CMR Findings of Myocardial Inflammation and Pathological Correlations: Comparison
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Myocarditis comprises many clinical presentations ranging from asymptomatic to sudden cardiac death. The history, physical examination, cardiac biomarkers, inflammatory markers, and electrocardiogram are usually helpful in the initial assessment of suspected acute myocarditis. Echocardiography is the primary tool to detect ventricular wall motion abnormalities, pericardial effusion, valvular regurgitation, and impaired function. The advancement of cardiac magnetic resonance (CMR) imaging has been helpful in clinical practice for diagnosing myocarditis. The present review highlights the unmet clinical needs for uniform CMR criteria for diagnosing acute and chronic myocarditis in children and differentiating dilated chronic myocarditis phenotype from idiopathic dilated cardiomyopathy. 

  • myocarditis
  • children

1. Introduction

Myocarditis is an inflammatory disease of the myocardium and is a rare diagnosis in children accounting for only 0.05% of pediatric hospital admissions [1]. Acute myocarditis has a heterogeneous clinical course ranging from the asymptomatic presentation and gradual onset of heart failure to fulminant myocarditis presenting as cardiogenic shock and sudden death [2][3]. The complexity of these divergent presentations is further compounded by the continuously evolving diagnostic criteria, making the diagnosis exceptionally challenging [2]. Children with acute myocarditis often present with resting tachycardia, chest pain, respiratory distress, abdominal pain, and vomiting [3][4][5][6]. Chest pain is a typical symptom of acute myocarditis in adolescents [7]. Electrocardiography (ECG) abnormalities are present in approximately 90% of children with myocarditis, including ST-T wave, changes, low voltage QRS complexes, and atrioventricular conduction delays [3][5][6]. Elevations in cardiac biomarkers such as troponin and brain-type natriuretic peptides are common but not specific for acute myocarditis in children [3][7][8].
Echocardiography is the primary tool to determine the presence of left ventricular (LV) wall motion abnormalities, pericardial effusion, valvular abnormalities, and function assessment [9]. Endomyocardial biopsy (EMB) is the “gold standard” to confirm myocarditis, but it is an invasive procedure with suboptimal sensitivity. The advancement of cardiac magnetic resonance (CMR) imaging has been helpful in clinical practice for diagnosing myocarditis. Reflecting this evolution, a recent Scientific Statement by the American Heart Association (AHA) suggested CMR as the current gold standard for diagnosing myocarditis [10]. In addition to tissue characterization, CMR is useful for evaluating the ventricular function, myocardial wall thickness, chamber dilation, and pericardial effusion.
Clinically acute myocarditis implies a short time elapsed from the onset of symptoms (generally <1 month and up to 8 weeks) [11][12]. Chronic myocarditis (course of disease ≥ 3 months) is a type of inflammatory cardiomyopathy with either a dilated or non-dilated phenotype that is often characterized by regional or global wall motion abnormalities and impaired LV function [10]. In general, the prognosis of acute myocarditis is good, but up to 30% of cases may progress to develop a dilated cardiomyopathy phenotype [13]. The relative roles of viruses, host genomics, and environmental factors in disease progression and recovery are still unknown [14]. Consequently, treatment strategies are not well established. Confirming the diagnosis of acute myocarditis in children by CMR with tissue characterization using inverse recovery acquisition findings of myocardial inflammation is an essential milestone in the right direction and a paradigm shift towards a decreased need for EMB [10]. However, standard CMR parametric mapping parameters for diagnosing myocarditis are not established in pediatric patients for consistency and reliability in the interpretation. 

