Medical Services for Insomnia in Korea: History
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Researchers reviewed the National Patient Sample data from the Health Insurance Review and Assessment Service to determine healthcare utilization in patients diagnosed with insomnia (International Classification of Diseases-10 codes G470, F510) between January 2010 and December 2016.

  • insomnia
  • medical service utilization
  • cost of care

1. Introduction

Insomnia is defined as the persistence of symptoms such as difficulty initiating or maintaining sleep or early-morning waking at least three times a week for ≥3 months [1]. Insomnia is a very common disorder, and intermittent short-term insomnia affects approximately 30–50% of the total population. A study in the United States (US) and United Kingdom (UK) reported an acute insomnia prevalence of 9.5% and 7.9%, respectively, with an annual incidence of 31.2–36.6% [2]. A study in Korea reported that one in five adults develops insomnia [3]. The prevalence of insomnia also increases with age; approximately 50% of older adults have difficulty initiating or maintaining sleep [4]. Further, the prevalence of insomnia according to the International Classification of Sleep Disorders-2 (ICSD-2) criteria was 32.7% among Korean older adults [5].
Insomnia is multifactorial [6]. Smoking, alcohol use, and diminished physical activity are associated with insomnia in older adults. The risk factors for insomnia include being divorced, separated, or widowed (for women); having a low education level; and having a low income level [7]. Insomnia may cause severe pain and injury in the body, as well as fatigue, daytime sleepiness, cognitive impairment, and mood disorders [6]. Sleep deprivation can result in deterioration of the overall quality of life, characterized by depression and poor work performance, and chronic insomnia can increase mortality by activating the inflammatory processes in the body and inducing cardiovascular diseases [8,9].
The goal of insomnia treatment is to improve sleep and reduce any resultant suffering or functional impairments [10]. Cognitive behavioral therapy for insomnia (CBT-I) is suggested as the first-line treatment for adult chronic insomnia by the American College of Physicians clinical practice guidelines (2016), European Sleep Research Society clinical practice guidelines (2017), and American Academy of Sleep Medicine guidelines for the assessment and treatment of adult chronic insomnia (2008) [10,11,12]. In general, CBT-I comprises: (1) education regarding normal sleep, sleep hygiene, and the purpose of CBTI-I, (2) stimulus control therapy, (3) sleep restriction therapy, (4) relaxation techniques, and 5) cognitive therapy [13]. If CBT-I alone is inadequate or ineffective, pharmacological therapy can be considered. Appropriate doses of drugs for treating adult sleep initiation and sleep maintenance difficulties are used separately, and pharmacological therapy beyond four weeks is not recommended. Drugs used in Korea for sleep initiation include zolpidem, triazolam, and ramelteon; those used for sleep maintenance or early morning awakenings include eszopiclone, doxepin, trazodone, suvorexant, and zolpidem controlled-release (CR) [14].
The degree of symptom improvement achieved with insomnia treatment differs among patients. Previous studies report an insomnia persistence rate of 40–69% over a period of 1–20 years [15], suggesting that chronic insomnia can be a substantial financial burden on society [16]. According to a World Health Organization report, insomnia is ranked eleventh on the list of mental, neurological and substance-use disorders with the greatest disease burden worldwide [17]. A 2010 European study comparing the direct and indirect costs of various brain diseases ranked insomnia as the ninth among neuropsychiatric disorders [18]. Although specific estimates can vary widely depending on the methodology, insomnia-related direct and indirect cost estimates in the US are reported to be 2–16 billion USD and 75–100 billion USD, respectively [16]. The indirect costs were mostly incurred by worker absenteeism, presenteeism (diminished daytime productivity), and occupational accidents [19]. A Korean epidemiology study on sleep disorders reported that 22.8% of 5000 adults had insomnia [20], and a Health Insurance Review and Assessment Service (HIRA) report showed that the number of patients being treated for insomnia increased from 405,000 in 2015 to 633,000 in 2019, with the total amount of covered health benefits increasing from 38.7 billion KRW in 2012 to 66.7 billion KRW in 2016 [21].
The escalating prevalence of insomnia, and consequent direct and indirect costs of care, demand an examination of the latest trends in insomnia care. As previously mentioned, Western clinical practice guidelines recommend CBT-I followed by pharmacological therapy to treat insomnia. However, there are limitations in the clinical implementation of CBT-I, and medication compliance is low among patients because of concerns regarding developing tolerance and dependence and adverse drug reactions with prolonged use, such as disturbance of sleep flow [22]. As a result, alternative therapy is sometimes used to treat insomnia; popular alternatives include phototherapy, exercise therapy, and acupuncture therapy [10,23,24]. Research on such alternative therapies is ongoing. One study investigating the short-term effects of acupuncture on sleep quality reported that acupuncture improved sleep efficiency and total sleep duration compared with placebo treatment [25]. Acupuncture therapy is less costly compared with psychotherapies, is not time consuming, and can be adjusted depending on the targeted symptom [26].
South Korea features a bimodal healthcare system, wherein patients with insomnia have the option to receive covered care at Western medicine (WM) or Korean medicine (KM) facilities. KM treatments include acupuncture, moxibustion, cupping therapy, herbal medicine, and KM psychotherapy. Korean patients can receive WM and KM treatments concomitantly; therefore, there may be differences in the limitations of these treatments and their socioeconomic burden in Korea compared with that from other countries, which highlights the need for studies that consider both KM and WM treatments.

