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HandWiki is the world's largest wiki-style encyclopedia dedicated to science, technology and computing. It allows you to create and edit articles as long as you have external citations and login account. In addition, this is a content management environment that can be used for collaborative editing of original scholarly content, such as books, manuals, monographs and tutorials.

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Laboratory B in Sunguľ
Laboratory B in Sunguľ was one of the laboratories under the 9th Chief Directorate of the NKVD (MVD after 1946) that contributed to the Soviet atomic bomb project. It was created in 1946 and closed in 1955, when some of its personnel were merged with the second Soviet nuclear design and assembly facility. It was run as a sharashka – a secret scientific facility run as a prison. Laboratory B employed German scientists from 1947 to 1953. It had two scientific divisions, radiochemistry and radiobiophysics; the latter was headed by the world-renowned geneticist N. V. Timofeev-Resovskij. For two years, the renowned German chemist, Nikolaus Riehl was the scientific director.
  • 1.2K
  • 25 Oct 2022
Topic Review
GNU Build System
The GNU Build System, also known as the Autotools, is a suite of programming tools designed to assist in making source code packages portable to many Unix-like systems. It can be difficult to make a software program portable: the C compiler differs from system to system; certain library functions are missing on some systems; header files may have different names. One way to handle this is to write conditional code, with code blocks selected by means of preprocessor directives (#ifdef); but because of the wide variety of build environments this approach quickly becomes unmanageable. Autotools is designed to address this problem more manageably. Autotools is part of the GNU toolchain and is widely used in many free software and open source packages. Its component tools are free software-licensed under the GNU General Public License with special license exceptions permitting its use with proprietary software. The GNU Build System makes it possible to build many programs using a two-step process: configure followed by make.
  • 1.3K
  • 20 Oct 2022
Topic Review
Bovine Herpesvirus 1
Bovine herpesvirus 1 (BoHV-1) is a virus of the family Herpesviridae and the subfamily Alphaherpesvirinae, known to cause several diseases worldwide in cattle, including rhinotracheitis, vaginitis, balanoposthitis, abortion, conjunctivitis, and enteritis. BoHV-1 is also a contributing factor in shipping fever, also known as bovine respiratory disease (BRD). It is spread horizontally through sexual contact, artificial insemination, and aerosol transmission and it may also be transmitted vertically across the placenta. BoHV-1 can cause both clinical and subclinical infections, depending on the virulence of the strain. Although these symptoms are mainly non-life-threatening it is an economically important disease as infection may cause a drop in production and affect trade restrictions. Like other herpesviruses, BoHV-1 causes a lifelong latent infection and sporadic shedding of the virus. The sciatic nerve and trigeminal nerve are the sites of latency. A reactivated latent carrier is normally the source of infection in a herd. The clinical signs displayed are dependent on the virulence of the strain. There is a vaccine available which reduces the severity and incidence of disease. Some countries in Europe have successfully eradicated the disease by applying a strict culling policy. Infection can occur in cattle of any age, but it is most commonly seen between the ages of 6 and 18 months.
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  • 20 Oct 2022
Topic Review
Avoidant Personality Disorder
Avoidant personality disorder (AvPD) is a Cluster C personality disorder in which the main coping mechanism of those affected is avoidance of feared stimuli. Those affected display a pattern of severe social anxiety, social inhibition, feelings of inadequacy and inferiority, extreme sensitivity to negative evaluation and rejection, and avoidance of social interaction despite a strong desire for intimacy. People with AvPD often consider themselves to be socially inept or personally unappealing and avoid social interaction for fear of being ridiculed, humiliated, rejected, or disliked. They often avoid becoming involved with others unless they are certain they will be liked. Childhood emotional neglect (in particular, the rejection of a child by one or both parents) and peer group rejection are associated with an increased risk for its development; however, it is possible for AvPD to occur without any notable history of abuse or neglect.
  • 3.8K
  • 20 Oct 2022
Topic Review
Testis-Determining Factor
An Error has occurred retrieving Wikidata item for infobox Testis-determining factor (TDF), also known as sex-determining region Y (SRY) protein, is a DNA-binding protein (also known as gene-regulatory protein/transcription factor) encoded by the SRY gene that is responsible for the initiation of male sex determination in therian mammals (placental mammals and marsupials). SRY is an intronless sex-determining gene on the Y chromosome. Mutations in this gene lead to a range of disorders of sex development (DSD) with varying effects on an individual's phenotype and genotype. TDF is a member of the SOX (SRY-like box) gene family of DNA-binding proteins. When complexed with the SF1 protein, TDF acts as a transcription factor that causes upregulation of other transcription factors, most importantly SOX9. Its expression causes the development of primary sex cords, which later develop into seminiferous tubules. These cords form in the central part of the yet-undifferentiated gonad, turning it into a testis. The now-induced Leydig cells of the testis then start secreting testosterone, while the Sertoli cells produce anti-Müllerian hormone. SRY gene effects normally take place 6–8 weeks after fetus formation which inhibits the female anatomical structural growth in males. It also works towards developing the dominant male characteristics.
