Porcine Deltacoronaviruses: History
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Subjects: Veterinary Sciences
Contributor:
Qiuhong Wang

Porcine deltacoronavirus (PDCoV) is an emerging enteropathogenic coronavirus of swine that causes acute diarrhoea, vomiting, dehydration and mortality in seronegative neonatal piglets. PDCoV was first reported in Hong Kong in 2012 and its etiological features were first characterized in the United States in 2014. Currently, PDCoV is a concern due to its broad host range, including humans. Chickens, turkey poults, and gnotobiotic calves can be experimentally infected by PDCoV. 

  • porcine deltacoronaviruses
  • origin
  • evolution
  • cross-species transmission
  • zoonosis

1. Introduction

Coronaviruses (CoVs) are single-stranded, positive-sense RNA viruses belonging to the subfamily Orthocoronavirinae within the family of Coronaviridae. They are classified into four genera: Alphacoronavirus (α-CoV), Betacoronavirus (β-CoV), Gammacoronavirus (γ-CoV), and Deltacoronavirus (δ-CoV). Coronaviruses are important pathogens of both humans and animals, causing diverse diseases. α-CoVs and β-CoVs infect mammals, while γ-CoVs and δ-CoVs primarily infect birds with some mammalian spill over [1][2][3]. Deltacoronaviruses were detected from the rectal swabs of mammalian species, including Asian leopard cats (Prionailurus bengalensis) and Chinese ferret badgers (Melogale moschata) in wet markets, during virological surveillance in southern China between 2005 and 2006 [4]. Since then, δ-CoVs have been detected from a wide range of birds and domestic pigs [5][6][7][8]. The Deltacoronavirus genus was defined by genomic sequence analysis of both avian and mammalian isolates [7]. The prototype porcine deltacoronavirus (PDCoV) HKU15 strain was reported in Hong Kong in 2012 [7]. However, its pathogenic potential was not recognized until 2014 when it was found to be the cause of pig diarrheic outbreaks, initially on several farms in Ohio, then spreading throughout the United States (US) and globally [9][10]. PDCoV infects the intestinal epithelial cells and causes acute watery diarrhoea, vomiting and dehydration in gnotobiotic and conventional piglets [9][11][12]. PDCoV causes clinical signs indistinguishable from those caused by other porcine enteric CoVs, such as porcine epidemic diarrhoea virus (PEDV) and transmissible gastroenteritis virus (TGEV) [13]. The clinical impact, prevalence, and disease severity of PDCoV in the field are lower than those of PEDV [14]. However, PDCoV has a broader host range and, unlike PEDV and TGEV, it could/can infect multiple species, including pigs, chickens, turkeys, cattle and humans [7][15][16][17][18]. This review focuses on the current knowledge on the origin, evolution, cross-species transmission and zoonotic potential of PDCoV. Additionally, we discuss the potential mechanisms for PDCoV interspecies transmission from birds to pigs, then to humans to help understand common mechanisms for the emergence of novel human CoVs, such as the highly pathogenic severe acute respiratory syndrome CoV (SARS-CoV), Middle East respiratory syndrome CoV (MERS-CoV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

