Alkylation chemistry comprises reactions that form a bond between an alkyl fragment and a nucleophilic atom or carbon centre. In its classical organic-chemical sense, an electron-rich substrate displaces a leaving group from, or otherwise reacts with, an alkylating agent; the outcome is governed by the structures and electronic properties of both partners and by the reaction mechanism. The term therefore encompasses carbon alkylation as well as N-, O-, S-, and related heteroatom alkylations. Alkylation is distinguished from arylation by transfer of an alkyl, rather than an aryl, group, and its mechanistic description commonly involves polar substitution or addition pathways ^[1]. O-Alkylation is a defined subclass in which an oxygen nucleophile becomes bonded to the transferred alkyl group ^[2].