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Solvent Extraction: History
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Contributor: Yu Peng

Solvent extraction is an analytical separation process in which a chemical species is transferred from a sample phase into a contacting solvent phase according to its relative solubility, chemical form, and distribution between the phases [1][2]. The process generally involves contacting the sample with an immiscible or partially miscible extractant, allowing the target analyte to partition between the phases, promoting phase separation, and collecting the phase enriched in the analyte for subsequent measurement [1][3]. Extraction behavior is governed by the distribution coefficient or distribution ratio of the analyte and is influenced by solvent composition, polarity, pH, ionic strength, temperature, phase-volume ratio, contact time, mixing, and the chemical interactions governing analyte solvation or complex formation [1][4]. In analytical chemistry, solvent extraction includes batch liquid–liquid extraction, continuous extraction, dispersive liquid–liquid microextraction, and related miniaturized liquid-phase procedures in which the extracting solvent functions as the phase responsible for analyte isolation and, frequently, preconcentration [2][4][5]. The concept encompasses extraction of inorganic, organic, and biochemical analytes from liquid or dissolved sample matrices, together with optimization and quantitative assessment of recovery, selectivity, enrichment, and phase-transfer efficiency [1][2][3][4][5].

  • Liquid-liquid distribution
  • distribution constant
  • Nernst partition law
  • preconcentration
  • phase equilibrium

References

  1. N. M. Rice; H. M. N. H. Irving; M. A. Leonard; Nomenclature for liquid-liquid distribution (solvent extraction) (IUPAC Recommendations 1993). Pure Appl. Chem. 1993, 65, 2373-2396, 10.1351/pac199365112373.
  2. Gregory Choppin; Claude Musikas; Tatsuya Sekine; Jan Rydberg. Solvent Extraction Equilibria; Taylor & Francis: London, United Kingdom, 2004. [CrossRef]
  3. Ying Zhang; Meng Chen; Linsen Li; Yueguang Lv; Qiang Ma; Recent advances in microextraction techniques using sustainable green solvents for mass spectrometry analysis. TrAC Trends Anal. Chem. 2023, 170, 117412, 10.1016/j.trac.2023.117412.
  4. Hakim Faraji; Advancements in overcoming challenges in dispersive liquid-liquid microextraction: An overview of advanced strategies. TrAC Trends Anal. Chem. 2023, 170, 117429, 10.1016/j.trac.2023.117429.
  5. Cristina I.C. Silvestre; João L.M. Santos; José L.F.C. Lima; Elias A.G. Zagatto; Liquid–liquid extraction in flow analysis: A critical review. Anal. Chim. Acta 2009, 652, 54-65, 10.1016/j.aca.2009.05.042.
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