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HandWiki is the world's largest wiki-style encyclopedia dedicated to science, technology and computing. It allows you to create and edit articles as long as you have external citations and login account. In addition, this is a content management environment that can be used for collaborative editing of original scholarly content, such as books, manuals, monographs and tutorials.

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Opioid Epidemic
The opioid epidemic or opioids crisis is the rapid increase in the use of prescription and non-prescription opioid drugs in the United States and Canada beginning in the late 1990s and continuing throughout the next two decades. The increase in opioid overdose deaths has been dramatic, and opioids are now responsible for 49,000 of the 72,000 drug overdose deaths overall in the US in 2017. A recent report indicated that the rate of prolong opioid use is increasing globally. Opioids are a diverse class of moderately strong painkillers, including oxycodone (commonly sold under the trade names OxyContin and Percocet), hydrocodone (Vicodin, Norco), and a very strong painkiller, fentanyl, which is synthesized to resemble other opiates such as opium-derived morphine and heroin. The potency and availability of these substances, despite their high risk of addiction and overdose, have made them popular both as medical treatments and as recreational drugs. Due to their sedative effects on the part of the brain which regulates breathing, the respiratory center of the medulla oblongata, opioids in high doses present the potential for respiratory depression, and may cause respiratory failure and death. In a 2015 report, the U.S. Drug Enforcement Administration stated that "overdose deaths, particularly from prescription drugs and heroin, have reached epidemic levels.":iii Nearly half of all opioid overdose deaths in 2016 involved prescription opioids. From 1999 to 2008, overdose death rates, sales, and substance abuse treatment admissions related to opioid pain relievers all increased substantially. By 2015, there were more than 50,000 annual deaths from drug overdose, causing more deaths than either car accidents or guns. Drug overdoses have since become the leading cause of death of Americans under 50, with two-thirds of those deaths from opioids. In 2016, the crisis decreased overall life expectancy of Americans for the second consecutive year. Overall life expectancy fell from 78.7 to 78.6 years. Men were disproportionately more affected due to higher overdose death rates, with life expectancy declining from 76.3 to 76.1 years. Women's life expectancy remained stable at 81.1 years. In 2016, over 64,000 Americans died from overdoses, 21 percent more than the almost 53,000 in 2015. By comparison, the figure was 16,000 in 2010, and 4,000 in 1999. While death rates varied by state, public health experts estimate that nationwide over 500,000 people could die from the epidemic over the next 10 years. In Canada , half of the overdoses were accidental, while a third were intentional. The remainder were unknown. Many of the deaths are from an extremely potent opioid, fentanyl, which is trafficked from Mexico. The epidemic cost the United States an estimated $504 billion in 2015. CDC former director Thomas Frieden said that "America is awash in opioids; urgent action is critical." The crisis has changed moral, social, and cultural resistance to street drug alternatives such as heroin. Many state governors have declared a "state of emergency" to combat the opioid epidemic or undertook other major efforts against it. In July 2017, opioid addiction was cited as the "FDA's biggest crisis". In October 2017, President Donald Trump concurred with his Commission's report and declared the country's opioid crisis a "public health emergency". Federal and state interventions are working on employing health information technology in order to expand the impact of existing drug monitoring programs. Recent research shows promising results in mortality and morbidity reductions when a state integrates drug monitoring programs with health information technologies and shares data through centralized platform.
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  • 29 Sep 2022
Topic Review
BeeGFS
BeeGFS (formerly FhGFS) is a parallel file system, developed and optimized for high-performance computing. BeeGFS includes a distributed metadata architecture for scalability and flexibility reasons. Its most used and widely known aspect is data throughput. BeeGFS was originally developed at the Fraunhofer Center for High Performance Computing in Germany by a team around Sven Breuner, who later became the CEO of ThinkParQ (2014 - 2018), the spin-off company that was founded in 2014 to maintain BeeGFS and offer professional services. Whilst the Community Edition of BeeGFS can be downloaded and used free of charge, the Enterprise Edition must be used under a professional support subscription contract.
  • 1.3K
  • 29 Sep 2022
Topic Review
Control Flow Graph
A control flow graph (CFG) in computer science is a representation, using graph notation, of all paths that might be traversed through a program during its execution. The control flow graph is due to Frances E. Allen, who notes that Reese T. Prosser used boolean connectivity matrices for flow analysis before. The CFG is essential to many compiler optimizations and static analysis tools.
  • 13.8K
  • 28 Sep 2022
Topic Review
Buddhism in Buryatia
Buddhism in Buryatia—a regional form of Buddhism.
  • 1.9K
  • 28 Sep 2022
Topic Review
Areas of Mathematics
Mathematics encompasses a growing variety and depth of subjects over its history, and comprehension of it requires a system to categorize and organize these various subjects into more general areas of mathematics. A number of different classification schemes have arisen, and though they share some similarities, there are differences due in part to the different purposes they serve. A traditional division of mathematics is into pure mathematics; mathematics studied for its intrinsic interest, and applied mathematics; the mathematics that can be directly applied to real-world problems. This division is not always clear and many subjects have been developed as pure mathematics to find unexpected applications later on. Broad divisions, such as discrete mathematics, computational mathematics and so on have emerged more recently. An ideal system of classification permits adding new areas into the organization of previous knowledge, and fitting surprising discoveries and unexpected interactions into the outline. For example, the Langlands program has found unexpected connections between areas previously thought unconnected, at least Galois groups, Riemann surfaces and number theory.