2. Origin of PDCoV

The Deltacoronavirus genus was first established by The International Committee on Taxonomy of Viruses (ICTV) in 2012 after the identification of three novel avian coronaviruses (bulbul CoV HKU11, thrush CoV HKU12, and munia CoV HKU13) [6] and seven other novel δ-CoVs (porcine CoV HKU15, white-eye CoV HKU16, sparrow CoV HKU17, magpie robin CoV HKU18, night heron CoV HKU19, wigeon CoV HKU20, and common moorhen CoV HKU21) of birds or pigs [7]. Interestingly, the replicase polyprotein gene (partial cds) of PDCoV HKU15 is closely related (nucleotide identity ≥ 98.88%) to those δ-CoVs (GenBank accession no. EF584909–EF584912) detected in 2006 from the Chinese ferret badgers at wet markets. Similarly, the polyprotein (orf1b, partial cds), spike (S) protein, envelop (E) protein, membrane (M) protein, non-structure protein 6 (NS6), nucleocapsid (N) protein and non-structure protein 7 (NS7) genes of HKU15 share 98.70% nucleotide identity with those of the δ-CoV (GenBank accession no. EF584908) detected from an Asian leopard cat [7]. More importantly, a recent retrospective study has confirmed the presence of PDCoV (CHN/AH/2004) in diarrheic pigs as early as 2004 in Anhui Province, China [19]. These facts suggest that these mammalian δ-CoVs directly or indirectly evolved from avian δ-CoVs. The transmission direction between the small wild carnivores and pigs is still unknown: (1) The wild small carnivore mammals could have been infected through catching and eating δ-CoV-positive birds [20] and could/can act as the intermediate hosts to transmit PDCoV to pigs; or (2) the wild small carnivore mammals could have been infected as they were fed PDCoV-positive pig viscera, which was used as carnivore food in wet markets (Haitao Xiu, personal communication). Natural PDCoV infection of these two mammalian species has not been reported since 2007, even with additional surveillance attempts [7], further supporting the second possibility, although it needs to be validated with more data in the future. Phylogenetic and recombination analyses suggest that PDCoV might have resulted from several recombination events involving δ-CoVs from several avian species, such as sparrow δ-CoVs HKU17 and ISU73347, and quail δ-CoV HKU30 (Figure 1) [8][21]. Recent studies indicate that aquatic birds may serve as natural reservoirs for δ-CoVs, while terrestrial birds and mammalian species may represent spill over hosts [22][23]. Sparrows, one of the most common birds at pig farms during the wintertime, late fall, and early spring, could promote the transmission of δ-CoVs to pigs. For example, bird droppings in the farms or in contaminated feed grains may be consumed by pigs [24].
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Figure 1. Identification of PDCoV-AH2004 strain as potential recombinant strain using Recombination Identification Program (http://www.hiv.lanl.gov/content/sequence/RIP/RIP.html, accessed on: 28 November 2021). At each position of the window, the query sequence PDCoV-AH2004 was compared with background sequences for 5 avian δ-CoVs (sparrow δ-CoVs HKU17 and ISU73347, quail δ-CoV HKU30, munia δ-CoV HKU13, and bulbul δ-CoV HKU11). The x-axis represents the length of the PDCoV genome, and the y-axis represents the similarity value. When the query sequence is like the background sequence, the homologous regions are indicated as thick dashed lines (of the corresponding color) on the top of the plot. Arrows represent potential recombination breakpoints.
Because the S gene of CoVs is the main genetic determinant of CoV host, tissue, or cellular tropism [25][26][27], Niu et al. [28] and Alhamo et al. [29] tested whether the spike protein or receptor-binding domain (RBD) from the sparrow δ-CoVs could alter PDCoV host and tissue tropism. First, Niu et al. [28] generated an infectious cDNA clone of PDCoV OH-FD22 strain (icPDCoV) and constructed two chimeric icPDCoVs harbouring the spike protein of HKU17 (icPDCoV-SHKU17) or the RBD of ISU73347 (icPDCoV-RBDISU). Niu et al. [28] and Alhamo et al. [29] evaluated their replication in the porcine kidney cell line LLC-PK1 and chicken fibroblast cell line DF-1 and performed pathogenesis studies in 4-day-old gnotobiotic pigs, 8-day-old turkey poults, and 11-day-old embryonated chicken eggs (ECEs). Compared with icPDCoV, the two chimeric viruses replicated to lower titers in LLC-PK1 cells. They did not cause clinical signs in pigs and replicated weakly in the nasal cavity but not in the intestines of pigs, whereas icPDCoV replicated mainly in the pig intestines and weakly in the respiratory tract. The two chimeric viruses and icPDCoV did not replicate in DF-1 cells at a multiplicity of infection (MOI) of 0.01 and did not replicate in the turkey poults or ECEs. Thus, these data indicate that the spike protein of sparrow δ-CoV HKU17 and the RBD of sparrow δ-CoV ISU73347 reduced PDCoV replication in pigs, suggesting limited potential for direct cross-species spillover from current sparrow strains to pigs. Recent molecular clock analyses suggest that PDCoVs shared a common ancestor with sparrow CoVs around 1810 and PDCoVs emerged around the 1990s [21].
Collectively, these studies suggest that PDCoV could have originated from terrestrial birds (e.g., sparrows) or less likely from other unknown wild mammalian δ-CoVs (Figure 2). Clearly, a better understanding of PDCoV origin requires detailed epidemiological studies of δ-CoVs in different species of birds and mammals.
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Figure 2. Likely origin and routes of cross-species transmission of PDCoV. The red dashed line indicates potential, but unknown, transmission of δ-CoVs from avian to mammalian species; the blue dashed line indicates potential transmission of PDCoV based on epidemiology or experimental studies.