2. CMR Findings of Myocardial Inflammation and Pathological Correlations

Tissue characterization by CMR parametric mapping allows quantifying myocardial changes based on T1 and T2 images for fibrosis, water content, and extracellular volume fractions (ECV), a surrogate of interstitial fibrosis (Figure 1A–C and Figure 2A–C). It enables differentiation between normal myocardial muscle, edema, and fibrosis, thereby serving as a virtual biopsy [14][15]. CMR allows evaluation of all myocardial segments, contributing to its superior sensitivity to EMB to detect myocarditis because myocardial inflammation often has a heterogeneous, “patchy” distribution. Late gadolinium enhancement (LGE) helps detect scarring and necrosis.
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Figure 1. T1 mapping demonstrates a global increase in myocardial T1 relaxation times at the base (A), mid-ventricular level (B), and the apex (C). The average left ventricular myocardial T1 relaxation time is prolonged (1067 ms), and myocardial extracellular volume is elevated (32%).
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Figure 2. T2 mapping demonstrating the regional increase in myocardial T2 relaxation times at the basal anteroseptal and anterolateral segments (A), with normal T2 times at the mid-ventricular level (B) and the apex (C). Clinical vignette: A 20-month-old female with myocarditis associated with rhino/enterovirus, rapid left ventricular ejection fraction recovery from 24% to 48%, elevated troponin, and diffuse low voltage QRS complexes on electrocardiogram. There was no evidence of myocardial delayed enhancement after gadolinium contrast emphasizing the additional utility of T1 and T2 mapping in the evaluation of myocarditis.
The diagnostic CMR criteria are derived from the common consensus among experts (Lake Louise Consensus (LLC) criteria) for myocarditis in adults [16]. The hallmark features of myocardial inflammation on CMR are (1) T2-weighted imaging, which assesses for edema; (2) T1-weighted early gadolinium enhancement imaging (EGE), which assesses for hyperemia; and (3) LGE, which assesses for myocyte necrosis and scar. The CMR LLC criteria seem to have moderate accuracy in diagnosing acute myocarditis [17][18]. LLC criteria are qualitative analyses and rely upon the increased signal intensity of the myocardium relative to the normal myocardium. These criteria, therefore, have limited applicability for diffuse myocardial involvement without focal findings. Subsequently, a revised version of the LLC was released in 2018 with quantitative tissue mapping techniques. According to the updated LLC criteria, myocarditis can be diagnosed with high specificity based on: (i) the presence of one of the T2-based criteria (i.e., regional or global increase in T2 relaxation time or increased signal intensity on T2 weighted images) and (ii) the presence of one T1-based criterion out of three: prolonged T1 relaxation time, elevated ECV or LGE [19]. Both criteria have a reported median area under the curve for detecting myocarditis ranging from 0.75 to 0.90. Either isolated T1- or T2-based criteria in the appropriate clinical setting can suggest myocardial inflammation in adults [19][20]. It is important to note that the LLC criteria have not been validated in children.
The parametric mapping techniques have only recently begun to enter clinical use in children, and their predictive utility in acute myocarditis remains an active area of investigation. There is no comprehensive data for CMR based on the revised LLC criteria in pediatric myocarditis except for small observational studies. A study on 43 consecutive clinically suspected pediatric acute myocarditis patients demonstrated that the revised LLC criteria enhance the diagnostic performance compared to conventional LLC criteria [21]. In another retrospective study in 58 children with acute clinical myocarditis, LGE was identified as a predictor of poor outcomes [22]. Conventional LGE imaging can underestimate the amount of myocardial injury in myocarditis. Native T1 and ECV maps may reveal hidden myocardial injury in the normal-appearing myocardium of patients with myocarditis.
In one study, CMR was reported to have a low yield in diagnosing the severity of acute myocarditis and does not predict outcomes in children [23]. However, their study was likely underpowered to detect the outcome. Due to variability between individual scanners and local site references, there are significant differences in CMR tissue characterization techniques among pediatric centers and no standardized cutoff values for T1 or T2 relaxation times. Most centers use LGE for diagnosing scar or myocardial necrosis [24]. The presence of LGE is likely a robust prognostic marker in children and adults with myocarditis [25][26].
Subepicardial inferolateral LGE is the most common pattern in adult patients with acute myocarditis [27]. In contrast, a higher prevalence of a mid-wall or mixed LGE pattern is reported in pediatric patients [27]. The mid-wall or mixed pattern of LGE was associated with more severe disease progression and a higher complication rate than the subepicardial inferolateral pattern [28][29]. The LGE distribution pattern may help differentiate myocarditis from ischemic myocardial injury as seen in the anomalous left coronary artery from the pulmonary artery (ALCAPA), congenital coronary ostial stenosis or atresia, coronary fistula, or Kawasaki disease (KD) [30][31]. LGE involves the subendocardium following a coronary territory in cases of ALCAPA, and KD confers to an infarction-like pattern. In more severe cases, LGE may extend to transmural, resulting in a fully transmural pattern (Figure 3).
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Figure 3. Late gadolinium enhancement (LGE) imaging allows the noninvasive visualization of areas affected by myocardial scar, conferring clinicians the unique ability to differentiate ischemic from nonischemic lesions based on typical LGE patterns.
LGE patterns for viral myocarditis are often confined to the intramural septal wall or subepicardial lateral wall (Figure 4A,B), but the presence of LGE alone does not inform the chronicity of the disease process. Furthermore, Mahrholdt et al. [32] described different LGE patterns and correlated them with viral etiologies of acute myocarditis in children and young adults. Parvovirus B19 myocarditis had LGE in the inferolateral segments. In contrast, human herpes simplex type 6 (HHV6) myocarditis had LGE in the intraventricular septum, and the difference in distribution was due to different viral cardiac tropisms. A summary of CMR findings in children with either clinically suspected or EMB proved acute and chronic myocarditis in children are described in Table 1.
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Figure 4. CMR in an adolescent with acute myocarditis: (A) Shows subepicardial early gadolinium enhancement (EGE) (white arrow); (B) Shows subepicardial LGE (white arrow).
Table 1. CMR findings in clinically suspected acute and chronic myocarditis in children.
Reference n Age CMR in Days Following Acute Clinical Myocarditis Abnormal T1 Plus T2 CMR Findings n (%) LGE +

