Kynurenine Pathway: History
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Tryptophan metabolism plays an essential role in human health. In mammals, about 95% of dietary tryptophan is metabolized through the kynurenine pathway, which is associated with the development of several pathologies, including neurodegeneration. Some of the kynurenine pathway metabolites are agonists of the aryl hydrocarbon receptor involved in metabolic functions, inflammation, and carcinogenesis. 

  • tryptophan metabolites
  • kynurenine pathway
  • kynurenine

1. Introduction

Tryptophan (TRP) is an exogenous amino acid that cannot be synthesized in the human body. It must be delivered through nutritional sources and, in the organism, it is found bound to albumin or free form [1]. In the human organism, TRP is involved in the biosynthesis of protein and regulation of metabolic networks as it is a precursor for important biologically active compounds like coenzymes nicotinamide adenine dinucleotide (NAD+), and NAD phosphate (NADP+), serotonin, tryptamine, melatonin, niacin, kynurenine (KYN), and indole and indolic acid derivatives [2][3]. Its concentration in the body is lower than that of other amino acids and it might play a rate-limiting role in protein synthesis [4]. The gut microbiota utilizes ~4–6% of TRP for the production of indole, indican, tryptamine, skatole, and indole acid derivatives [5]. In the mammal’s brain, TRP is metabolized to serotonin (5-hydroxytryptamine)—a neurotransmitter that modulates neural activity and a wide range of neuropsychological processes like mood, perception, reward, anger, aggression, appetite, memory, sexuality, and attention [6]. In the pineal gland, serotonin serves as a precursor for the synthesis of melatonin, which is involved in the regulation of circadian rhythm, and the reproductive and immune systems [7]. Approximately, 3% of dietary TRP is utilized for serotonin synthesis throughout the body (1% is utilized in the brain) [8]. Alternatively, TRP might be converted to a trace amount of tryptamine—an important neuromodulator of serotonin [3]. About 95% of intake TRP is metabolized via the kynurenine pathway (KP), producing KYN and other derivatives [9]. KYN secretion by different cells plays an important role in immune privilege during infections, inflammations, pregnancy, and cancer. The contributions of the different metabolic pathways of TRP utilization may differ under physiological and pathological statuses.
Both excessive intake and deficiency of TRP can unbalance its homeostasis and affect human health [4]. The impact of TRP supplementation on human health has so far been studied mainly in terms of serotonin pathway activation. The benefits of TRP loading on human cognition, mood, and sleep as a result of serotonergic stimulation have been widely reported [10]. The KP is the main metabolic route of this amino acid. Moreover, food might contain KP metabolites itself, which has been confirmed by many studies [11][12][13][14][15][16][17][18][19]. Some of them are essential for the proper functioning of the body and have a beneficial effect, e.g., kynurenic acid (KYNA) or nicotinamideadenine dinucleotide. On the other hand, KP delivers some metabolites which could exert cytotoxic (e.g., KYN, 3-hydroxyanthranilic acid (3HAA), and 3-hydroxykynurenine (3HKyn)) and neurotoxic (e.g., quinolinic acid (QA)) impacts. Notably, elevated levels of some KP metabolites are associated with various diseases, e.g., increased KYN and KYNA are connected with inflammatory bowel disease [20] and ulcerative colitis [21], respectively. Providing compounds from KP with food can positively or negatively affect human health. 

2. Kynurenine Pathway—An Overview

In mammals, KP (Figure 1) is initiated through the activity of the enzymes: indoleamine-2,3-dioxygenases (IDO1 and IDO2) or tryptophan-2,3-dioxygenase (TDO). TDO acts mainly in the liver, while IDO has a wide tissue and cellular distribution. As a result of this reaction, N-formylkynurenine (NFK) is formed which is instantaneously converted by NFK formamidase to L-KYN—the first stable KP metabolite [22]. Degradation of L-KYN proceeds in three ways: (1) enzymes family of kynurenine aminotransferase (KAT) leads to the production of KYNA; (2) L-KYN can be hydrolyzed by kynureninase to anthranilic acid (AA); and (3) kynurenine mono-oxygenase (KMO) can lead to hydroxylation of L-KYN resulting in 3HKyn formation. The activity of some KP enzymes (IDO and KMO) is also upregulated by immune stimulation [23]. Further transformation of 3HKyn is accomplished by kynureninase and causes 3HAA formation [24]. The next product, 2-amino-3-carboxymuconic 6-semialdehyde (ACMS), is formed as a result of 3-hydroxyanthranilate-3,4-dioxygenase action. This unstable metabolite can be converted in two different ways: (1) preferably via QA, which, subsequently, undergoes the transformation and leads to the production of the essential redox cofactor nicotinamideadenine dinucleotide (NAD+) and (2) less efficiently 2-amino-3-muconic acid-6-semialdehyde (AMS), which, subsequently, generates picolinic acid (PIC) resulting from non-enzymatic cyclization or it is metabolized to acetyl CoA [22][25]. Alternatively, the transamination of 3HKyn by KAT leads to xanthurenic acid (XA) formation, whereas the dimerization of 3HAA produces cinnabarinic acid (CA) [23].
Figure 1. Schematic overview of TRP metabolism via KP in mammals. Abbreviations: ACMSD—2-amino-3-carboxymuconic acid semialdehyde decarboxylase; FAM—N′-formylkynurenineformamidase; 3-HAAO—3-hydroxyanthranilic acid 3,4-dioxygenase; IDO1—indoleamine-2,3-dioxygenase 1; IDO1—indoleamine-2,3-dioxygenase 2; KAT—kynurenine aminotransferase; KMO—kynurenine mono-oxygenase; KynA—kynureninase A; KynB—kynureninase B; QPR—quinolinate phosphoribosyl transferase; and TDO—tryptophan-2,3-dioxygenase.