2. Healthcare Utilization and Medication Usage

There were approximately 1.7-fold more female patients than male patients among those who sought healthcare for insomnia, which is consistent with previous findings that insomnia more frequently affects women than men [8]. Most patients who sought healthcare for insomnia were in the 55–64 years, 45–54 years, 65–74 years, or ≥75 years age groups, with 73% of the patients aged ≥45 years. There was a high percentage of women aged 45–75 years among patients who sought healthcare for insomnia. The age range of patients seeking KM care for insomnia was 35–74 years, which was similar to the age range of patients seeking KM care for other diseases [33].
Among patients who sought healthcare for insomnia, children and adolescents aged < 15 years accounted for the smallest proportion (0.41%). Although sleep disorders are quite common among children and adolescents, with a prevalence of approximately 27–62% [34], their healthcare utilization may be the lowest because only approximately 50% of caregivers consult a physician for their children’s sleep disorders [35]. Compared to other age groups, children and adolescents aged < 15 years preferred KM care (3.04%) to WM care (0.11%). This contrasts with the preference for WM care (16.13%) over KM care (8.15%) among adults aged ≥75 years. As children and adolescents aged < 15 years have distinct characteristics in terms of healthcare utilization, such as being accompanied by their caregivers when seeking healthcare, further research is needed in this group.
Regarding inpatient and outpatient care utilization as determined based on claims data, outpatient care utilization was remarkably higher than inpatient care at 99.82%. Outpatient care utilization at primary health facilities was high in both KM and WM, with 70.77% utilizing a WM clinic and 15.84% utilizing a KM clinic. Insomnia is a very common health problem, and sleep problems frequently occur alongside existing psychological and physical problems. Thus, the prevalence can be high (above 50%) among patients who visit primary care facilities that are easily accessible [36].
Insomnia is often accompanied by other physical and psychological symptoms [37]. Poor sleep quality and shortened sleep duration may exacerbate symptoms of depression and can contribute to chronic pain by aggravating central sensitization [38]. Previous studies reported that 53% of patients with chronic pain seek healthcare for sleep-related symptoms [39]. Many studies have provided evidence that irritable bowel syndrome, gastro-esophageal reflux disease, and functional dyspepsia are associated with sleep disorders; the likelihood of developing additional sleep dysfunctions and comorbidities such as anxiety and depression increases with increasing severity of dyspepsia [40]. In analysis of comorbidities of insomnia, mental disorders (F codes), musculoskeletal disorders (M codes), and digestive diseases (K codes) ranked in the top three comorbidities in both WM and KM. In WM, a high percentage of patients suffered from mental health issues. In KM, a high percentage of patients had a musculoskeletal disorder. According to the 2017 survey of KM care utilization, musculoskeletal and connective tissue-related conditions were the most common reasons (61.1%) for seeking outpatient KM care, followed by digestive conditions (10.9%) [33]. This result supports previous findings that acupuncture is effective in treating chronic pain associated with musculoskeletal disorders [41].
In a study of patients with insomnia who visited the Sleep Clinic at the National Center for Mental Health in 2018, Soh (2019) reported that these patients had been treated at a different healthcare facility for sleep problems before visiting the Sleep Clinic and that pharmacological treatment (92%) was used in most cases [42]. In light of finding that medication administration was the second-highest category following examination, we can infer that pharmacological treatments are frequently used to treat insomnia in WM. The analysis of frequently prescribed drugs revealed that sedatives and hypnotics were most frequently prescribed, followed by antianxiety drugs and digestive and metabolism-related drugs. Such prescription trends seem to be linked to the top-ranked comorbidities in WM, namely other anxiety disorder (F41), depressive episode (F32), and gastritis and duodenitis (K29).
