Conversion of neutral atoms or molecules into ions, followed by optical or mass-spectrometric readout of those ions, is the defining sequence of ionization spectrometry. In laser-enhanced ionization and resonant ionization, tuned lasers promote atoms to excited states that are more readily ionized in a flame or vacuum, and the resulting ions or the ionization current are measured [1]. Laser desorption coupled to resonant ionization separates the desorption event from a subsequent wavelength-selective ionization step [2]. Surface-enhanced laser desorption/ionization records ions generated at a chemically modified surface, which is a desorption-ionization variant of the same ion-production concept [3]. Conceptual boundaries exclude purely photonic absorption or emission spectrometry that does not produce ions, and they exclude mass spectrometry named only by its analyzer when the ionization step is not the defining object. Essential features are a defined ionization mechanism, a population of ions whose number or mass-to-charge ratio is the analytical signal, and an optical or mass-selective observation of that population [4].
- ionization spectrometry
- resonant ionization
- laser-enhanced ionization
- ion production
Metabolomics and Mass Spectrometry Studies • Molecular Biology • Biochemistry, Genetics and Molecular Biology • Life Sciences
References
- Alexander A. Gorbatenko; Timur A. Labutin; Andrey M. Popov; Nikita B. Zorov; Reduction of the matrix influence on analytical signal in laser-enhanced ionization spectrometry with laser sampling. Talanta 2006, 69, 1046-1048, 10.1016/j.talanta.2005.12.009.
- J. M. Orea; C. Montero; J. B. Jiménez; A. González Ureña; Analysis oftrans-Resveratrol by Laser Desorption Coupled with Resonant Ionization Spectrometry. Application totrans-Resveratrol Content in Vine Leaves and Grape Skin. Anal. Chem. 2001, 73, 5921-5929, 10.1021/ac010439p.
- Cloud P. Paweletz; Matthew C. Wiener; Jeffrey R. Sachs; Roger Meurer; Margaret S. Wu; Kenney K. Wong; Nathan A. Yates; Ronald C. Hendrickson; Surface enhanced laser desorption ionization spectrometry reveals biomarkers for drug treatment but not dose. Proteom. 2006, 6, 2101-2107, 10.1002/pmic.200500569.
- Summer L. Ziegler; Bruce A. Bushaw; Ultratrace Uranium Fingerprinting with Isotope Selective Laser Ionization Spectrometry. Anal. Chem. 2008, 80, 6029-6033, 10.1021/ac800764j.