3. Circulation of KP Metabolites

In the human body, approximately <1% of ingested TRP is utilized for protein synthesis. TRP is transported by large neutral amino acid transporters mainly into the gut, where it is metabolized by microbiota [5]. The rest enters portal circulation and undergoes liver metabolism [26]. Notably, about 75–95% of circulating TRP is bound to albumin, but only free TRP can cross the blood–brain barrier (BBB). The unbounded TRP can be further metabolized along four degradation pathways [3][26].
Gut microbiota modulates intestinal TRP metabolism. Commensal microbes can transform TRP into tryptamine (by tryptophan decarboxylases), indole and its derivatives (by tryptophanase), and serotonin (by tryptophan synthetase). However, the initiation of TRP degradation via KP occurs by the activation of Toll-like receptors (TLRs) by microbial components. Notably, butyrate—produced by gut microbes—suppresses KYN production by downregulation of intestinal IDO expression via various mechanisms [27].
More than 60% of KYN is directly transported from peripheral circulation to the brain, where it is transformed into other neuroactive compounds [28]. 3HKyn and AA also have the ability to cross BBB, while KYNA, 3HAA, and QA cross it very poorly [28][29][30]. Furthermore, KYN can cross the placenta and fetal blood–brain barrier [31].
In peripheral tissues (liver and kidney), phagocytes (monocytes and macrophages), and microglia cells, KMO predominantly break down KYN to 3HKyn, which is further cleavaged to 3HAA and QA, leading to NAD+ formation [23]. Alternatively, KYN can be hydrolyzed to AA—a precursor for QA production. In astrocytes, however, KAT is catalyzed to KYN and converted to KYNA. Furthermore, glial cells and neurons produce PIC [23].
After oral ingestion, KYN is absorbed into the intestine [28]. Also, KYNA can be easily absorbed from the lumen of the digestive system into the bloodstream and transported to the liver and the kidneys [32][33]. In blood, its concentration achieves the highest level 15–30 min after ingestion, and back to the basal level after 2 h [33]. After ingestion, a successive increase in KYNA level in bile, pancreatic juice, and intestinal lumen is observed [34]. Under normal conditions, the majority of KP metabolites are excreted in the urine [34][35][36]. The presence of some KP metabolites in faeces and sweat was also demonstrated [34][36].

