Interests: Lipid based formulations, self- nanoemulsifying drug delivery systems (SNEDDS), poorly water-soluble dugs, bioavailability enhancement, targeted drug delivery, micelles, nanomedicine, cancer, pharmacokinetics, 3D printing of SNEDDS, Solidification of SNEDDS, Bioactive SNEDDS (Bio-SNEDDS)

Summary:

Dear Colleagues,

Lipid-based self-nanoemulsifying drug delivery systems (SNEDDS) have recently gained enormous interest for their potential pharmaceutical applications. These delivery systems exceeded the applications of enhancing drug solubility and dissolution to allow the targeting of drugs to specific areas and design of novel delivery systems for oral and non-oral routes of administration. Furthermore, their lipid properties (e.g., high solubilizing potential, biocompatibility, biotolerability, biodegradability, and distinct route of absorption) may significantly improve the bioavailability of very poorly water-soluble drugs for a set of administration routes. In general, the incorporation of active compounds in lipid-based drug delivery systems has helped to boost the therapeutic efficacy of poorly soluble drugs, due to high intestinal absorption. The applications of SNEDDS have been extended in the new research arena including 3D printed SNEDDS dosage forms. These features of the lipid-based nanocarriers (enhanced bioavailability, safety, and provide nanodroplets ) have shed a light of hope for the treatment of chronic diseases. Therefore, the interest in lipid-based SNEDDS has been growing, as demonstrated by the number of related patents and scientific papers in the literature.

The Special Issue of the journal Pharmaceutics entitled “Lipid based self-nanoemulsifying drug delivery systems (SNEDDS): Cutting edge applications and new routes of administrations” wishes to cover the recent advances in the development of SNEDDS aimed at the delivery of drugs by different routes of administration, underscoring the extraordinary value of this drug-carrying system in improving the bioavailability and therapeutic efficacy of the encapsulated drugs.

Main text (150 words)

• Optimization of drug solubility and reproducible bioavailability are recognized as one of the major challenges in oral delivery of highly growing poorly soluble drug (PSD, estimated at 40-90%) candidates. Enabling technology, such as self-nanoemulsifying drug delivery systems and their solidification techniques have generated significant attention and gained high priority in recent years for their key roles in the delivery of PSDs. The initial key achievement of these formulation systems is to increase the solubilization of the PSDs by the formation of stable emulsions, and micellar systems. The current presentation aims to demonstrate factors which influence the design of successful self-nanoemulsifying lipid formulations in dosage form (including technology conversion) and affect the fate of the PSDs in GI tract after oral administration. The investigational research within the scope also provide additional information regarding current practice of lipid formulations with a particular emphasis on new applications and designs of self-nanoemulsifying drug delivery systems (SNEDDS). The scope of this issue might also include zeta potential changing of SNEDDS to enhance permeation, Novel SNEDDS solidification techniques such as 3D printing, Application of in-silico studies and experimental design for SNEDDS optimization with less trial and error approach, Bioactive SNEDDS, Sustained release applications of SNEDDS, New routes of SNEDDS administrations; intra-nasal, topical, buccal, Self-double-emulsifying drug delivery system (SDEDDS), Incorporation of room temperature ionic liquids in SNEDDS fabrication, Novel excipients for SNEDDS: natural-based oils, surfactants and co-solvents

Keywords:

• Keyword 1: Oral drug delivery systems
• Keyword 2: Lipid-based formulation
• Keyword 3: Self nanoemulsifying drug delivery systems (SNEDDS)
• Keyword 4: Bioactive self-nanoemulsifying drug delivery systems (Bio-SNEDDS)
• Keyword 5: Self-double-emulsifying drug delivery system (SDEDDS)
• Keyword 6: Sustained release applications of SNEDDS
• Keyword 7: Novel naturally obtained excipients for SNEDDS
• Keyword 8: Zeta potential changing of SNEDDS to enhance permeation
• Keyword 9: New routes of SNEDDS administrations such as intra-nasal, topical, buccal
• Keyword 10: Incorporation of room temperature ionic liquids
• Keyword 11: Nanomedicine
• Keyword 12: Novel solidification methods such as 3D printing, pre-coated adsorbents
• Keyword 13: Application of in-silico studies and experimental design to minimize trial and error
• Keyword 14: Solubility improvement
• Keyword 15: Bioavailability enhancement

