Post-Traumatic Stress Disorder in Caregivers: History
Please note this is an old version of this entry, which may differ significantly from the current revision.
Subjects: Psychiatry

Post-traumatic stress disorder (PTSD) is a mental disorder typically occurring after the exposure, both direct and indirect, to a traumatic event, and is characterized by the onset and persistence of a series of clinical symptoms that can often be profoundly incapacitating and tendentially chronic. In the past decades, increasing attention has been deserved to PTSD among caregivers of patients affected by severe medical conditions characterized by a risk for life, a severe impairment or a chronic course (e.g. cancer, severe injuries, type 1 diabetes and neurologic disorders) highlighting the potential traumatic role of such experiences.

  • Post-Traumatic Stress Disorder (PTSD)
  • Caregiver
  • mental health burden
  • carers
  • risk factors

1. Introduction

Caregiving burden is defined as the physical, psychological, social, or economic strain that caregivers may experience during the care of a loved one [1][2]. Caregivers are often overwhelmed in the early period of critical illness such that they struggle to understand even basic information about their loved one’s diagnosis, treatment, or prognosis [3]. Additionally, the role of family caregiver can be extremely stressful and result in many adverse outcomes, ranging from mild psychological stress to an increased risk of death [4]. Indeed, family caregivers, while struggling to adjust to new responsibilities and roles [5], may experience negative psychological outcomes that include new or worsening depression, anxiety, and Post-Traumatic Stress Disorder (PTSD) symptoms [6]. Furthermore, the prevalence of psychiatric disorders in caregivers can be associated to psychological symptoms in the patient [7][8][9], virtually worsening the patient outcome.

Increasing evidence on psychiatric consequences on caregivers of patients with mental disorders are available, some of which is on PTSD [10][11][12][13][14][15][16][17], however less data are available on caregiving burden of patients affected by severe somatic illnesses, mostly reporting on anxiety or depressive symptoms [18][19][20][21]. However, in a public health perspective it is extremely relevant to investigate PTSD in such population. PTSD, in fact, is usually related to reduced quality of life, increased risk of other psychopathological conditions [22][23][24][25][26], substance abuse [27], and considerable costs for healthcare systems [28]. These data were also confirmed by the Authors of the European Study of the Epidemiology of Mental Disorders Survey (ESEMeD), who reported that this kind of traumatic event largely contributed to the European 12 months PTSD prevalence [29].

2. Risk Factors for PTSD.

For what concerns the risk factors for PTSD in caregivers, studies highlighted the role of sociodemographic and socioeconomic characteristics; familiar relationships; illness-related distress; exposure characteristics; and psychiatric symptoms and negative/maladaptive coping.

Sociodemographic and socioeconomic characteristics. Females resulted to be more affected by PTSD symptoms in many studies [30][31][32][33][34][35][36][37][38]. Younger caregivers also seemed to suffer from higher PTSD symptoms in three studies [39][40][41]. Other studies reported lower income as risk factor for developing PTSD symptoms [30][42]. Another study on 151 partners of patients coping with an acute coronary syndrome found that a lower level of education was associated to higher PTSD symptoms [43], and similar results emerged from another study [31]. Only one study on 103 family caregivers of neurologic intensive care unit (neuroICU) patients reported an association between being not married nor cohabitating and higher PTSD symptoms [36]. Andresen et al. [32] in a sample of 83 close relatives of ICU patients, found that older patient’s age was associated to higher PTSD symptoms in relatives. This trend was shown up to patient’s age of 62 years old, and then there was no more increase. Conversely, Hartog et al. [33], examining 84 relatives of ICU patients, found that younger patient’s age was associated with higher PTSD symptoms.

