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Extraction Chromatography: History
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Contributor: Helena Kang

An extractant dissolved or impregnated in a porous inert support, rather than a covalently bonded ion-exchange group, constitutes the stationary phase of extraction chromatography. The mobile phase is typically an aqueous acid or salt solution; the target ion or molecule partitions into the supported organic extractant according to the same equilibria that govern liquid–liquid extraction, and is later stripped by a change of aqueous composition [1]. Crown ethers, organophosphorus acids, and related extractants provide selective coordination environments for strontium, actinides, and other species [2]. The technique is thereby a chromatographic embodiment of solvent extraction, distinct from solid-phase extraction that uses a dry sorbent without a liquid extractant film, and from reversed-phase chromatography whose retention is not based on a designed extractant–metal or extractant–solute complex [3]. Essential features are a defined extractant, a support that holds that extractant without dominating selectivity, and a reversible partition that can be reset by the aqueous eluent. Conceptual boundaries also exclude ordinary adsorption chromatography on bare silica or alumina.

  • extraction chromatography
  • supported extractant
  • partition
  • radiochemical separation

Chromatography in Natural Products • Analytical Chemistry • Chemistry • Physical Sciences

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