3. Molecular Epidemiology and Genetic Diversity of PDCoVs

3.1. Prevalence of PDCoV in Different Countries

To date, PDCoV has been detected in Hong Kong, the United States, Canada, South Korea, mainland China, Thailand, Vietnam, Laos, Taiwan, Japan, Mexico and Haiti. The first documented PDCoV HKU15-44 and HKU15-155 strains were detected from the faecal samples collected from healthy pigs in 2009–2010 from a large-scale animal surveillance study in Hong Kong [7]. Subsequently, in early 2014, PDCoV associated diarrhoea outbreaks were first reported in three states of the US (Ohio, Iowa and Illinois). Later studies showed that PDCoV had spread to many Asian countries (China, Japan, Korea, Laos, Thailand, and Vietnam) and North American countries (the US, Canada, and Mexico) [10][30][31]. In the US, a retrospective surveillance study using reverse transcription-PCR (RT-qPCR) showed that PDCoV RNA was detected as early as August 2013 in pig faecal samples collected from Minnesota, Iowa and Illinois [32]. Furthermore, an indirect PDCoV S1 protein-based enzyme linked immunosorbent assay (ELISA) test suggested an even earlier presence of PDCoV IgG antibody in four archived serum samples collected in 2010 from US pigs [33]. In response to the large number of Swine Enteric Coronavirus Disease (SECD) cases since 2014, the United States Department of Agriculture (USDA) issued a federal order in June 2014, making SECD (caused by PEDV or PDCoV) reportable diseases, which was rescinded on 6 March 2018. According to the last SECD weekly situation report on 8 March 2018, 300 confirmed PDCoV positive premises and 88 presumptive positive premises cumulated between June 2014 and March 2018 and were distributed in 18 states within the US (https://www.aasv.org/pedv/SECD_Situation_Report_180308.pdf; accessed on: 15 October 2021). To date, PDCoV diarrhea occurs at a relatively low reported case rate according to the Swine Health Information Center (https://www.swinehealth.org/domestic-disease-surveillance-reports/; accessed on: 15 October 2021).
In mainland China, PDCoV was first reported in 2015 [19][34][35][36]; however, retrospective studies have shown that PDCoV could have emerged as a swine pathogen as early as 2004 [19]. A recent PDCoV surveillance study reported that 94 (13.07%) of 719 porcine diarrhoea samples collected from 18 provinces in China from March 2016 to June 2018 were PDCoV-positive by RT-qPCR [37]. The complete S genes of 11 PDCoV strains were determined. Seven were expectedly grouped into the Chinese lineage. However, CH-WH-2017 (GenBank accession no. MK040451) exhibited a closer relationship to the US/Japan/South Korea lineage; CH-HA3-2017, CH-HA1-2017 and CH-HA2-2017 strains (GenBank accession no. MK040455, MK040453 and MK040454) were clustered into a new branch and separate from the Chinese lineage. The latter showed the closest relationship to the Vietnam/Laos/Thailand lineage [37]. As of October 2021, PDCoV has been detected in 26 provinces of China, including all swine producing areas [35][37][38][39][40][41][42]. From mid-March 2014 to January 2016, PDCoV related diarrhoea outbreaks were successively identified in Canada, South Korea, Thailand, Vietnam, and Laos [30][43][44][45]. Retrospective studies revealed that PDCoV has been circulating in Taiwan [46], Japan [47], Mexico [48] and Haiti [18] since 2011, late 2013, 2015 and 2014, respectively. PDCoVs or PDCoV-like δ-CoVs have not been detected in the Europe, South American, African, and Australian continents, although retrospective studies have been conducted in Brazil [49] and Spain [50] to identify CoVs in wild birds and pigs, respectively.