Familiar relationships. Having a closer relationship with patients (i.e., being spouse or parent) was a factor related to PTSD symptoms in a study on 163 family caregivers of adult patients with acute leukemia [44]. Another study on 31 spouses and 25 close relatives of hospitalized patients with acute burns found that spouses had significantly higher levels of PTSD symptoms than close relatives [36]. Similarly, Hartog et al. [33] found that spouses were more prone to have higher PTSD symptoms in comparison to children and other relatives. Some other studies have examined the role of family relationships. Two studies have shown that having a lower bond or a poor relationship with the patient increased the risk of developing PTSD symptoms in the caregivers [40][45]. Teixeira and Pereira [34], analyzing a sample of 214 adult children caregivers of cancer patients, found that having a more enmeshed and chaotic family functioning predicted higher PTSD symptoms.

Illness-related distress. Many disease-related factors have been found to enhance PTSD symptoms. The uncertainty related to disease and the family strain have been related to PTSD symptoms in a study on 333 caregivers of hematopoietic cell transplant recipients [46]. Richardson et al. [47] found that in 78 caregivers of patients with head and neck cancer, having perceptions of low benefits from treatment and the presence of many patient symptoms, increased the risk of experiencing symptoms of PTSD in caregivers. Another study on 214 adult children caregivers of cancer patients highlighted that the perception of higher patient dependency was associated to higher PTSD symptoms [48]. Similarly, caregiving burden and caregiving strain have been stressed as a potential risk factors for PTSD in other studies [40][49][50]. Rumpold et al. [49] in a prospective study on 80 family caregivers of advanced cancer patients, found that caregiver subjective burden at baseline was significantly associated with PTSD symptoms at 9 months follow-up. Another study on 36 caregivers of ICU patients found that caregiving strain, represented by emotional adjustment, social issues, and physical and financial strain, was associated to increased PTSD symptoms [50]. Some authors [32], investigating a sample of 83 close relatives of ICU patients, found a relationship between patient’s Acute Physiology and Chronic Health Evaluation (APACHE) II score, an ICU scoring system used to classify the severity of disease, and PTSD symptoms in caregivers. Indeed, when the patient’s APACHE II score rose from 7 to 20, there was an increase in PTSD symptoms in caregivers, even though afterward the trend flattened. Other studies found an association between a greater severity of the disease [31], more days of hospitalization [32], persistent patient’s pain [42], and the levels of PTSD symptoms. Another study on 82 family members of ICU patients found that being caregivers of ICU patients with a traumatic brain injury (TBI), rather than of ICU patients without TBI, was a risk factor for experiencing more PTSD symptoms [51]. Furthermore, Dew et al. [40] examined 190 family caregivers to heart transplant recipients and found that in the first year post-transplant, caregivers presented higher PTSD symptoms. A more recent study on informal caregivers of adult hematopoietic cell transplant recipients showed that a shorter time since transplant was associated with greater PTSD symptoms in caregivers [46]. Moreover, Teixeira and Pereira [48] found that a shorter disease and caregiving duration were associated with a poorer outcome in terms of PTSD symptomatology, while Carek et al. [41], examining 51 caregivers of recent stroke survivors, found that an increased time since the event, with consequently more chronic stressors related to the sequelae of the medical event, was related to higher PTSD symptoms. Finally, Norup and Elklit [31] found that also the subjective evaluation of severity of illness may have enhanced PTSD symptoms.

Exposure characteristics. In a study on 41 family members of patients in the neuroICU, researchers found that having had more frequent visits in the aftermath of the event, which implied more time spent at bedside, was related to greater PTSD symptoms [42]. Having accompanied the patient during the drive to the Intensive Cardiac Care Unit (ICCU) after witnessing the medical event also was found to be a risk factor for PTSD, in a study on 143 female partners of acute coronary event patients [52]. Finally, in a prospective study on 102 relatives of patients with chronic obstructive pulmonary disease who survived an ICU stay, peritraumatic dissociation was related to higher PTSD symptoms at 90 days post-discharge [53].