4. Biological Functions of KP Metabolites

The role of KP is connected with many diseases and conditions. The metabolism of TRP is related to neuropsychiatric and cardiovascular diseases, inflammation, and cancer, and KP metabolites have various biological functions (Table 1).
Table 1. Comparison of positive and negative health effects of the KP metabolites.
KYN shows immudulatory properties, e.g., it inhibits T-cell proliferation, reduces the activity of natural killer cells and dendritic cells, and promotes the differentiation of regulatory T-cells [41][42][43]. This metabolite shows antimicrobial activity and was identified as a specific agonist of the human aryl hydrocarbon receptor (AhR) [38]. Upregulation of KYN was noted in the case of such pathologies as infections, autoimmunological diseases, and cancer [44]. An increasing ratio of KYN/TRP is associated with cardiovascular diseases such as coronary heart disease [45][46] and it can be considered a biomarker for irritable bowel syndrome. Of note, it was demonstrated in rats, that this KP metabolite mediates vasorelaxation and lower blood pressure in a dose-dependent manner [47]. Furthermore, KYN production in the human body also varies when neurological and psychiatric disorders occur [48].
From a therapeutic standpoint, KYNA is one of the most interesting metabolites [23]. It is mainly produced in glial cells. It is also a competitive antagonist of glutamate receptors—NMDA receptors, kainate receptors, and AMPA receptors. The additional targets of KYNA are the α7 nicotinic acetylcholine receptor (α7nAChR), the former orphan G protein-coupled receptor (GPR35), and AhR [29]. KYNA shows neuroprotective, antioxidant-free radical scavenging properties, reduces oxidative stress, and decreases protein and lipid damage [23]. There are strong indications that this TRP metabolite exerts anti-inflammatory or proinflammatory effects, depending on whether inflammatory or homeostatic conditions are considered [49]. It was demonstrated on human natural killer T-cells that activation of GPR35 by KYNA (300 µM) significantly reduces the release of IL-4 [50]. This KP metabolite of ~500 µM dose suppresses the production of IL-23 and IL-17 by dendritic cells [51]. KYNA inhibits TNF-α release from human mononuclear leukocytes [52]. It was also demonstrated that cancer cells in the intestine produce KYNA more effectively in comparison with normal colon epithelial cells, without overexpression of KATs in these cell lines [53]. The antiproliferative action of KYNA (>10 µM) against in vitro cultured colon cancer cells (HT-29, LS-180, and Caco-2) has also been reported [53]. On the other hand, KYNA could influence intestinal inflammation and hypermotility [54]. An increased ratio of KYNA/TRP is associated with endoscopic inflammation and is predictive of disease outcomes in ulcerative colitis patients [21]. A higher level of KYNA was also noted in patients with schizophrenia relative to healthy controls (when KYNA content was analyzed in cerebrospinal fluid, central nervous system, and brain tissue samples) [55]. On the other hand, a decrease in KYNA occurs in patients with Parkinson’s and Huntington’s diseases, and multiple sclerosis [29].
3Hkyn and 3HAA are both good electron donors and their oxidation results in the formation of a highly reactive quinoneimine [37]. Even the micromolar concentration of these compounds contributes to the generation of the reactive oxygen species (ROS)—hydroxyl radicals and hydrogen peroxides—and induces oxidative stress [56]. This pro-oxidant behavior would explain some toxical actions of 3HAA and 3HKyn [42][57][58]. In particular, they are T-cell-suppressive and have an additive effect in the presence of KYN [42]. Furthermore, a large body of literature has demonstrated in vitro neurotoxicity of 3Hkyn by ROS overproduction, direct protein interaction, and mitochondrial dysfunction [37]. On the contrary, many reports reveal the antioxidant function of both 3HAA and 3HKyn [37][57]. For example, these two metabolites of 20 µM dose effectively protected B-phycoerythrin from peroxyl radical-mediated oxidative damage [59]. Increasing 3HKyn and 3HAA can be related to neurodegenerative disorders—Huntington’s, Parkinson’s, and Alzheimer’s diseases. Another KP metabolite—AA—could be considered a biological marker in schizophrenia [60] or gastric cancer patients [61]. Although AA is not efficient as a peroxyl radical scavenger, this KP metabolite acts as the chelating agent of Cu(II) ions and is a good protector against the hydroxyl radicals associated with oxidative stress through its secondary antioxidant activity [39].
QA is a well-known neurotoxin produced in the brain [40][62]. It can be a neuroprotective compound but only in low concentration. Increasing QA causes saturation of the catabolic system and this condition becomes toxic [63]. QA exerts neurotoxic effects by several mechanisms including activation of the N-methyl-d-aspartate (NMDA) receptor in pathophysiological concentrations [40]. Elevated levels of QA are noted to be in the case of patients with Alzheimer’s disease and inflammatory disorders. In Huntington’s disease, the increase in the brain QA is accompanied by an increase in cerebral 3Hkyn and a reduction in the brain KYNA [29]. Neurotoxicity of QA is associated with the pathogenesis of neurodegenerative processes connected with neuroinflammation [64]. Therefore, it is associated with such diseases as multiple sclerosis and Huntington’s disease. In vitro experiments demonstrated that QA does not induce the death of lymphocytes [42]. However, in TRP-free extracellular microenvironment, inhibition of T-cell proliferation could be observed [43].
KP by-products—XA and CA—are neuroactive compounds that modulate metabotropic glutamate (mGlu) receptors [23][65][66]. Studies performed on schizophrenia patients have shown a decrease in XA levels in serum compared to healthy controls [67]. This metabolite shows anticonvulsant and antioxidant properties [23]. The formation of XA is believed to be a major detoxification route for 3HKyn production [37]. Notably, CA is a ligand of AhR [65], and shows antibacterial properties [68].
3HAA, AA, and CA are also important players in the shikimic acid pathway [69], allowing the biosynthesis of aromatic amino acids in fungi, bacteria, and plants.
PIC is utilized for the production of local anesthetics or supplements [70], shows antiviral, antifungal, antitumoral properties, and regulates cell growth. In the human body, this compound plays the role of a chelating agent of such elements as zinc, copper, iron, molybdenum, and manganese [71]. It inhibits the proliferation of peripheral blood leukocytes [43].

This entry is adapted from the peer-reviewed paper 10.3390/ijms242216304

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