3.2. Genetic Diversity of Global PDCoV

To date, 122 complete genome sequences of PDCoVs are available in GenBank (Table 1 and Figure 3). Phylogenetic analysis of these PDCoV genome sequences showed that all US, South Korean and Japanese strains clustered together; and three Chinese isolates (CHN-GD16-05/2016; CHzmd2019; CH-HLJ-20/2020) and one Haiti isolate (PDCoV/Haiti/Human/0256-1/2015) appeared to be more closely related to US/South Korean/Japanese strains. Therefore, these latter four strains were classified into the US linage (Figure 3). Similarly, He et al. found two other newly sequenced Chinese strains (AH2019/H and SD2019/426, GenBank accession no. are not available) were also clustered into the US lineage [10]. The close genetic relatedness between Chinese and US PDCoVs is not surprising due to the frequent trade of pork and pork products and pig feed supplements (https://www.fas.usda.gov/china-2020-export-highlights; accessed on: 10 November 2021). Additionally, it is not surprising to see that one of the three Haitian PDCoVs detected from children grouped within US lineage because pigs were re-introduced from the US to Haiti after the local pig population was mostly wiped out following the African Swine Fever epidemic in 1970s–1980s [51]. The early Chinese lineage contains the earliest strain that was detected from a sample collected in the Anhui Province in 2004 (CHN-AH-2004) and the strains isolated in Hong Kong in 2009 (HKU15-44) and 2010 (HKU15-155). The Chinese lineage is also inclusive of the two Haiti PDCoVs (PDCoV/Haiti/Human/0081-4/2014 and PDCoV/Haiti/Human/0329-4/2015) and the currently circulating strains in mainland China. The two Haitian strains are closely related to a Chinese strain (CHN/Tianjin/2016). According to the pork trade data from the Observatory of Economic Complexity (OEC), Chinese pork was exported to Haiti from 2006 to 2011 (https://oec.world/en/visualize/tree_map/hs92/import/hti/show/10203/2012/; accessed on: 10 November 2021). This may have contributed to PDCoV transmission from China to Haiti. The Southeast Asian (or Vietnam/Laos/Thailand) lineage contains PDCoV strains prevailing in these countries and a novel strain detected in China (CHN/GX/1468B/2017), indicating that these strains may derive from common evolutionary ancestors [52]. In addition, another Thailand-like PDCoV isolate (CHN-GX81-2018) was also discovered in Guangxi Province of China [53]. Collectively, phylogenetic analysis demonstrated that multiple PDCoV lineages, including US lineage, early Chinese lineage, Chinese lineage, and Vietnam/Laos/Thailand lineage, coexist in mainland China. He et al. [10] reported that