Psychiatric symptoms and negative/maladaptive coping. Alfheim et al. [39], analyzing a sample of 211 family caregivers of ICU patients, found that having more comorbidities, such as depression or pain, was predictive of having more PTSD symptoms. Presenting higher levels of anxiety [45][54], depression [53], or both depression and anxiety symptoms [31][35] were all found to be related to a higher severity of PTSD symptoms. As concerns the prior psychiatric history, having a history of depression [35][37], depressive and anxiety disorders [40], or more generically a personal positive history for psychiatric illness [30] were associated with increased PTSD symptoms. Even the presence of psychiatric symptoms in patients was found to be a risk factor for some authors, particularly patient’s PTSD symptoms in three studies [44][46][55] and panic disorder symptoms in another study on 168 caregivers of advanced cancer patients [56]. Negative coping styles have been related to greater PTSD symptoms severity in a study on 86 family members and friends of patients who have suffered spontaneous subarachnoid hemorrhage [57]. Another two studies have highlighted the importance of maladaptive coping strategies, such as avoidance, denial, behavioral disengagement and use of humor, in predicting caregivers’ PTSD symptoms [40][47]. Finally, a study on 101 relatives of out-of-hospital cardiac arrest patients found that caregivers’ perception of patient’s therapy as insufficient was related to higher PTSD symptoms [37].

3. Protective Factors for PTSD.

Social status, familiar relationships, support, and positive coping resulted the most important factors related to lower PTSD symptoms in caregivers of severely ill adult patients.

Social status. Alfheim et al. [39] found that being on sick leave was a risk factor for PTSD and suggested that continuing to work reduced PTSD symptoms in caregivers. Also having higher educational levels was associated with fewer PTSD symptoms [32].

Familiar relationships. Being the parent of the patient, instead of the spouse or a friend [39] was found to be related to a better outcome in PTSD symptoms. Moreover, Stukas et al. [30], examining a sample of 142 family caregivers of heart transplant recipients, found that having a higher level of family cohesiveness reduced PTSD symptomatology.

Support. The importance of support has been highlighted by many studies [30][31][35][44][48][58]. Norup and Elklit [31], examining 614 partners of people with epilepsy, found that a high level of social support decreased PTSD symptoms, and similar findings were highlighted in another study on 39 partners of head and neck cancer survivors [35]. Another study on 306 surrogate decision makers of patients with chronic critical illness found that perceptions of clinician support and communication reduced PTSD symptoms [58].

Positive coping. A positive coping style [36] and mindfulness [36][45] were both shown to reduce PTSD symptoms. Indeed, Choi et al. [45], on a sample of 99 caregivers of patients admitted to a neuroICU, found that caregivers with higher levels of mindfulness were more likely to have lower PTSD symptoms. Having feelings of hope [39] or a perceived sense of mastery in the situation [40] were also associated with a reduction in PTSD symptoms.

Table 1. Characteristics of included studies.

Study

Year

Study Type

Sample

Quality Rating

Assessments

PTSD Rates

Risk Factors

Protective Factors

Alfheim et al. [39]

2018

Longitudinal

211 family caregivers of intensive care unit patients

Good

IES-r

PTSD: 54% (at enrolment); 24% (at 12 months)

-Younger

-Having more comorbidities (e.g., pain, depression.)

-Being on sick leave

-Being the parent

of the patient (than spouse or friend)

-Increased levels of hope

-Working

Andresen et al. [32]

2015

Prospective

83 caregivers of ICU patients assessed at admission (time I), at 2 to 4 days (time II) and 60 days (time III).

Fair

PCLS

PTSD: 22.89%

-Older patient’s age, up to 62 years old

-Greater severity of disease from APACHE II level of 7 up to 20

-More days of hospitalization

-Female

-Educational level

Bambauer et al. [56]

2006

Longitudinal

168 patient–caregiver dyads (Advanced cancer patients and their primary, informal, non-paid caregivers)

Fair

SCID IV

PTSD: 4.17%

-Patient psychiatric disorders

 

Bond et al. [38]

2017

Prospective

31 spouses and 25 close relatives of hospitalized patients with acute burns

Good

Modified PTSD Symptom Scale

PTSD: 23.21% at admission, 8.33% at discharge

-Women

-Spouses

 

