Encyclopedia
brain derived neurotrophic factor
- genes
1. Normal Function
The BDNF gene provides instructions for making a protein found in the brain and spinal cord called brain-derived neurotrophic factor. This protein promotes the survival of nerve cells (neurons) by playing a role in the growth, maturation (differentiation), and maintenance of these cells. In the brain, the BDNF protein is active at the connections between nerve cells (synapses), where cell-to-cell communication occurs. The synapses can change and adapt over time in response to experience, a characteristic called synaptic plasticity. The BDNF protein helps regulate synaptic plasticity, which is important for learning and memory.
The BDNF protein is found in regions of the brain that control eating, drinking, and body weight; the protein likely contributes to the management of these functions.
2. Health Conditions Related to Genetic Changes
2.1. Opioid Addiction
Opioid addiction
2.2. WAGR Syndrome
The BDNF gene is located in a region of chromosome 11 that is often deleted in a condition known as WAGRO syndrome. This condition is a variant of WAGR syndrome, which is a disorder that affects many body systems and is named for its main features: a childhood kidney cancer known as Wilms tumor, an eye problem called anirida, genitourinary anomalies, and intellectual disability (formerly referred to as mental retardation). WAGRO syndrome also includes obesity. The deletions that cause WAGRO syndrome remove many genes from one copy of chromosome 11, including part or all of the BDNF gene. The loss of this gene is responsible for weight gain that begins in childhood in people with WAGRO syndrome.
People with WAGRO syndrome may be at greater risk of neurological problems such as intellectual disability and a developmental disorder called autism spectrum disorder that affects communication and social interaction than those with WAGR syndrome. It is unclear whether this increased risk is due to the loss of the BDNF gene or other nearby genes.
2.3. Other Disorders
Certain common genetic variations (polymorphisms) in the BDNF gene have been associated with an increased risk of developing psychiatric disorders such as bipolar disorder, anxiety, and eating disorders.
Most studies have focused on the effects of a particular polymorphism in the BDNF gene. This variation alters a single protein building block (amino acid) in the protein, replacing the amino acid valine with the amino acid methionine at position 66 (written at Val66Met or V66M). This change impairs the protein's ability to function. Many studies report an association between the Val66Met polymorphism and psychiatric disorders; however, some studies have not supported these findings. It is unclear how changes in the BDNF gene are related to these disorders. A large number of genetic and environmental factors, most of which remain unknown, likely determine the risk of developing these complex conditions.
3. Other Names for This Gene
- abrineurin
- ANON2
- BDNF_HUMAN
- brain-derived neurotrophic factor
- BULN2
- neurotrophin
This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/gene/bdnf
References
- Han JC, Liu QR, Jones M, Levinn RL, Menzie CM, Jefferson-George KS,Adler-Wailes DC, Sanford EL, Lacbawan FL, Uhl GR, Rennert OM, Yanovski JA.Brain-derived neurotrophic factor and obesity in the WAGR syndrome. N Engl J Med.2008 Aug 28;359(9):918-27. doi: 10.1056/NEJMoa0801119. Erratum in: N Engl J Med. 2008 Sep 25;359(13):1414.
- Rodríguez-López R, Pérez JM, Balsera AM, Rodríguez GG, Moreno TH, García deCáceres M, Serrano MG, Freijo FC, Ruiz JR, Angueira FB, Pérez PM, Estévez MN,Gómez EG. The modifier effect of the BDNF gene in the phenotype of the WAGROsyndrome. Gene. 2013 Mar 10;516(2):285-90. doi: 10.1016/j.gene.2012.11.073.
- Sears C, Markie D, Olds R, Fitches A. Evidence of associations between bipolardisorder and the brain-derived neurotrophic factor (BDNF) gene. Bipolar Disord.2011 Nov-Dec;13(7-8):630-7. doi: 10.1111/j.1399-5618.2011.00955.x.
- Shinawi M, Sahoo T, Maranda B, Skinner SA, Skinner C, Chinault C, Zascavage R,Peters SU, Patel A, Stevenson RE, Beaudet AL. 11p14.1 microdeletions associatedwith ADHD, autism, developmental delay, and obesity. Am J Med Genet A. 2011Jun;155A(6):1272-80. doi: 10.1002/ajmg.a.33878.