more frequent intra- and inter-lineage recombination and higher virus genetic diversity were identified among and within the Vietnam/Laos/Thailand and Chinese lineages than within the US lineage. Frequent recombination events between different lineages of PDCoV strains in China may complicate PDCoV epidemiology and result in the emergence of PDCoV strains with changed pathogenicity and host tropism.
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Figure 3. Phylogenetic analyses of PDCoV based on 122 complete genomes. Genome sequences were aligned with MAFFT v.7.490 [54]. The phylogenetic tree was constructed using the neighbour-joining method of MEGA 11, and bootstrap values (1000 replicates) above 70% are shown. The bar represents a corrected genetic distance. The red circles indicate PDCoV strains from China but that fall into non-Chinese lineages; the blue circles indicate PDCoV strains from humans in Haiti.
Table 1. Complete genome information on PDCoV strains.
Lineage GenBank Accession No. Strain Name Countries Collection Date Host Reference
US KJ462462.1 OH1987 USA 31-Jan-2014 Pig [9]
  KJ481931.1 PDCoV/USA/Illinois121/2014 USA 04-Jan-2014 Pig [55]
  KJ567050.1 8734/USA-IA/2014 USA 20-Feb-2014 Pig [56]
  KJ569769.1 IN2847 USA 13-Feb-2014 Pig [57]
  KJ584355.1 IL2768 USA 12-Feb-2014 Pig [58]
  KJ584356.1 SD3423 USA 20-Feb-2014 Pig [58]
  KJ584357.1 KY4813 USA 07-Mar-2014 Pig [58]
  KJ584358.1 PA3148 USA 18-Feb-2014 Pig [58]
  KJ584359.1 NE3579 USA 21-Feb-2014 Pig [58]
  KJ620016.1 MI6148 USA 18-Mar-2014 Pig [58]
  KM012168.1 Michigan/8977/2014 USA 17-Mar-2014 Pig Unpublished
  KR150443.1 USA/Arkansas61/2015 USA 24-Mar-2015 Pig Unpublished
  KR265847.1 USA/Minnesota442/2014 USA 06-Mar-2014 Pig Unpublished
  KR265848.1 USA/Minnesota214/2014 USA 14-Mar-2014 Pig Unpublished
  KR265849.1 USA/Michigan447/2014 USA 02-Apr-2014 Pig Unpublished
  KR265850.1 USA/Michigan448/2014 USA 02-Apr-2014 Pig Unpublished
  KR265851.1 USA/Indiana453/2014 USA 13-May-2014 Pig Unpublished
  KR265852.1 USA/Illinois449/2014 USA 21-Apr-2014 Pig Unpublished
  KR265853.1 USA/Minnesota/2013 USA 14-Oct-2013 Pig Unpublished
  KR265854.1 USA/Minnesota454/2014 USA 21-May-2014 Pig Unpublished
  KR265855.1 USA/Minnesota455/2014 USA 21-May-2014 Pig Unpublished
  KR265856.1 USA/Illinois272/2014 USA 23-Feb-2014 Pig Unpublished
  KR265857.1 USA/Illinois273/2014 USA 23-Feb-2014 Pig Unpublished
  KR265858.1 USA/NorthCarolina452/2014 USA 06-May-2014 Pig Unpublished
  KR265859.1 USA/Minnesota159/2014 USA 11-Feb-2014 Pig Unpublished
  KR265860.1 USA/Nebraska209/2014 USA 05-Feb-2014 Pig Unpublished
  KR265861.1 USA/Nebraska210/2014 USA 05-Feb-2014 Pig Unpublished