n (%)
Gagliardi et al. [33] 11 9 mo–

9 yrs		 24–48 days Tissue characterization obtained in T1 weighed spin-echo sequences in 100% of pts  
Banka et al. [24] 143 16 yrs

(mean)		 2 days

(mean)		 LLC + ve in 117 (82%), negative in 18 (13%),

And equivocal in 7 (5%)

yielding a sensitivity of 82%		 115 (81%)
Martinez-Villar et al. [7] 26 0–16 yrs

(median) 14 yrs		 11–53 days Total of 2 of 3 LLC in all 26 patients (100%) 26 (100%)
Cornicelli et al. [22] 23 15.1 yrs

(mean)		 4.5 days

(mean)		 LLC: diagnostic yield 57%

Revised LLC increased diagnostic yield to77%		 86%
Chinali et al. [25] 40 2–17 yrs

(median)

13 yrs		 At admission

10/40 had FU CMR		 Myocardial edema in 33 (82.5%)

6 recovered, 4(40%) had persistent fibrosis		 19 (47.5%)

4(40%) had persistent LGE
Dubey et al. [34] 34

(Follow-up CMR in 12 who had LGE at baseline)		 10–17 yrs

(median 16 yrs)		 After discharge   Persistence LGE in 10/12 (83%)
Martin et al. [28] 125 Average 15.1 yrs Average 8 days Revised LLC in 94 (76%)

79 had FU: 16 pts had disappearance of LLC		 93 (74.4%)

35(28%) had persistent LGE
Isaak et al. [21] 43

(Follow-up CMR in 27/43 pts

But only 17 had parametric mapping available)		 8–21 yrs

(mean) 17 yrs		 1–9 days of initial diagnosis

53 days from the initial CMR

(median)		 Focal edema in 32 (74.4%)

Persistent focal edema in 12/27 (44.4%)		 36 (83.7%)

LGE persistent in 20/27 (74%)
Patients with DCM often have a linear mid-myocardial LGE pattern, but a subendocardial pattern strongly suggests previous myocardial ischemia or necrosis due to microthrombus but spontaneous coronary recanalization or distal embolization from minimally stenotic coronary lesions [35]. In contrast, chronic myocarditis rarely presents with a subendocardial LGE pattern and rarely follows coronary artery distribution. Instead, the hallmark LGE pattern of chronic myocarditis consists of patchy or longitudinal striae of mid-wall and subepicardial enhancement. In chronic myocarditis, parametric tissue mapping to evaluate myocardial T1 relaxation time and ECV helps detect diffuse fibrosis without focal LGE [36].