List of recent publications: 2022

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1. Ummara, U.; Noreen, S.; Afzal, M.; Zafar, Z. U.; Akhter, M. S.; Iqbal, S.; Hefft, D. I.; Kazi, M.; Ahmad, P., Induced systemic tolerance mediated by plant-microbe interaction in maize (Zea mays L.) plants under hydrocarbon contamination. Chemosphere 2022, 290, 133327.
2. Uddin, S.; Iqbal, J.; Safdar, L. B.; Ahmad, S.; Abbasi, B. A.; Capasso, R.; Kazi, M.; Quraihi, U. M., Green synthesis of BPL-NiONPs using leaf extract of Berberis pachyacantha: characterization and multiple in vitro biological applications. Molecules 2022, 27 (7), 2064.
3. Shariare, M. H.; Pinky, N. J. K.; Abedin, J.; Kazi, M.; Aldughaim, M. S.; Uddin, M. N., Liposomal Drug Delivery of Blumea lacera Leaf Extract: In-Vivo Hepatoprotective Effects. Nanomaterials 2022, 12 (13), 2262.
4. Shariare, M. H.; Khan, M. A.; Al-Masum, A.; Khan, J. H.; Uddin, J.; Kazi, M., Development of Stable Liposomal Drug Delivery System of Thymoquinone and Its In Vitro Anticancer Studies Using Breast Cancer and Cervical Cancer Cell Lines. Molecules 2022, 27 (19), 6744.
5. Shahba, A. A.-W.; Sherif, A. Y.; Elzayat, E. M.; Kazi, M., Combined Ramipril and Black Seed Oil Dosage Forms Using Bioactive Self-Nanoemulsifying Drug Delivery Systems (BIO-SNEDDSs). Pharmaceuticals 2022, 15 (9), 1120.
6. Shah, Z. A.; Yasmin, H.; Nouroz, F.; Hussain, M. D.; Kazi, M., In silico view of MTA1 biochemical signatures in breast malignancy for improvement in immunosurveillance. Journal of King Saud University-Science 2022, 34 (3), 101843.
7. Shah, H.; Madni, A.; Khan, M. M.; Ahmad, F.-u.-D.; Jan, N.; Khan, S.; Rahim, M. A.; Khan, S.; Ali, M. M.; Kazi, M., pH-Responsive Liposomes of Dioleoyl Phosphatidylethanolamine and Cholesteryl Hemisuccinate for the Enhanced Anticancer Efficacy of Cisplatin. Pharmaceutics 2022, 14 (1), 129.
8. Rashid, M. A.; Bilani, M.; Shazly, G.; Kazi, M., Development, Validation and Application of a Novel UHPLC-UV Method for the Simultaneous Determination of Valsartan and Nifedipine in the New Formulation of Self-Nanoemulsifying Drug Delivery Systems. Separations 2022, 9 (11), 325.
9. Naqvi, A. R.; Khan, S. H.; Mittal, D.; Alshaya, H.; Kazi, M.; Sarwat, M., Time-dependent oscillation of pre-MiRNAs, mature MiRNAs and MiRNA targets in tomato plants subjected to varying abiotic stress conditions. Saudi journal of biological sciences 2022, 103157.
10. Kulkarni, V. R.; Kazi, M.; Shahba, A. A.-W.; Radhanpuri, A.; Maniruzzaman, M., Three-Dimensional Printing of a Container Tablet: A New Paradigm for Multi-Drug-Containing Bioactive Self-Nanoemulsifying Drug-Delivery Systems (Bio-SNEDDSs). Pharmaceutics 2022, 14 (5), 1082.
