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Inorganic Acid Catalysis: History
Please note this is an old version of this entry, which may differ significantly from the current revision.
Subjects: Chemistry, Organic
Contributor: Helena Kang

Inorganic acid catalysis is acceleration of a reaction by an inorganic Brønsted acid, such as sulfuric, hydrochloric, phosphoric, perchloric, or a heteropolyacid, with regeneration of the acid after product formation. The central elementary step is reversible proton transfer from the acid or its solvated form to a substrate. Protonation can increase carbonyl electrophilicity, convert a hydroxy group into a better leaving group, or generate a carbocationic intermediate; subsequent bond formation or cleavage and deprotonation complete turnover. Silica–sulfuric acid and alumina–sulfuric acid retain Brønsted acidity while operating as supported heterogeneous catalysts [1]. Sulfonic-acid-functionalized mesoporous silica represents a related solid-acid class used in organic reactions [2]. The term is defined by the inorganic proton donor, not simply by low pH. It therefore excludes Lewis-acid catalysis by electron-pair-accepting metal centers when no proton transfer is involved, and it differs from organic Brønsted-acid catalysis by carboxylic, sulfonic, or chiral phosphoric acids.

  • inorganic acid catalysis
  • mineral acids
  • Brønsted acid catalysis
  • protonation

Synthesis and Catalytic Reactions • Organic Chemistry • Chemistry • Physical Sciences

References

  1. Amit Pramanik; Sanjay Bhar; Silica–sulfuric acid and alumina–sulfuric acid: versatile supported Brønsted acid catalysts. New J. Chem. 2021, 45, 16355-16388, 10.1039/d1nj02887a.
  2. Ghodsi Mohammadi Ziarani; Negar Lashgari; Alireza Badiei; Sulfonic acid-functionalized mesoporous silica (SBA-Pr-SO3H) as solid acid catalyst in organic reactions. J. Mol. Catal. A: Chem. 2015, 397, 166-191, 10.1016/j.molcata.2014.10.009.
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