It is important to differentiate between inflammatory cardiomyopathy (subacute/chronic myocarditis with abnormal ventricular function) from idiopathic dilated cardiomyopathy as there is a significant difference in prognosis and outcomes between the two. In chronic myocarditis, the sensitivity of CMR drops significantly as edema becomes progressively less prominent than in acute myocarditis and even disappears entirely in up to 84% of cases. Furthermore, long-term studies are necessary to determine whether CMR can assist in predicting long-term outcomes.

References

  1. Klugman, D.; Berger, J.T.; Sable, C.A.; He, J.; Khandelwal, S.G.; Slonim, A.D. Pediatric patients hospitalized with myocarditis: A multi-institutional analysis. Pediatric Cardiol. 2010, 31, 222–228.
  2. Ghelani Sunil, J.; Spaeder Michael, C.; Pastor, W.; Spurney Christopher, F.; Klugman, D. Demographics, Trends, and Outcomes in Pediatric Acute Myocarditis in the United States, 2006 to 2011. Circ. Cardiovasc. Qual. Outcomes 2012, 5, 622–627.
  3. Rodriguez-Gonzalez, M.; Sanchez-Codez, M.I.; Lubian-Gutierrez, M.; Castellano-Martinez, A. Clinical presentation and early predictors for poor outcomes in pediatric myocarditis: A retrospective study. World J. Clin. Cases 2019, 7, 548–561.
  4. Canter, C.E.; Simpson, K.E. Diagnosis and treatment of myocarditis in children in the current era. Circulation 2014, 129, 115–128.
  5. Dasgupta, S.; Iannucci, G.; Mao, C.; Clabby, M.; Oster, M.E. Myocarditis in the pediatric population: A review. Cong Heart Dis. 2019, 14, 868–877.
  6. Bejiqi, R.; Retkoceri, R.; Maloku, A.; Mustafa, A.; Bejiqi, H.; Bejiqi, R. The diagnostic and clinical approach to pediatric myocarditis: A review of the current literature. Open Access Maced. J. Med. Sci. 2019, 7, 162–173.
  7. Martinez-Villar, M.; Gran, F.; Sabaté-Rotés, A.; Tello-Montoliu, A.; Castellote, A.; Figueras-Coll, M.; Ferrer, Q.; Roses-Noguer, F. Acute myocarditis with infarct-like presentation in a pediatric population: Role of cardiovascular magnetic resonance. Pediatric Cardiol. 2018, 39, 51–56.
  8. Abrar, S.; Ansari, M.J.; Mittal, M.; Kushwaha, K.P. Predictors of mortality in pediatric myocarditis. J. Clin. Diagn. Res. 2016, 10, Sc12–Sc16.
  9. Kociol, R.D.; Cooper, L.T.; Fang, J.C. recognition and initial management of fulminant myocarditis: A scientific statement from the American Heart Association. Circulation 2020, 141, e69–e92.
  10. Law, Y.M.; Lal, A.K.; Chen, S.; Cihakova, D.; Cooper, L.T.; Deshpande, S.; Godown, J.; Grosse-Wortmann, L.; Robinson, J.D.; Towbin, J.A.; et al. American Heart Association Pediatric Heart Failure and Transplantation Committee of the Council on Lifelong Congenital Heart Disease and Heart Health in the Young and Stroke Council. Diagnosis and management of myocarditis in children: A scientific statement from the American Heart Association. Circulation 2021, 144, e123–e135.
  11. Ammirati, E.; Frigerio, M.; Adler, E.; Basso, C.; Birnie, D.H.; Brambatti, M.; Hare, J.M.; Heidecker, B.; Heymans, S.; Hubner, N.; et al. Management of acute myocarditis and chronic inflammatory cardiomyopathy: An expert consensus document. Circ. Heart Fail. 2020, 13, e007405.
