Langer Mesomelic Dysplasia: History
Please note this is an old version of this entry, which may differ significantly from the current revision.

Langer mesomelic dysplasia is a disorder of bone growth.

  • genetic conditions

1. Introduction

Affected individuals typically have extreme shortening of the long bones in the arms and legs (mesomelia). As a result of the shortened leg bones, people with Langer mesomelic dysplasia have very short stature. A bone in the forearm called the ulna and a bone in the lower leg called the fibula are often underdeveloped or absent, while other bones in the forearm (the radius) and lower leg (the tibia) are unusually short, thick, and curved. Some people with Langer mesomelic dysplasia also have an abnormality of the wrist and forearm bones called Madelung deformity, which may cause pain and limit wrist movement. Additionally, some affected individuals have mild underdevelopment of the lower jaw bone (mandible).

2. Frequency

The prevalence of Langer mesomelic dysplasia is unknown, although the condition appears to be rare. Several dozen affected individuals have been reported in the scientific literature.

3. Causes

Langer mesomelic dysplasia results from changes involving the SHOX gene. The protein produced from this gene plays a role in bone development and is particularly important for the growth and maturation of bones in the arms and legs. The most common cause of Langer mesomelic dysplasia is a deletion of the entire SHOX gene. Other genetic changes that can cause the disorder include mutations in the SHOX gene or deletions of nearby genetic material that normally helps regulate the gene's activity. These changes greatly reduce or eliminate the amount of SHOX protein that is produced. A lack of this protein disrupts normal bone development and growth, which underlies the severe skeletal abnormalities associated with Langer mesomelic dysplasia.

4. Inheritance

Langer mesomelic dysplasia has a pseudoautosomal recessive pattern of inheritance. The SHOX gene is located on both the X and Y chromosomes (sex chromosomes) in an area known as the pseudoautosomal region. Although many genes are unique to either the X or Y chromosome, genes in the pseudoautosomal region are present on both sex chromosomes. As a result, both females (who have two X chromosomes) and males (who have one X and one Y chromosome) normally have two functional copies of the SHOX gene in each cell. The inheritance pattern of Langer mesomelic dysplasia is described as recessive because both copies of the SHOX gene in each cell must be missing or altered to cause the disorder. In females, the condition results when the gene is missing or altered on both copies of the X chromosome; in males, it results when the gene is missing or altered on the X chromosome and the Y chromosome.

A related skeletal disorder called Léri-Weill dyschondrosteosis occurs when one copy of the SHOX gene is mutated in each cell. This disorder has signs and symptoms that are similar to, but typically less severe than, those of Langer mesomelic dysplasia.

5. Other Names for This Condition

  • dyschondrosteosis homozygous

  • Langer mesomelic dwarfism

  • LMD

  • mesomelic dwarfism of the hypoplastic ulna, fibula, and mandible type

This entry is adapted from the peer-reviewed paper


  1. Bertorelli R, Capone L, Ambrosetti F, Garavelli L, Varriale L, Mazza V,Stanghellini I, Percesepe A, Forabosco A. The homozygous deletion of the 3'enhancer of the SHOX gene causes Langer mesomelic dysplasia. Clin Genet. 2007Nov;72(5):490-1.
  2. Campos-Barros A, Benito-Sanz S, Ross JL, Zinn AR, Heath KE. Compoundheterozygosity of SHOX-encompassing and downstream PAR1 deletions results inLanger mesomelic dysplasia (LMD). Am J Med Genet A. 2007 May 1;143A(9):933-8.
  3. Shears DJ, Guillen-Navarro E, Sempere-Miralles M, Domingo-Jimenez R, Scambler PJ, Winter RM. Pseudodominant inheritance of Langer mesomelic dysplasia caused bya SHOX homeobox missense mutation. Am J Med Genet. 2002 Jun 15;110(2):153-7.
  4. Thomas NS, Maloney V, Bass P, Mulik V, Wellesley D, Castle B. SHOX mutationsin a family and a fetus with Langer mesomelic dwarfism. Am J Med Genet A. 2004Jul 15;128A(2):179-84.
  5. Zinn AR, Wei F, Zhang L, Elder FF, Scott CI Jr, Marttila P, Ross JL. Complete SHOX deficiency causes Langer mesomelic dysplasia. Am J Med Genet. 2002 Jun15;110(2):158-63.
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