Carek et al. [41]

2010

Cross-sectional

51 informal caregivers of recent stroke survivors

Poor

PDS; PTCI

PTSD: 20%

-Younger

-Increased time since stroke

 

Choi et al. [45]

2018

Prospective, observational

99 caregivers of patients admitted to neuroICU assessed during admission (baseline), three months, and six months post-hospitalization

Good

PCLS

PTSD: 16% (baseline); 22% (at six months)

-Fearful/anxious profile during admission

-Negative relationship with patient

-Strong positive relationship with patient

-Mindfulness

Cornelius et al. [52]

2020

Longitudinal

143 female partners of acute coronary event patients four months after the event

Fair

PDS-5

PTSD symptoms: 74.1%

-Accompanying the patients during the drive to the hospital, than only witnessing the emergence of symptoms.

 

De Miranda et al. [53]

2011

Prospective multicenter

102 informal caregivers of patients with

chronic obstructive pulmonary disease

Fair

IES

PTSD: 29.8% (on day 90)

-Peritraumatic dissociation at ICU discharge

-Depressive symptoms

 

Dew et al. [40]

2004

Prospective

190 caregivers to heart transplant recipients evaluated at 2, 7, 12, and 36 months post-transplant

Good

CIDI

PTSD-T: 22.5% (cumulative rates 3 years post-transplant)

-Younger

-Lower bond with patient

-Caregiver burden

-First year post-transplant

-History of depressive and anxiety disorders

-Maladaptive coping

-Higher sense of mastery

Fait et al. [43]

2016

Cross-sectional

151 partners of patients with acute coronary syndrome 2 to 6 months after patients’ hospitalization

Poor

PC-PTSD

CDI-PTSD symptoms: 11%

-Lower level of education

 

Hartog et al. [33]

2015

Prospective observational

84 relatives od ICU patients interviewed by phone after 90 days

after patients had died or were discharged

Fair

IES

PTSD: 51%

-Younger patient age

-Female

-Spouses (with respect to children and other relatives)

 

Jia et al. [44]

2015

Cross-sectional

163 caregivers of adult patients with acute leukemia

Poor

PCL-C

PTSD symptoms: 36.8%

-Closer relationship

with patients (e.g., spouses)

-Higher levels of patients’ PTSS

-Higher levels of perceived social support

Liang et al. [46]

2019

Cross-sectional

333 caregivers of adult hematopoietic cell transplant recipients

Poor

PCL-5

PTSD: 6.6%

-Shorter time since hematopoietic cell transplant.

-PTSD in patient

-Higher cancer-related distress

 

McPeake et al. [50]

2016

Cross-sectional

36 caregivers of ICU patients

Poor

IES

PTSD:53%

-Caregiving strain

 

Meyers et al. [36]

2020

Longitudinal prospective cohort

103 family caregivers of neuroICU patients at baseline and 3- and 6-month follow-up

Good

PCL-Specific Stressors

PTSD symptoms: 16% baseline; 14% at 6 months

-Female

-Not married/cohabitating

-Higher baseline mindfulness

-Positive coping

Moschopoulou et al. [35]

2018

Cross-sectional

39 partners of head and neck cancer survivors

Fair

PCL-C

PTSD: 12.8%;

PTSD symptoms: 25.7%

-Prior history of depression

-Female

-Symptoms of depression and anxiety

-Social support

Noble and Schenk [57]

2008

Cross-sectional

86 family members

and friends of patients with

spontaneous subarachnoid hemorrhage

Fair

PDS

PTSD: 25.6%

-Maladaptive

coping strategies

 

Norup and Elklit [31]

2013

Cross-sectional

614 partners of people with epilepsy

Poor

HTQ

full PTSD: 7.7%;

partial PTSD: 43.9%

-Female

-Less years of education

-Objective and subjective epilepsy severity

-Anxiety and depression

-Social support

Richardson et al. [47]