11. Khan, S.; Minhas, M. U.; Aqeel, M. T.; Shah, I.; Khan, S.; Kazi, M.; Warnken, Z. N., Poly (N-Vinylcaprolactam-Grafted-Sodium Alginate) Based Injectable pH/Thermo Responsive In Situ Forming Depot Hydrogels for Prolonged Controlled Anticancer Drug Delivery; In Vitro, In Vivo Characterization and Toxicity Evaluation. Pharmaceutics 2022, 14 (5), 1050.
12. Jalal, K.; Khan, F.; Nawaz, S.; Afroz, R.; Khan, K.; Ali, S. B.; Hao, L.; Khan, S. A.; Kazi, M.; Uddin, R., Anxiolytic, anti-nociceptive and body weight reducing effects of L-lysine in rats: Relationship with brain serotonin an In-Vivo and In-Silico study. Biomedicine & Pharmacotherapy 2022, 152, 113235.
13. Ijaz, U.; Sohail, M.; Usman Minhas, M.; Khan, S.; Hussain, Z.; Kazi, M.; Ahmed Shah, S.; Mahmood, A.; Maniruzzaman, M., Biofunctional Hyaluronic Acid/κ-Carrageenan Injectable Hydrogels for Improved Drug Delivery and Wound Healing. Polymers 2022, 14 (3), 376.
14. Gausuzzaman, S. A. L.; Saha, M.; Dip, S. J.; Alam, S.; Kumar, A.; Das, H.; Sharker, S. M.; Rashid, M. A.; Kazi, M.; Reza, H. M., A QbD Approach to Design and to Optimize the Self-Emulsifying Resveratrol–Phospholipid Complex to Enhance Drug Bioavailability through Lymphatic Transport. Polymers 2022, 14 (15), 3220.
15. Bhat, I. P.; Rather, T. B.; Maqbool, I.; Rashid, G.; Akhtar, K.; Bhat, G. A.; Parray, F. Q.; Syed, B.; Khan, I. Y.; Kazi, M., Connective tissue growth factor expression hints at aggressive nature of colorectal cancer. World Journal of Gastroenterology 2022, 28 (5), 547.
16. Ali, S.; Khan, M. R.; Iqbal, J.; Shah, S. A.; Abbasi, B. A.; Yaseen, T.; Batool, R.; Ali, I.; Hussain, M. D.; Kazi, M., Chemical characterization and evaluation of the nephroprotective potential of Parrotiopsis jacquemontiana (Decne) Rehder and Periploca hydaspidis Falc crude extract in CCl4-induced male Sprague-Dawley rats. Saudi journal of biological sciences 2022, 29 (2), 702-712.
17. Alangari, A.; Alqahtani, M. S.; Mateen, A.; Kalam, M. A.; Alshememry, A.; Ali, R.; Kazi, M.; AlGhamdi, K. M.; Syed, R., Iron oxide nanoparticles: preparation, characterization, and assessment of antimicrobial and anticancer activity. Adsorption Science & Technology 2022, 2022.
18. Afrin, H.; Salazar, C. J.; Kazi, M.; Ahamad, S. R.; Alharbi, M.; Nurunnabi, M., Methods of screening, monitoring and management of cardiac toxicity induced by chemotherapeutics. Chinese Chemical Letters 2022.
19. Abbas, M. N.; Khan, S. A.; Sadozai, S. K.; Khalil, I. A.; Anter, A.; Fouly, M. E.; Osman, A. H.; Kazi, M., Nanoparticles Loaded Thermoresponsive In Situ Gel for Ocular Antibiotic Delivery against Bacterial Keratitis. Polymers 2022, 14 (6), 1135.
20. Alshadidi, A.; Shahba, A. A.-W.; Sales, I.; Rashid, M. A.; Kazi, M., Combined Curcumin and Lansoprazole-Loaded Bioactive Solid Self-Nanoemulsifying Drug Delivery Systems (Bio-SSNEDDS). Pharmaceutics 2021, 14 (1), 2.