  12. McNamara, D.M.; Starling, R.C.; Cooper, L.T.; Boehmer, J.P.; Mather, P.J.; Janosko, K.M.; Gorscan, J., 3rd; Kip, K.E.; Dec, G.W. Clinical and demographic predictors of outcomes in recent-onset dilated cardiomyopathy. Results of the IMAC (Intervention in Myocarditis and Acute Cardiomyopathy)-2 study. J. Am. Coll. Cardiol. 2011, 58, 1112–1118.
  13. Caforio, A.L.P.; Pankuweit, S.; Arbustini, E.; Basso, C.; Gimeno-Blanes, J.; Felix, S.B.; Fu, M.; Heliö, T.; Heymans, S.; Jahns, R.; et al. Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: A position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur. Heart J. 2013, 34, 2636–4814.
  14. Tschope, C.; Ammirati, E.; Bozkurt, B.; Caforio, A.L.P.; Cooper, L.T.; Felix, S.B.; Hare, J.M.; Heidecker, B.; Heymans, S.; Hübner, N.; et al. Myocarditis and inflammatory cardiomyopathy: Current evidence and future directions. Nat. Rev. Cardiol. 2021, 18, 169–193.
  15. Klein, A.L.; Abbara, S.; Agler, D.A.; Appleton, C.P.; Asher, C.R.; Hoit, B.; Hung, J.; Garcia, M.J.; Kronzon, I.; Oh, J.K.; et al. American Society of Echocardiography clinical recommendations for multimodality cardiovascular imaging of patients with pericardial disease. J. Am. Soc. Echocardiogr. 2013, 26, 965–1012.
  16. Friedrich, M.G.; Sechtem, U.; Schulz-Menger, J.; Holmvang, G.; Alakija, P.; Cooper, L.T.; Liu, P.; White, J.A.; Abdel-Aty, H.; Gutberlet, M.; et al. Cardiovascular magnetic resonance in myocarditis: A JACC white paper. J. Am. Coll. Cardiol. 2009, 53, 1475–1487.
  17. Wei, S.; Fu, J.; Chen, L.; Yu, S. Performance of cardiac magnetic resonance imaging for diagnosis of myocarditis compared with endomyocardial biopsy. Med. Sci. Monit. 2017, 23, 3687–3696.
  18. Pan, J.A.; Lee, Y.J.; Salerno, M. Diagnostic performance of extracellular volume, native T1, and T2 mapping versus lake Louis criteria by cardiac magnetic resonance for detection of acute myocarditis: A meta-analysis. Circ. Cardiovasc. Imaging 2018, 11, e007598.
  19. Ferreira, V.M.; Schulz-Menger, J.; Holmvang, G.; Kramer, C.M.; Carbone, I.; Sechtem, U.; Kinderman, I.; Gutberlet, M.; Cooper, L.T.; Liu, P.; et al. Cardiovascular magnetic resonance in nonischemic myocardial inflammation: Expert recommendations. J. Am. Coll. Cardiol. 2018, 72, 3158–3176.
  20. Luetkens, J.A.; Faron, A.; Isaak, A.; Kuetting, D.; Gliem, C.; Dabir, D.; Kornblum, C.; Thomas, D. Comparison of original and 2018 Lake Louise criteria for diagnosis of acute myocarditis: Results of a validation cohort. Radiol. Cardiothorac. Imaging 2019, 1, e190010.
  21. Isaak, A.; Bischoff, L.; Faron, A.; Endler, C.; Mesropyan, N.; Sprinkart, A.; Peiper, C.C.; Kuetting, D.; Dabir, D.; Attenberger, U.; et al. Multiparametric cardiac magnetic resonance imaging in pediatric and adolescent patients with acute myocarditis. Pediatric Radiol. 2021, 51, 2470–2480.
  22. Cornicelli, M.D.; Rigsby, C.K.; Rychlik, K.; Pahl, E.; Robinson, J.D. Diagnostic performance of cardiovascular magnetic resonance native T1 and T2 mapping in pediatric patients with acute myocarditis. J. Cardiovasc. Magn. Reson. 2019, 21, 40.
  23. Hales-Kharazmi, A.; Hirsch, N.; Slesnik, T.; Deshpande, S.R. Utility of cardiac MRI in pediatric myocarditis. Cardiol. Young 2018, 3, 377–385.
  24. Banka, P.; Robinson, J.D.; Uppu, S.C.; Harris, M.A.; Hasbani, K.; Lai, W.W.; Richmond, M.; Fratzz, S.; Jain, S.; Johnson, T.R.; et al. Cardiovascular magnetic resonance techniques and findings in children with myocarditis: A multicenter retrospective study. J. Cardiovasc. Magn. Reson. 2015, 17, 96.