  KR265862.1 USA/Ohio444/2014 USA 26-Mar-2014 Pig Unpublished
  KR265863.1 USA/Ohio445/2014 USA 27-Mar-2014 Pig Unpublished
  KR265864.1 USA/Minnesota292/2014 USA 14-Mar-2014 Pig Unpublished
  KR265865.1 USA/Iowa459/2014 USA 05-Jun-2014 Pig Unpublished
  KT381613.1 OH11846 USA 07-May-2014 Pig [59]
  KX022602.1 PDCoV/USA/Iowa136/2015 USA 15-Oct-2015 Pig Unpublished
  KX022603.1 PDCoV/USA/Minnesota140/2015 USA 18-Dec-2015 Pig Unpublished
  KX022604.1 PDCoV/USA/Nebraska137/2015 USA 27-Nov-2015 Pig Unpublished
  KX022605.1 PDCoV/USA/Nebraska145/2015 USA 21-Dec-2015 Pig Unpublished
  MZ291567.1 OH-FD22 P7 USA 2014 Pig [60]
  KY354363.1 DH1 South Korea 01-Apr-2016 Pig [61]
  KY354364.1 DH2 South Korea 01-Apr-2016 Pig [61]
  KY364365.1 KNU16-07 South Korea Jul-2014 Pig [62]
  KY926512.1 KNU16-11 South Korea Nov-2016 Pig [63]
  KM820765.1 KNU14-04 South Korea Apr-2014 Pig [43]
  LC260038.1 AKT/JPN/2014 Japan May-2014 Pig [47]
  LC260039.1 GNM-1/JPN/2014 Japan May-2014 Pig [47]
  LC260040.1 GNM-2/JPN/2014 Japan May-2014 Pig [47]
  LC260041.1 IWT/JPN/2014 Japan May-2014 Pig [47]
  LC260042.1 MYZ/JPN/2014 Japan May-2014 Pig [47]
  LC260043.1 OKN/JPN/2014 Japan Aug-2014 Pig [47]
  LC260044.1 YMG/JPN/2014 Japan Dec-2014 Pig [47]
  LC260045.1 HKD/JPN/2016 Japan Sep-2016 Pig [64]
  KY363868.1 CHN-GD16-05 China 05-Jan-2016 Pig [65]
  MN781985.1 CHzmd2019 China Unknown Pig Unpublished
  MZ802955.1 CH-HLJ-20 China Sep-2020 Pig Unpublished
  MW685623.1 PDCoV/Haiti/Human/0256-1/2015 Haiti 16-Mar-2015 Human [18]
Early
Chinese		 KP757890.1 CHN-AH-2004 China 24-May-2004 Pig [19]
  KP757891.1 CHN-HB-2014 China 26-Dec-2014 Pig [19]
  JQ065042.2 HKU15-44 China: Hong Kong 2009 Pig [7]
  JQ065043.2 HKU15-155 China: Hong Kong 2010 Pig [7]
  KT336560.1 CHN-HN-2014 China 24-Nov-2014 Pig [66]
  KY513725.1 CH/Jiangsu/2014 China 2014 Pig Unpublished
  MF431742.1 GD China 2015 Pig Unpublished
  MF642322.1 CHN/GS/2016/1 China Aug-2016 Pig [67]
  MF642323.1 CHN/GS/2016/2 China Aug-2016 Pig [67]
  MF642324.1 CHN/GS/2017/1 China Apr-2017 Pig [67]
  MF642325.1 CHN/QH/2017/1 China Mar-2017 Pig [67]
Chinese KP757892.1 CHN-JS-2014 China 20-Dec-2014 Pig [19]
  KR131621.1 PDCoV/CHJXNI2/2015 China Mar-2015 Pig [35]
  KT021234.1 CH/SXD1/2015 China 20-Mar-2015 Pig [34]
  KT266822.1 CH/Sichuan/S27/2012 China 2012 Pig [36]
  KU665558.1 CHN-LYG-2014 China 26-Jun-2014 Pig Unpublished
  KU981059.1 NH China 16-Feb-2015 Pig Unpublished
  KX443143.2 CH-01 China 2016 Pig [68]
  KY065120.1 CHN/Tianjin/2016 China 2016 Pig [69]
  KY293677.1 CH/JXJGS01/2016 China 23-May-2016 Pig [70]
  KY293678.1 CH/JXJGS02/2016 China 23-May-2016 Pig Unpublished
  KY363867.1 CHN-GD16-03 China 18-Mar-2016 Pig [65]