  • 6.9K
  • 29 Sep 2022
Topic Review
Mosaic Evolution
Mosaic evolution (or modular evolution) is the concept, mainly from palaeontology, that evolutionary change takes place in some body parts or systems without simultaneous changes in other parts. Another definition is the "evolution of characters at various rates both within and between species".408 Its place in evolutionary theory comes under long-term trends or macroevolution.
  • 3.5K
  • 28 Sep 2022
Topic Review
Civic Technology
Civic technology, or civic tech, enhances the relationship between the people and government with software for communications, decision-making, service delivery, and political process. It includes information and communications technology supporting government with software built by community-led teams of volunteers, nonprofits, consultants, and private companies as well as embedded tech teams working within government.
  • 3.6K
  • 29 Sep 2022
Topic Review
Cold Start (Computing)
Cold start is a potential problem in computer-based information systems which involve a degree of automated data modelling. Specifically, it concerns the issue that the system cannot draw any inferences for users or items about which it has not yet gathered sufficient information.
  • 848
  • 28 Sep 2022
Topic Review
E-Book
An electronic book, also known as an e-book or eBook, is a book publication made available in digital form, consisting of text, images, or both, readable on the flat-panel display of computers or other electronic devices. Although sometimes defined as "an electronic version of a printed book", some e-books exist without a printed equivalent. E-books can be read on dedicated e-reader devices, but also on any computer device that features a controllable viewing screen, including desktop computers, laptops, tablets and smartphones. In the 2000s, there was a trend of print and e-book sales moving to the Internet, where readers buy traditional paper books and e-books on websites using e-commerce systems. With print books, readers are increasingly browsing through images of the covers of books on publisher or bookstore websites and selecting and ordering titles online; the paper books are then delivered to the reader by mail or another delivery service. With e-books, users can browse through titles online, and then when they select and order titles, the e-book can be sent to them online or the user can download the e-book. By the early 2010s, e-books had begun to overtake hardcover by overall publication figures in the U.S. The main reasons for people buying e-books are possibly lower prices, increased comfort (as they can buy from home or on the go with mobile devices) and a larger selection of titles. With e-books, "[e]lectronic bookmarks make referencing easier, and e-book readers may allow the user to annotate pages." "Although fiction and non-fiction books come in e-book formats, technical material is especially suited for e-book delivery because it can be [electronically] searched" for keywords. In addition, for programming books, code examples can be copied. The amount of e-book reading is increasing in the U.S.; by 2014, 28% of adults had read an e-book, compared to 23% in 2013. This is increasing, because by 2014 50% of American adults had an e-reader or a tablet, compared to 30% owning such devices in 2013.
  • 7.1K
  • 30 Sep 2022
Topic Review
Diabetes Mellitus Type 2
Diabetes mellitus type 2 (also known as type 2 diabetes) is a long-term metabolic disorder that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. Common symptoms include increased thirst, frequent urination, and unexplained weight loss. Symptoms may also include increased hunger, feeling tired, and sores that do not heal. Often symptoms come on slowly. Long-term complications from high blood sugar include heart disease, strokes, diabetic retinopathy which can result in blindness, kidney failure, and poor blood flow in the limbs which may lead to amputations. The sudden onset of hyperosmolar hyperglycemic state may occur; however, ketoacidosis is uncommon. Type 2 diabetes primarily occurs as a result of obesity and lack of exercise. Some people are more genetically at risk than others. Type 2 diabetes makes up about 90% of cases of diabetes, with the other 10% due primarily to diabetes mellitus type 1 and gestational diabetes. In diabetes mellitus type 1 there is a lower total level of insulin to control blood glucose, due to an autoimmune induced loss of insulin-producing beta cells in the pancreas. Diagnosis of diabetes is by blood tests such as fasting plasma glucose, oral glucose tolerance test, or glycated hemoglobin (A1C). Type 2 diabetes is partly preventable by staying a normal weight, exercising regularly, and eating properly. Treatment involves exercise and dietary changes. If blood sugar levels are not adequately lowered, the medication metformin is typically recommended. Many people may eventually also require insulin injections. In those on insulin, routinely checking blood sugar levels is advised; however, this may not be needed in those taking pills. Bariatric surgery often improves diabetes in those who are obese. Rates of type 2 diabetes have increased markedly since 1960 in parallel with obesity. As of 2015 there were approximately 392 million people diagnosed with the disease compared to around 30 million in 1985. Typically it begins in middle or older age, although rates of type 2 diabetes are increasing in young people. Type 2 diabetes is associated with a ten-year-shorter life expectancy. Diabetes was one of the first diseases described. The importance of insulin in the disease was determined in the 1920s.
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  • 28 Sep 2022
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