, 2043–2049.
  74. Ramírez, N.M.; De Queiróz, J.H.; Ribeiro, S.M.R.; Toledo, R.C.L.; Moreira, M.E.C.; Mafra, C.L.; Benjamin, L.D.A.; Coelho, C.D.M.; Veloso, M.P.; Martino, H.S.D. Mango leaf tea promotes hepatoprotective effects in obese rats. J. Funct. Foods 2018, 49, 437–446.
  75. Gururaja, G.M.; Mundkinajeddu, D.; Dethe, S.M.; Sangli, G.K.; Abhilash, K.; Agarwal, A. Cholesterol esterase inhibitory activity of bioactives from leaves of Mangifera indica L. Pharmacogn. Res. 2015, 7, 355–362.
  76. Ramírez, N.M.; Toledo, R.C.L.; Moreira, M.E.C.; Martino, H.S.D.; Benjamin, L.D.A.; De Queiroz, J.H.; Ribeiro, A.Q.; Ribeiro, S.M.R. Anti-obesity effects of tea from Mangifera indica L. leaves of the Ubá variety in high-fat diet-induced obese rats. Biomed. Pharmacother. 2017, 91, 938–945.
  77. Dethe, S.M.; Gururaja, G.M.; Mundkinajeddu, D.; Kumar, A.S.; Allan, J.J.; Agarwal, A. Evaluation of cholesterol-lowering activity of standardized extract of Mangifera indica in albino Wistar rats. Pharmacogn. Res. 2017, 9, 21–26.
  78. Sandoval-Gallegos, E.M.; Ramírez-Moreno, E.; De Lucio, J.G.; Arias-Rico, J.; Cruz-Cansino, N.; Ortiz, M.I.; Cariño-Cortés, R. In Vitro Bioaccessibility and Effect of Mangifera indica (Ataulfo) Leaf Extract on Induced Dyslipidemia. J. Med. Food 2018, 21, 47–56.
  79. Pan, J.; Yi, X.; Wang, Y.; Chen, G.; He, X. Benzophenones from Mango Leaves Exhibit α-Glucosidase and NO Inhibitory Activities. J. Agric. Food Chem. 2016, 64, 7475–7480.
  80. Sanchez-Sanchez, J.; Fernández-Ponce, M.; Casas, L.; Mantell, C.; De La Ossa, E.M. Impregnation of mango leaf extract into a polyester textile using supercritical carbon dioxide. J. Supercrit. Fluids 2017, 128, 208–217.
  81. Diso, S.U.; Ali, M.; Mukhtar, S.I.; Garba, M. Antibacterial Activity and Phytochemical Screening of Mangifera indica (Mango) Stem and Leaf Extracts on Clinical Isolates of Methicillin Resistant Staphylococcus aureus. J. Adv. Med. Pharm. Sci. 2017, 13, 1–6.
  82. Cardenas, V.; Mendoza, R.; Chiong, L.; Del Aguila, E. Comparison of the Antibacterial Activity of the Ethanol Extract vs Hydroalcoholic Extract of the Leaves of Mangifera indica L. (Mango) in Different Concentrations: An In Vitro Study. J. Contemp. Dent. Pract. 2020, 21, 202–206.
  83. Mustapha, A.A.; Enemali, M.O.; Olose, M.; Owuna, G.; Ogaji, J.O.; Idris, M.M.; Aboh, V.O.; Ogaji, O.; Idris, M. Phytoconstituents and Antibacterial efficacy of Mango (Mangifera indica) leave extracts. J. Med. Plants Stud. 2014, 2, 19–23.
  84. Oseghale, F.; Fasina, K.; Ohifueme, A.; Omoruyi, J. Biocontrol of Food Spoilage Microorganisms using Leaf extracts from Magnifera indica (Mango) and Psidium guajava (Guava). J. Chem. Soc. Niger. 2020, 45, 712–723.
  85. Lopez, A.D.; Mathers, C.D. Measuring the global burden of disease and epidemiological transitions: 2002–2030. Ann. Trop. Med. Parasitol. 2006, 100, 481–499.
  86. Mehesare, S.S.; Waghmare, S.P.; Thorat, M.G.; Hajare, S.W.; Itankar, P.R. Evaluation of antidiarrheal activity of polyherbal preparation. J. Pharmacogn. Phytochem. 2017, 6, 723–725.
  87. Mokomane, M.; Kasvosve, I.; De Melo, E.; Pernica, J.M.; Goldfarb, D.M. The global problem of childhood diarrhoeal diseases: Emerging strategies in prevention and management. Ther. Adv. Infect. Dis. 2017, 5, 29–43.
  88. Thiagarajah, J.R.; Kamin, D.S.; Acra, S.; Goldsmith, J.D.; Roland, J.T.; Lencer, W.I.; Muise, A.M.; Goldenring, J.R.; Avitzur, Y.; Martín, M.G. Advances in Evaluation of Chronic Diarrhea in Infants. Gastroenterology 2018, 154, 2045–2059.
  89. Kassaye, K.; Amberbir, A.; Getachew, B.; Mussema, Y. A historical overview of traditional medicine practices and policy in Ethiopia. Ethiop. J. Heal. Dev. 2007, 20, 127–134.
  90. Mekonnen, B.; Asrie, A.B.; Wubneh, Z.B. Antidiarrheal Activity of 80% Methanolic Leaf Extract of Justicia schimperiana. Evid. Based Complement. Altern. Med. 2018, 2018, 1–10.
  91. De, P.K.; Pal, A.; Roy, B.C. Effects of aqueous young leaves extract of Mangifera indica on GM (-) microorganisms causing gastro-intestinal disorders. Asian J. Plant Sci. Res. 2014, 4, 23–27.
  92. Yakubu, M.; Salimon, S. Antidiarrhoeal activity of aqueous extract of Mangifera indica L. leaves in female albino rats. J. Ethnopharmacol. 2015, 163, 135–141.
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