  KY513724.1 CH/Hunan/2014 China 2014 Pig Unpublished
  MF041982.1 SHJS/SL/2016 China 23-Dec-2016 Pig [71]
  MF095123.1 CHN-HG-2017 China 15-Feb-2017 Pig [72]
  MF280390.1 CHN-GD-2016 China 2016 Pig [73]
  MF431743.1 SD China 2014 Pig Unpublished
  MF948005.1 HB-BD China 10-Aug-2017 Pig [74]
  MG242062.1 CHN-HeB1-2017 China 2017 Pig Unpublished
  MG832584.1 CHN-HN-1601 China Jul-2016 Pig [75]
  MH708123.1 HNZK-02 China 20-Mar-2018 Pig [68]
  MH708124.1 HNZK-04 China 20-Mar-2018 Pig [76]
  MH708125.1 HNZK-06 China 20-Mar-2018 Pig [76]
  MH715491.1 PDCoV/CHGD/2016 China 2016 Pig Unpublished
  MK005882.1 Swine/CHN/SC/2018/1 China Mar-2018 Pig Unpublished
  MK211169.1 CHN/Sichuan/2017 China 24-Dec-2017 Pig Unpublished
  MK330604.1 CHN/Sichuan/2017 China Feb-2017 Pig Unpublished
  MK330605.1 CHN/Sichuan/2018 China Jan-2018 Pig Unpublished
  MK355396.1 CHN-SC2015 China 20-Feb-2016 Pig [77]
  MK359104.1 CHN-GX01-2018 China 2018 Pig [53]
  MK572803.1 SCNC201705 China Jun-2017 Pig Unpublished
  MK625638.1 CH/JXJGS01/2016 China Oct-2018 Pig [70]
  MK625639.1 CH/JXJGS01/2016 China Oct-2018 Pig [70]
  MK625640.1 CH/JXJGS01/2016 China Oct-2018 Pig [70]
  MK625641.1 CH/JXJGS01/2016 China Oct-2018 Pig [70]
  MK993519.1 CHN/Sichuan/2019 China Jan-2019 Pig Unpublished
  MN173779.1 CHN-GX11-2018 China 2018 Pig [53]
  MN173780.1 CHN-GX12-2018 China 2018 Pig [53]
  MN173781.1 CHN-GX81-2018 China 2018 Pig [53]
  MN173782.1 CHN-GX09-2018 China 2018 Pig [53]
  MN249445.1 CHN-JS-2017 China 11-Dec-2017 Pig [78]
  MN942260.1 PDCoV HeN/swine/2015 China 2015 Pig Unpublished
  MW854634.1 104-553 China: Taiwan Jun-2015 Pig [46]
  MT663769.1 CHN-TS1-2019 China 23-Jul-2019 Pig Unpublished
  MW685622.1 PDCoV/Haiti/Human/0081-4/2014 Haiti 15-Dec-2014 Human [18]
  MW685624.1 PDCoV/Haiti/Human/0329-4/2015 Haiti 13-Apr-2015 Human [18]
Vietnam/
Laos/
Thailand		 KU051641.1 PDCoV/Swine/Thailand/S5011/2015 Thailand 10-Jun-2015 Pig [79]
  KU051649.1 PDCoV/Swine/Thailand/S5015L/2015 Thailand 30-Jun-2015 Pig [79]
  KU984334.1 TT_1115 Thailand Nov-2015 Pig [80]
  KX118627.1 P1_16_BTL_0115/PDCoV/2016/Lao Laos 20-Jan-2016 Pig [44]
  KX361343.1 P1_13_ST1_0213/PDCoV/0213/Thailand Thailand Feb-2013 Pig [81]
  KX361344.1 P2_13_ST2_0313/PDCoV/0213/Thailand Thailand Mar-2013 Pig [81]
  KX361345.1 P24_15_NT1_1215/PDCoV/2015/Thailand Thailand Dec-2015 Pig [81]
  KX834351.1 PDCoV/Swine/Vietnam/HaNoi6/2015 Vietnam 10-Oct-2015 Pig [82]
  KX834352.1 PDCoV/Swine/Vietnam/Binh21/2015 Vietnam 08-Dec-2015 Pig [82]
  KX998969.1 P29_15_VN_1215 Vietnam Dec-2015 Pig Unpublished
  MH118332.1 P19_16_VN_0416 Vietnam Unknown Pig [83]
  MN025260.1 CH/GX/1468B/2017 China 18-Jan-2017 Pig [52]

