Advanced Drug Delivery for Treating Sjögren’s Dry Eye: Comparison
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Please note this is a comparison between Version 2 by Kevin Yang Wu and Version 1 by Kevin Yang Wu.

Sjögren’s syndrome is a chronic and insidious autoimmune disease characterized by lymphocyte infiltration of exocrine glands. Patients typically present with dry eye (keratoconjunctivitis sicca), dry mouth (xerostomia), and other systemic manifestations. The current management for Sjögren's syndrome dry eye (SSDE) has been ineffective as it only targets ocular surface inflammation and dryness without addressing the specific disease process. Ophthalmologists often adopt a trial-and-error approach, which allows the cycle of dry eye disease (DED) to progress and potentially cause permanent damage to the lacrimal functional unit. Topical treatments also depend on patients' ability to administer eye drops and their compliance. These limitations emphasize the need for personalized, targeted treatments that address the underlying pathophysiology of SSDE. This article aims to present new advances in ocular drug delivery for more effective treatment.

 

 

  • sjögren syndrome
  • dry eye
  • ocular drug delivery
  • topical administration
  • nanocarriers
  • subconjunctival
  • episcleral and intravitreal implant
  • controlled release systems
  • basic research
  • pathophysiology
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