Dear Colleagues,

Biomaterials have emerged as a cornerstone of modern medicine, driving innovation across prevention, diagnosis, therapy, and regenerative healthcare. Advances in materials science, chemistry, and bioengineering now enable the design of biomaterials with highly controlled physicochemical and biological properties. Far beyond their early role as passive substitutes, contemporary biomaterials actively modulate biological processes, promote repair, and restore function, thereby reshaping therapeutic possibilities.

This Topical Collection, “Applications of Biomaterials in Medicine”, provides a focused platform for publishing studies that demonstrate the potential and versatility of biomaterials in medical practice. We welcome contributions spanning, but not limited to, the following:

• Tissue engineering and regenerative medicine
• Drug and gene delivery systems
• Medical implants and prosthetics
• Wound healing and tissue repair
• Biosensors and diagnostic platforms
• Patient-specific and personalized therapeutic approaches

Priority will be given to interdisciplinary studies that integrate fundamental science with translational or clinical perspectives. Manuscripts should aim to advance understanding of biomaterial performance, biocompatibility, safety, and long-term functionality, while also addressing current challenges and unmet clinical needs.

We invite researchers to contribute entries and comprehensive reviews that critically assess emerging trends and propose future directions. By consolidating diverse insights, this Topical Collection seeks to foster dialogue across disciplines, accelerate the translation of laboratory innovations into clinical applications, and highlight the transformative role of biomaterials in improving patient outcomes.

Prof. Dr. Maria Pia Ferraz
Prof. Dr. Susana R. Sousa
Collection Editors