3.3. Co-Infection of PDCoV with Other Porcine Enteric Viruses

Clinical signs associated with PDCoV infection were found to be less severe than PEDV infection, and the PDCoV prevalence rate in diarrheic pigs is about 30% [7][9][30]. Nevertheless, co-infection with other enteric viral pathogens, such as PEDV, transmissible gastroenteritis virus (TGEV) and porcine rotavirus (PRV), are common and may lead to more severe clinical disease [30][37][41][84][85]. Recent surveys conducted in the United States, Mexico, South Korea and mainland China found that PEDV is the most frequent co-infecting pathogen with PDCoV, with a detection rate ranging from 4.73% to 54.10% (Table 2). Furthermore, except for the US, multiple-infection cases with both PDCoV and two other viruses (PEDV, TGEV, or PRV) were identified in other countries, with a detection rate ranging from 0.12% to 18.80% (Table 2). Additionally, a recent study found the co-infection of PDCoV with 4 to 7 other viral pathogens in diarrhoea samples collected in China from 2015 to 2018. These pathogens were porcine astrovirus (PAstV), porcine teschovirus (PTV), porcine sapelovirus (PSV), porcine enterovirus (PEV) 9/10, torque teno sus virus 2 (TTSuV-2), mammalian reovirus (MRV), porcine torovirus (PToV), porcine kobuvirus (PKV) or porcine bocavirus (PBoV) (Table 2).
Table 2. Co-infection of PDCoV with other porcine enteric viruses in pig farms or diarrheic samples from 2012 to 2018.
Year Country Pathogens Positive Farms/Samples
(Positive Rate)		 References
2014–2018 United States PDCoV + PEDV 307 [86]
2014–2017 Mexico PDCoV + PEDV 46 (54.1%) [48]
PDCoV + TGEV 9 (10.6%)
PDCoV + PEDV + TGEV 16 (18.8%)
2014–2016 South Korea PDCoV + PEDV 43 (6.3%) [63]
PDCoV + PRV 19 (2.78%)
PDCoV + PEDV + PRV 2 (0.29%)
2016–2018 China PDCoV + PEDV 34 (4.73%) [37]
2012–2018 PDCoV + PEDV 380 (46.74%) [41]
PDCoV + TGEV 30 (3.69%)
PDCoV + PEDV + PRV 3 (0.37%)
PDCoV + PEDV + TGEV 1 (0.12%)
2015–2018 PDCoV + PAstV + PEV + TTSuV-2 + MRV + PKV 1 (1.12%) [87]
PDCoV + PAstV + PEV + PKV + PBoV 1 (1.12%)
PDCoV + PAstV + PTV + PSV + PEV + PKV + PBoV 1 (1.12%)
PDCoV + PAstV + PTV + PSV + PKV + PBoV 1 (1.12%)
PDCoV + PAstV + PTV + PSV + PEV + TTSuV-2 + PKV + PBoV 1 (1.12%)
PDCoV + PAstV + PTV + PEV + TTSuV-2 + PToV + PBoV 1 (1.12%)
PDCoV + PAstV + PEV + TTSuV-2 + PBoV 1 (1.12%)

This entry is adapted from the peer-reviewed paper 10.3390/pathogens11010079

References

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