  25. Chinali, M.; Franceschini, A.; Ciancarella, P.; Lisignoli, V.; Curione, D.; Ciliberti, P.; Esposito, C.; Pasqua, A.D.; Rinelli, G.; Secinaro, A. Echocardiographic two-dimensional speckle tracking identifies acute regional myocardial edema and sub-acute fibrosis in pediatric focal myocarditis with normal ejection fraction: Comparison with cardiac magnetic resonance. Sci. Rep. 2020, 10, 11321.
  26. Francone, M.; Chimenti, C.; Galea, N.; Scopelliti, F.; Verardo, R.; Galea, R.; Carbone, I.; Catalano, C.; Fedele, F.; Frustaci, A. CMR sensitivity varies with clinical presentation and extent of cell necrosis in biopsy-proven acute myocarditis. JACC Cardiovasc. Imaging 2014, 7, 254–263.
  27. Yuan, W.-F.; Zhao, X.-X.; Sun, W.-J.; Shao-Ping, W.; Ya-Bin, L.; Tang, X. LGE-MRI in the assessment of left ventricular remodeling in myocarditis. Curr. Med. Imaging 2019, 15, 900–905.
  28. Martins, D.S.; Ait-Ali, L.; Khraiche, D.; Festa, P.; Barison, A.; Martini, N.; Benadjaoud, Y.; Anjos, R.; Boddaert, N.; Bonnet, D.; et al. Evolution of acute myocarditis in a pediatric population: An MRI based study. Int. J. Cardiol. 2021, 329, 226–233.
  29. Grigoratus, C.; Bella, G.D.; Aquaro, G.D. Diagnostic and prognostic role of cardiac magnetic resonance in acute myocarditis. Heart Fail. Rev. 2019, 24, 81–90.
  30. Dusenbery, S.M.; Newburger, J.W.; Colan, S.D.; Gauvreau, K.; Baker, A.; Powell, A.J. Myocardial fibrosis in patients with a history of Kawasaki disease. IJC Heart Vasc. 2021, 32, 100713.
  31. Secinaro, A.; Ntsinjana, H.; Tann, O.; Schuler, P.K.; Muthurangu, V.; Hughes, M.; Tsang, V.; Taylor, A.M. Cardiovascular magnetic resonance findings in repaired anomalous left coronary artery to pulmonary artery connection (ALCAPA). J. Cardiovasc. Magn. Reson. 2011, 1391, 27.
  32. Mahrholdt, H.; Wagner, A.; Deluigi, C.C.; Kispert, E.; Hager, S.; Meinhardt, G.; Vogelseberg, H.; Fritz, P.; Dippon, J.; C-Thomas, B.; et al. Presentation, patterns of myocardial damage, and clinical course of viral myocarditis. Circulation 2006, 114, 1581–1590.
  33. Gagliardi, M.G.; Bevilacqua, M.; Di Renzi, P.; Picardo, S.; Passariello, R.; Marcelletti, C. Usefulness of magnetic resonance imaging for diagnosis of acute myocarditis in infants and children, and comparison with endomyocardial biopsy. Am. J. Cardiol. 1991, 68, 1089–1091.
  34. Dubey, S.; Agarwal, A.; Nguyen, S.; Adebo, D. Persistence of late gadolinium enhancement on follow-up CMR imaging in children with acute myocarditis. Pediatric Cardiol. 2020, 41, 1777–1782.
  35. Saeed, M.; Hetts, S.W.; Jablonowski, R.; Wilson, M.W. Magnetic resonance imaging and multi-detector computed tomography assessment of extracellular compartment in ischemic and nonischemic myocardial pathologies. World J. Cardiol. 2014, 6, 1192–1218.
  36. Messroghli, D.R.; Moon, J.C.; Ferreira, V.M.; Grosse-Wortmann, L.; He, T.; Kellman, P. Clinical recommendations for cardiovascular magnetic resonance mapping of T1, T2, T2* and extracellular volume: A consensus statement by the Society for Cardiovascular Magnetic Resonance (SCMR) endorsed by the European Association for Cardiovascular Imaging (EACVI). J. Cardiovasc. Magn. Reson. 2017, 19, 75.
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