IMany authors have recognized that a variety of barriers can hinder the implementation of industrial symbiosis (IS) can contribute to achieving a win-win situation between industry and environment for local and regionaland eco-industrial development. It is imperative to prioritize the barriers which will provide guidance for the realization of IS projects and assist practitioners and stakeholders with more effective implementation. This, in turn, will contribute to development of circular economies. Industrial symbiosis (IS) has been well-recognized as a key subfield of industrial ecology (IE). A widely cited definition of IS is presented by Chertow:“engaging traditionally separate entitiesThrough an extensive literature review, this paper proposes a model which combines the Analytic Hierarchy Process (AHP) and the Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) to evaluate the IS barriers semi-quantitatively. This model assists in identifying and prioritizing the fundamental barriers for implementation of IS in a collective approach to competitive advantage involving physical exchange of materials, energy, watermprehensive manner. An operating IS, the Hai Hua Group (HHG), in Shandong Province, China is used as a case study to test the proposed model. The results show that the top four generic barriers are technological, economic, safety, and by-products. The keys to IS are collaboration and the synergistic possibilities offered by geographic proximity” (p. 314)informational barriers. More specifically, the barriers are information platforms, human safety and health, technology involved with extending industrial chains, product added value, and costs. The paper concludes by discussing managerial implications for promoting the establishment and operation of IS.