The most commonly used sedatives and hypnotics were zolpidem, triazolam, and flunitrazepam. Triazolam is a benzodiazepine (BZD) that extends sleep duration and shortens sleep latency; however, withdrawal of the drug may trigger a relapse of insomnia, more severe rebound insomnia, and withdrawal symptoms. Furthermore, triazolam has a short half-life and, thus, may cause more intense withdrawal symptoms. Zolpidem is a BZD receptor agonist that has recently become popular owing to its comparable effects to those of BZDs with reduced tolerance and habituation. Despite the fact that it is effective as a short-term treatment (≤4 weeks) for early- and mid-stage insomnia, the use of zolpidem requires caution as it is associated with similar adverse events to those of BZDs (e.g., cognitive decline and falls) and may cause neuropsychiatric adverse events (e.g., parasomnias, amnesia, hallucinations) [43,44,45]. Thus, hypnotics may be associated with an array of adverse events; in addition, the use of hypnotics is associated with high cancer incidence and mortality [46,47].
There are several challenges in the clinical implementation of CBT-I, the standard non-pharmacological therapy for insomnia, as it is costly and time consuming, and approximately 20% of patients with insomnia are nonresponsive to treatment, with 39–44% failing to retain the therapeutic effects after treatment [21].
According to a study conducted among KM doctors, the most common reason for visiting a KM facility among insomnia patients was to enhance their sleep quality and reduce the use of hypnotics, and the most frequently performed treatment was acupuncture along with the administration of herbal medicine [48]. Among various KM psychotherapies, results showed that ijeong-byeongi therapy and oji-sangseung therapy were most frequently performed (86 cases and 31 cases, respectively). Acupuncture, the most widely performed treatment for insomnia in KM, is associated with few adverse events but high efficacy in the nervous and endocrine systems, and it has been substantiated as an effective alternative medicine modality in many clinical trials [49]. Acupuncture is less costly and can be performed more quickly than psychotherapies. Furthermore, while WM drugs target fixed and specific symptoms of insomnia, acupuncture has an added benefit of adjusting acupoints depending on the targeted symptom [26].
The analysis of the frequency of insomnia codes F510 and G470 revealed that code G470 was more frequently used than code F510 during the study period, and the difference was more evident in KM than in WM. This is consistent with previous findings that KM doctors frequently use code G470 for insomnia [48]. It is possible that they preferred a G code over an F code because of the patients’ psychological burden associated with an F code and the fact that most patients with insomnia also have other symptoms. In 2013, there was an attempt to resolve the negative views and social stigmatization of mental disorders by amending the law to change the main diagnosis to “counseling.” Bias not only leads to discrimination against people with mental disorders in their daily lives but also contributes to building a stereotype and negative image of mental disorders. Private and public sectors may intentionally or unintentionally limit opportunities for individuals with mental disorders [50]. A 2016 survey on mental disorders reported that the rate of mental health service utilization by the Korean population remained markedly low at 9.6%, compared to 43% among the American population (2015) [51]. Hence, changing the perception of mental illnesses and improving mental health services for the affected individuals would be a significant step.
Insomnia often presents as a comorbidity of several other diseases; Thus, it is important to administer individualized treatments for patients by accurately identifying patterns of insomnia, such as difficulty with sleep initiation, maintenance or early morning awakening, as well as each patient’s living environment and medical history [52]. While sleep hygiene education and CBT are recommended as first-line treatments for insomnia, it is difficult to implement these interventions in Korea owing to the relatively high cost, lack of practitioners with expertise, and current medical fee system. Therefore, the numbers of patients seeking healthcare for insomnia and hypnotic prescriptions will inevitably increase. The higher utilization of WM than KM observed in current study is presumably because of drug prescriptions. Hypnotics should be prescribed with caution not only due to the associated adverse reactions but also owing to the issues of rebound insomnia, withdrawal symptoms, and recurrence that occur when medications are reduced or stopped [52]. Performing electroacupuncture while to taper off sleeping pills was effective in reducing adverse reactions that typically occur with prolonged use beyond four weeks [53]. Pragmatic observational studies are required to identify effective concomitant treatments and alternatives to pharmacological treatment that are clinically confirmed to improve sleep.