  • 2.6K
  • 25 Oct 2022
Topic Review
History of Geography
This article explores the history of geography.
  • 9.4K
  • 20 Oct 2022
Topic Review
Keychain
A keychain, or keyring, is a small chain, usually made from metal or plastic, that connects a small item to a keyring. The length of a keychain allows an item to be used more easily than if connected directly to a keyring. Some keychains allow one or both ends the ability to rotate, keeping the keychain from becoming twisted, while the item is being used. A keychain can also be a connecting link between a keyring and the belt of an individual. It is usually employed by personnel whose job demands frequent use of keys, such as a security guard, prison officer, janitor, or retail store manager. The chain is often retractable, and therefore may be a nylon rope, instead of an actual metal chain. The chain ensures that the keys remain attached to the individual using them, makes accidental loss less likely, and saves on wear and tear on the pockets of the user.
  • 2.9K
  • 20 Oct 2022
Topic Review
Legends of the Jews
Legends of the Jews is a chronological compilation of aggadah from hundreds of biblical legends in Mishnah, Talmud and Midrash. The compilation consists of seven volumes (four volumes of narrative texts and two volumes of footnotes with a volume of index) synthesized by Louis Ginzberg in manuscript of German language. In 1913, it was translated by Henrietta Szold.
  • 782
  • 20 Oct 2022
Topic Review
Throughput
In general terms, throughput is the rate of production or the rate at which something is processed. When used in the context of communication networks, such as Ethernet or packet radio, throughput or network throughput is the rate of successful message delivery over a communication channel. The data these messages belong to may be delivered over a physical or logical link, or it can pass through a certain network node. Throughput is usually measured in bits per second (bit/s or bps), and sometimes in data packets per second (p/s or pps) or data packets per time slot. The system throughput or aggregate throughput is the sum of the data rates that are delivered to all terminals in a network. Throughput is essentially synonymous to digital bandwidth consumption; it can be analyzed mathematically by applying the queueing theory, where the load in packets per time unit is denoted as the arrival rate (λ), and the throughput, where the drop in packets per time unit, is denoted as the departure rate (μ). The throughput of a communication system may be affected by various factors, including the limitations of underlying analog physical medium, available processing power of the system components, and end-user behavior. When various protocol overheads are taken into account, useful rate of the transferred data can be significantly lower than the maximum achievable throughput; the useful part is usually referred to as goodput.
  • 25.1K
  • 20 Oct 2022
Topic Review
Compulsive Hoarding
Compulsive hoarding, also known as hoarding disorder, is a behavioral pattern characterized by excessive acquisition of and an inability or unwillingness to discard large quantities of objects that cover the living areas of the home and cause significant distress or impairment. Compulsive hoarding behavior has been associated with health risks, impaired functioning, workplace impairment, economic burden, and adverse effects on friends and family members. When clinically significant enough to impair functioning, hoarding can prevent typical uses of space, enough so that it can limit activities such as cooking, cleaning, moving through the house, and sleeping. It can also put the individual and others at risk of fires, falling, poor sanitation, and other health concerns. Researchers have recognized compulsive hoarding as a phenomenon since at least the 1980s, but only recently have begun to study hoarding, and it was first defined as a mental disorder in the 5th edition of the DSM in 2013. It was not clear whether compulsive hoarding is a separate, isolated disorder, or rather a symptom of another condition, such as OCD, but the current DSM lists hoarding disorder as both a mental disability and a possible symptom for OCD. Prevalence rates have been estimated at 2% to 5% in adults, though the condition typically manifests in childhood with symptoms worsening in advanced age, at which point collected items have grown excessive and family members who would otherwise help to maintain and control the levels of clutter have either died or moved away. Hoarding appears to be more common in people with psychological disorders such as depression, anxiety and attention deficit hyperactivity disorder (ADHD). Other factors often associated with hoarding include alcohol dependence and paranoid, schizotypal and avoidance traits.
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  • 20 Oct 2022
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