Plant-based foods, such as fruits, contain natural active principles, ranging from primary metabolites (nutritive factors, vitamins, and minerals) to secondary metabolites (phytochemicals). These bioactive principles play significant roles in mitigating several chronic diseases. Some epidemiological studies have identified antioxidant-rich secondary metabolites, such as flavonoids and anthocyanin, for their anti-inflammatory, antiproliferative, and ameliorative roles in neurological disorders. Generally, natural polyphenols express their neuroprotective capacity by relying on their mechanism ability to cross the blood-brain barrier to scavenge the pathological concentrations of reactive oxygen and nitrogen species. Equally, polyphenols modulate a series of mediating cell-signaling pathways of pathological diseases.