3. Strengths and Limitations

There are several strengths to this study. Firstly, the data used in this study were collected from the entire population of the country and, thus, are nationally representative. Secondly, researchers observed a long-term period of 7 years, from 2010 to 2016, the latest available data for analysis. Thirdly, this is the first study to analyze trends in insomnia care in both KM and WM in Korea. Researchers analyzed the main treatment modalities and their cost, as well as the frequency of prescribed treatments and medications to treat insomnia, in each specialty.
This study had a few limitations. First, among the cases with insomnia as the main diagnosis, researchers only analyzed those with the code G470 or F510 with reference to the criteria used in previous studies. Hence, patients who were treated for insomnia with other codes as the main diagnosis or sub-diagnosis may have been omitted. However, because insomnia is associated with various symptoms, researchers included cases in which insomnia was used as a sub-diagnosis because of differences in the severity of the symptoms in analysis of comorbidities. Second, researchers could not analyze clinical manifestations of insomnia (e.g., difficulty of sleep initiation or maintenance) because researchers used claims data. Furthermore, the degree of impact of insomnia on patients’ lives was not examined using scales such as the Insomnia Severity Index or Pittsburgh Sleep Quality Index. Additional studies are needed to investigate varying trends in healthcare utilization according to clinical manifestations and severity of insomnia. Third, it is possible that non-covered treatments such as herbal medicine and chuna therapy were omitted. Moreover, researchers could not compute the frequency and cost of CBT-I in this study because insurance coverage of CBT-I, which is specifically performed at the neuropsychiatry clinics in WM, was not available during the study period. Subsequent studies should also examine non-covered categories. Fourth, the study included repeated cross-sectional data that enable the analysis of follow-up care over a period of 1 year, but the data lacked yearly continuity. Cohort studies are needed for the long-term analysis of follow-up care. Finally, researchers analyzed sample data but could not perform an in-depth analysis of psychotherapies performed in KM facilities owing to the smaller number of psychotherapies performed relative to that in WM facilities. This is attributable to the smaller number of KM psychiatrists and the narrower scope of sleep disorder-related psychotherapies that can be performed by KM neuropsychiatrists, thus calling for relevant policy measures.

This entry is adapted from the peer-reviewed paper 10.3390/healthcare10010007

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