2016

Prospective

78 caregivers of patients

with head and neck cancer at diagnosis and 48 caregivers

six months later

Good

PSSSR

PTSD: 19%

-Perceived little benefit from treatment

-Many cancer

symptoms

-Denial and/or behavioral disengagement

at diagnosis

-Use of humor at diagnosis

Rumpold et al. [49]

2016

Prospective

80 family caregivers of advanced cancer patients at baseline and at 9 months follow-up

Good

IES-r

PTSD: 19.5% (baseline); 12.5% (follow-up)

-Caregiver subjective burden

 

Stukas et al. [30]

1999

Prospective

142 family caregivers of heart transplant recipients

Good

CIDI

PTSD: 7.7%

-Female

-Younger

-Lower income

-Personal history of psychiatric disorder

-Lower friend support

-Higher family cohesiveness

Sundararajan et al. [54]

2014

Cross-sectional

63 family members of ICU patients

Fair

IES-r

PTSD symptoms: 41.2%

-Anxiety symptoms

 

Teixeira and Pereira [48]

2012

Cross-sectional

214 adult children caregivers of parents with cancer

Poor

IES-r

Not reported

-Female

-Perception of higher parental dependency

-Shorter disease and caregiving’s duration

-Social support

Teixeira and Pereira [34]

2016

Cross-sectional, comparative

214 adult children caregivers of cancer patients and 78

adult children of nonchronically ill parents

Poor

IES-r

Not reported

-Female

-Enmeshed or chaotic family functioning

 

Trevick and Lord [42]

2017

Prospective cohort

41 caregivers of neuroICU patients at baseline, 26 at 1 month and 23 at 6 months

Fair

IES-r

PTSD: 7.7% at 1 month and 17% at 6 months

-Lower income

-More frequent visits at 1 month

-Persistent pain at 6 months

 

Warren et al. [51]

2016

Longitudinal

40 family members of ICU patients with traumatic brain injury (TBI) and 42 of non-TBI ICU patients, assessed at baseline and 3 months

Good

PC-PTSD

PTSD symptoms: 24.3%

-ICU patients with TBI vs. ICU patients without TBI

 

Wendlandt et al. [58]

2019

Randomized controlled

306 surrogate decision makers of patients with chronic critical illness 90 days post-randomization

Good

IES-r

Not reported

 

-Support and communication

Wintermann et al. [55]

2019

Cross-sectional

70 partners of chronically critically ill patients

Fair

PTSS-10

PTSD symptoms:18.6%

-Patient’s PTSS

 

Zimmerli et al. [37]

2014

Observational

101 relatives of out-of-hospital cardiac arrest patients

Good

IES-r

PTSD: 40%

-Females

-History of depression

-Family perception of patient’s therapy as insufficient

 

APACHE II, Acute Physiology And Chronic Health Evaluation II; CIDI, Composite International Diagnostic Instrument; HTQ, Harvard Trauma Questionnaire; ICU, Intensive Care Unit; IES, Impact of Event Scale; IES-r, Impact of Event Scale-Revised; PCL-5, PTSD Checklist for the Diagnostic and Statistical Manual of Mental Disorders 5th edition; PCL-C, PTSD Checklist-Civilian Version; PCLS, Post-traumatic stress disorder checklist, version S; PC-PTSD, Primary care-PTSD screening questionnaire; PDS, Post-traumatic Diagnostic Scale; PDS-5, Post-traumatic Diagnostic Scale for DSM-5; PSSSR, Post-Traumatic Stress Disorder Symptom Scale; PTCI, Post-traumatic Cognitions Inventory; PTSD, Post-Traumatic Stress Disorder; PTSD-T, Post-Traumatic Stress Disorder related to the Transplant; PTSS, Post-Traumatic Stress Symptoms; PTSS-10, Post-traumatic Stress Scale; SCID-IV, Structured Clinical Interview for DSM-IV.

This entry is adapted from the peer-reviewed paper 10.3390/ijerph17165888

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